公开(公告)号：US20160376344A1

公开(公告)日：2016-12-29

申请号：US15163561

申请日：2016-05-24

Applicant: Amunix Operating Inc.

Inventor： Volker SCHELLENBERGER ,  Pei-Yun CHANG ,  Fatbardha VARFAJ ,  John KULMAN ,  Tongyao LIU ,  Garabet G. TOBY ,  Haiyan JIANG ,  Robert PETERS ,  Deping WANG ,  Baisong MEI ,  Joshua SILVERMAN ,  Chia-Wei WANG ,  Benjamin SPINK ,  Nathan GEETHING

IPC: C07K14/755 ,  C07K14/00

CPC classification number: C07K14/755 ,  A61K38/00 ,  C07K14/001 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/31 ,  C07K2319/41 ,  C07K2319/50 ,  C07K2319/95

Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.

公开(公告)号：US20160199454A1

公开(公告)日：2016-07-14

申请号：US14912047

申请日：2014-08-14

Applicant: BIOGEN MA INC. ,  AMUNIX OPERATING INC.

Inventor： Tongyao LIU ,  Pei-Yun CHANG ,  John KULMAN ,  Volker SCHELLENBERGER ,  Haiyan JIANG ,  Robert T. PETERS ,  Ekta Seth CHHABRA

IPC: A61K38/37 ,  A61K9/00 ,  C07K14/00 ,  C07K14/755

Abstract: The present invention provides chimeric proteins comprising a Factor VIII (FVIII) polypeptide and XTEN polypeptides. The FVIII polypeptide can have a reduced affinity for von Willebrand Factor (VWF). XTEN polypeptides of appropriate sizes are inserted into the FVIII polypeptide at particular locations in order to extend the half-life of the FVIII polypeptide. The invention also includes nucleotides, vectors, host cells, and methods of using the chimeric proteins, e.g., to treat bleeding diseases and disorders.

Abstract translation: 本发明提供了包含因子VIII（FVIII）多肽和XTEN多肽的嵌合蛋白。 FVIII多肽可以对血管性血友病因子（VWF）具有降低的亲和力。 适当大小的XTEN多肽在特定位置插入FVIII多肽中，以延长FVIII多肽的半衰期。 本发明还包括核苷酸，载体，宿主细胞和使用嵌合蛋白的方法，例如治疗出血疾病和病症。