公开(公告)号：US20240023880A1

公开(公告)日：2024-01-25

申请号：US18225403

申请日：2023-07-24

Applicant: California Institute of Technology

Inventor： Wei GAO ,  Jiaobing TU

IPC: A61B5/00 ,  A61B5/145

CPC classification number: A61B5/4266 ,  A61B5/14521 ,  A61B5/14539 ,  A61B5/14546

Abstract: Some implementations of the disclosure relate to a wearable biosensor device including an iontophoresis module configured to stimulate production of a sweat sample from skin of a user, the sweat sample including biomarkers; a microfluidic module configured to collect the sweat sample, mix the sweat sample with labeled detection reagents to obtain a mixture including the biomarkers bound to the labeled detection reagents, and route the mixture to a detection reservoir of the microfluidic module; and a sensor assembly including a bioaffinity sensor configured to quantify the biomarkers of the mixture in the detection reservoir to determine a concentration of the biomarkers present in the sweat sample. The bioaffinity sensor includes an electrode functionalized to bind to the biomarkers of the mixture. The bioaffinity sensor can quantify the biomarkers to determine their concentration with a sensitivity on the order nanomoles or picomoles.

公开(公告)号：US20240366117A1

公开(公告)日：2024-11-07

申请号：US18776522

申请日：2024-07-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Wei GAO ,  Yu SONG

IPC: A61B5/145 ,  A61B5/00 ,  H02N1/04

Abstract: Systems and methods for a self-powered wireless wearable sensor system include a freestanding triboelectric nanogenerator (FTENG), used as a power source for a wearable sensor. The FTENG includes stator panels and corresponding slider panels with a grating pattern. Movement, such as cardiovascular exercise causes the slider panel(s) to slide across the stator panel(s) inducing a charge and powering a wearable device sufficiently to support data transmission and continuous monitoring. An integrated self-powered wireless wearable sensor system includes a microfluidic sweat sensor patch which may be connected to lower-power wireless sensor circuitry for regulating power efficiently and is powered by the FTENG.

公开(公告)号：US20240325001A1

公开(公告)日：2024-10-03

申请号：US18605727

申请日：2024-03-14

Applicant: California Institute of Technology

Inventor： Wei GAO ,  Cui YE

IPC: A61B10/00 ,  A61B90/00

CPC classification number: A61B10/0064 ,  A61B90/39

Abstract: Some implementations of the disclosure relate to a wearable biosensor device including: a microfluidic module configured to collect a sweat sample from skin of a user, route the sweat sample to a sensing reservoir that is filled with the sweat sample, and route additional sweat away from the sensing reservoir when the sensing reservoir is filled; and a sensor assembly configured to quantify the biomarker of the sweat sample in the sensing reservoir to determine a concentration of the biomarker present in the sweat sample. The sensor assembly includes a biorecognition interface having a surface functionalized with an aptamer that binds to the biomarker.

公开(公告)号：US20250068241A1

公开(公告)日：2025-02-27

申请号：US18815534

申请日：2024-08-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Wei GAO ,  Yu SONG ,  Roland Yingjie TAY

IPC: G06F3/01 ,  B29C48/00 ,  B33Y80/00 ,  G06F1/16

Abstract: Systems and methods for a wearable system that monitors various biomarkers with a 3D-printed wearable electronic skin. Specifically, the wearable system is a 3D-printed epidermal wearable microfluidic electronic skin that may be composed of a combination of multidimensional nanomaterials, polymers, and hydrogels. The epidermal wearable microfluidic electronic skin may be integrated with sensors, electrodes, microfluidics, and a processor to collect and analyze molecular biomarkers of biofluid samples on the user's skin, while simultaneously analyzing the user's physiological biomarkers to conduct a health status assessment or gather health monitoring/surveillance metric.

公开(公告)号：US20250000414A1

公开(公告)日：2025-01-02

申请号：US18755391

申请日：2024-06-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Wei GAO ,  Changhao XU

IPC: A61B5/16 ,  A61B5/00 ,  A61B5/145

Abstract: Systems and methods for a wearable stress response assessment system may include an iontophoresis module, a multi-inlet microfluidic sweat sampling component, and a sensor patch configured to detect concentrations of electrolytes and metabolites present in a sweat sample and monitor physiological signs prevalent in a human patient. An iontophoresis module may provide for stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may be achieved via electrostimulation and/or application of a stimulating agent. A microfluidic sweat sampling component may include adhesive and PDMS layers with carefully designed inlets and channels for efficient collection and sampling of biofluid. Enzymatic and ISE biosensors may quickly and accurately identify concentrations of key biomarkers present in a biofluid sample which may assess, in combination with monitored physiological signs, a human patient's stress response.

公开(公告)号：US20240358328A1

公开(公告)日：2024-10-31

申请号：US18662992

申请日：2024-05-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Wei GAO ,  You YU

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B10/00 ,  H01M8/16

CPC classification number: A61B5/6832 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14517 ,  A61B5/1486 ,  H01M8/16 ,  A61B10/0051 ,  A61B10/0064 ,  A61B2010/0067 ,  A61B10/007 ,  A61B2560/0214

Abstract: An auto-powered biosensor capable detecting a target molecule, and a method of powering the same, wherein the biosensor is fabricated with a microfluidics layer, a multimodal sensing layer comprising a biofuel cell and an electrode, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon.

公开(公告)号：US20240277889A1

公开(公告)日：2024-08-22

申请号：US18444514

申请日：2024-02-16

Applicant: California Institute of Technology

Inventor： Wei GAO ,  Elham DAVOODI

IPC: A61L24/00 ,  A61K9/127 ,  A61M37/00 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/00 ,  B33Y70/00

CPC classification number: A61L24/0015 ,  A61K9/127 ,  A61L24/0094 ,  A61M37/0092 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/00 ,  B33Y70/00 ,  A61L2400/06 ,  A61M2205/058

Abstract: Techniques for deep tissue in vivo printing are described. Some implementations of the disclosure relate to a method that includes: obtaining a biopolymer mixture including prepolymer material and a crosslinking agent encapsulated in carrier particles; delivering the biopolymer mixture to a subcutaneous or deep tissue target location of a subject; and transmitting with a bioprinting device, via transcutaneous application, radiation to the subcutaneous or deep tissue target location, the radiation configured to cause the carrier particles to release at least some of the crosslinking agent, the released crosslinking agent configured to cause the prepolymer material to form into a gel or polymeric matrix.