公开(公告)号：US20210102939A1

公开(公告)日：2021-04-08

申请号：US16594843

申请日：2019-10-07

Applicant: Biogen MA Inc.

Inventor： Leonid GORELIK ,  Kenneth J. SIMON ,  Meena SUBRAMANYAM ,  Mia Marie RUSHE

IPC: G01N33/543

Abstract: The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.

公开(公告)号：US20250003983A1

公开(公告)日：2025-01-02

申请号：US18731059

申请日：2024-05-31

Applicant: BIOGEN MA INC.

Inventor： Gary Lewis BLOOMGREN ,  Carmen BOZIC ,  Sophia LEE ,  Amy PACE ,  Tatiana PLAVINA ,  Meena SUBRAMANYAM

IPC: G01N33/68 ,  C07K16/28 ,  C12N7/00 ,  C12Q1/70 ,  G01N33/569

Abstract: The invention relates to methods of assessing a patient' s risk of developing Progressive multifocal leukoencephalopathy (PML).

公开(公告)号：US20220397571A1

公开(公告)日：2022-12-15

申请号：US17705092

申请日：2022-03-25

Applicant: Biogen MA Inc.

Inventor： Leonid GORELIK ,  Kenneth J. SIMON ,  Meena SUBRAMANYAM ,  Mia Marie RUSHE

IPC: G01N33/543

Abstract: The invention relates to methods and reagents for analyzing samples for the presence of JC virus antibodies.

公开(公告)号：US20220357339A1

公开(公告)日：2022-11-10

申请号：US17700250

申请日：2022-03-21

Applicant: BIOGEN MA INC.

Inventor： Gary Lewis BLOOMGREN ,  Carmen BOZIC ,  Sophia LEE ,  Amy PACE ,  Tatiana PLAVINA ,  Meena SUBRAMANYAM

IPC: G01N33/68 ,  G01N33/569 ,  C12N7/00 ,  C07K16/28

Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).

公开(公告)号：US20190137511A1

公开(公告)日：2019-05-09

申请号：US16115350

申请日：2018-08-28

Applicant: BIOGEN MA INC.

Inventor： Gary Lewis BLOOMGREN ,  Carmen BOZIC ,  Sophia LEE ,  Amy PACE ,  Tatiana PLAVINA ,  Meena SUBRAMANYAM

IPC: G01N33/68 ,  C07K16/28 ,  G01N33/569 ,  C12N7/00

CPC classification number: G01N33/6854 ,  C07K16/2842 ,  C07K2317/24 ,  C12N7/00 ,  C12N2710/22011 ,  C12Q1/70 ,  G01N33/56983 ,  G01N2333/025 ,  G01N2469/20 ,  G01N2800/24 ,  G01N2800/28 ,  G01N2800/50

Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).