公开(公告)号：US20250000414A1

公开(公告)日：2025-01-02

申请号：US18755391

申请日：2024-06-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Wei GAO ,  Changhao XU

IPC: A61B5/16 ,  A61B5/00 ,  A61B5/145

Abstract: Systems and methods for a wearable stress response assessment system may include an iontophoresis module, a multi-inlet microfluidic sweat sampling component, and a sensor patch configured to detect concentrations of electrolytes and metabolites present in a sweat sample and monitor physiological signs prevalent in a human patient. An iontophoresis module may provide for stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may be achieved via electrostimulation and/or application of a stimulating agent. A microfluidic sweat sampling component may include adhesive and PDMS layers with carefully designed inlets and channels for efficient collection and sampling of biofluid. Enzymatic and ISE biosensors may quickly and accurately identify concentrations of key biomarkers present in a biofluid sample which may assess, in combination with monitored physiological signs, a human patient's stress response.