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公开(公告)号：US11635064B1
公开(公告)日：2023-04-25
申请号：US17338393
申请日：2021-06-03
Applicant: California Institute of Technology , The Government of the United States of America, as represented by the Secretary of the Navy
Inventor： Emil P. Kartalov , Axel Scherer
IPC: A61F2/08 , H02N1/00 , B33Y80/00 , A61H1/02 , F15B21/06 , F03G7/06 , A61F2/70 , A61H3/00 , B25J9/10 , F15B15/10 , F15B13/044 , A61F2/48
Abstract: Artificial muscles comprising a body of dielectric elastomer, wherein the body contains a pair of microfluidic networks are presented. Each microfluidic network includes a plurality of channels fluidically coupled via a manifold. The channels of the microfluidic networks are interdigitated and filled with conductive fluid such that each set of adjacent channels functions as the electrodes of an electroactive polymer (EAP) actuator. By using the manifolds as compliant wiring to energize the electrodes, artificial muscles in accordance with the present disclosure mitigate some or all of the reliability problems associated with prior-art artificial muscles.
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公开(公告)号：US09920315B2
公开(公告)日：2018-03-20
申请号：US14996613
申请日：2016-01-15
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTHERN CALIFORNIA , CURATE BIOSCIENCES LLC
Inventor： Emil P. Kartalov , Cheng-Chung Lee , Paul Predki
CPC classification number: C12N15/1093 , B01L3/502707 , B01L2300/0816 , B01L2300/0887 , C12Q1/6853 , C12Q1/686 , C12Q1/6874 , C12Q2563/179
Abstract: Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation device described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation device can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation device can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation device can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device. Also included are methods for selectively isolating cellular material using the devices described herein, as are methods for biochemical analysis of individual regions of interest of cellular material using the devices described herein. Further included are methods of making masking arrays useful for the methods described herein. The micro-isolation devices can comprise a unique combination of barcodes in each microfluidics well, allowing two-dimensional mapping of genetic information.
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公开(公告)号：US11866768B2
公开(公告)日：2024-01-09
申请号：US16937464
申请日：2020-07-23
Applicant: California Institute of Technology
Inventor： Emil P. Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G01N33/48 , G01N33/50 , C12Q1/6825 , G16B25/00 , G16B5/00 , C12Q1/6851 , G16B25/20 , G16B40/10 , C12Q1/68 , G01N21/64 , G06F17/10 , G06F17/11 , G16B40/00
CPC classification number: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/6486 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10 , G06F17/10 , G06F17/11 , G16B40/00 , Y02A50/30 , C12Q1/6851 , C12Q2537/101 , C12Q2537/143 , C12Q2537/165 , C12Q2563/107
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：US10889863B2
公开(公告)日：2021-01-12
申请号：US16102583
申请日：2018-08-13
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Emil P. Kartalov , Aditya Rajagopal , Axel Scherer , Mark D. Goldberg
IPC: C12Q1/68 , C12Q1/70 , C12Q1/6883 , C12Q1/6851
Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Förster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.
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公开(公告)号：US20190032112A1
公开(公告)日：2019-01-31
申请号：US16051736
申请日：2018-08-01
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Emil P. Kartalov
Abstract: The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of kinetic signatures are provided. Further provided are methods and kits of nested PCR and PCR using limiting primers.
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Patent Agency Ranking
公开(公告)号：US20170362636A1
公开(公告)日：2017-12-21
申请号：US15623974
申请日：2017-06-15
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Emil P. Kartalov
CPC classification number: C12Q1/686 , B01J2219/00659 , C07H21/04 , G01N2021/6417
Abstract: The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of kinetic signatures are provided. Further provided are methods and kits of nested PCR and PCR using limiting primers.
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公开(公告)号：US09037209B2
公开(公告)日：2015-05-19
申请号：US13706668
申请日：2012-12-06
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SANOFI
Inventor： Axel Scherer , Remi Brouard, III , Emil P. Kartalov , Jingqing Huang
IPC: A61B5/1455 , A61B5/1459 , A61B3/10 , A61B5/145 , A61B5/00 , A61B5/20 , A61B5/1491 , A61B5/01
CPC classification number: A61B5/1459 , A61B3/10 , A61B5/0002 , A61B5/01 , A61B5/14507 , A61B5/1451 , A61B5/14546 , A61B5/1491 , A61B5/20 , A61B5/418 , A61B5/42 , A61B5/4337 , A61B5/6848 , A61B5/6852 , A61B5/6866 , A61B5/7278 , A61B2560/0219 , A61B2560/0233
Abstract: An implantable diagnostic device in accordance with the present disclosure includes a probe assembly that can be implemented in a variety of ways. A few example implementations include: a needle inside which is located a bio-sensor chip (the needle being insertable into a human being); a compact package containing the bio-sensor chip (the compact package configured for placement inside a catheter); or a silicon-based bio-sensor package configured for insertion into a vein.
Abstract translation: 根据本公开的可植入诊断装置包括可以以各种方式实现的探针组件。 一些示例性实现包括：位于其内的针，其位于生物传感器芯片（针可插入人体中）; 包含生物传感器芯片的紧凑型封装（被配置用于放置在导管内的紧凑封装）; 或被配置为插入静脉中的硅基生物传感器封装。
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公开(公告)号：US11060511B1
公开(公告)日：2021-07-13
申请号：US16442092
申请日：2019-06-14
Applicant: California Institute of Technology , The Government of the United States of America, as represented by the Secretary of the Navy
Inventor： Emil P. Kartalov , Axel Scherer
IPC: H02N1/00 , H02N1/06 , A61F2/08 , A61F2/70 , F03G7/06 , A61H3/00 , A61H1/02 , B25J9/10 , A61F2/48
Abstract: Artificial muscles comprising a body of dielectric elastomer, wherein the body contains a pair of microfluidic networks are presented. Each microfluidic network includes a plurality of channels fluidically coupled via a manifold. The channels of the microfluidic networks are interdigitated and filled with conductive fluid such that each set of adjacent channels functions as the electrodes of an electroactive polymer (EAP) actuator. By using the manifolds as compliant wiring to energize the electrodes, artificial muscles in accordance with the present disclosure mitigate some or all of the reliability problems associated with prior-art artificial muscles.
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公开(公告)号：US20210098076A1
公开(公告)日：2021-04-01
申请号：US16864744
申请日：2020-05-01
Applicant: California Institute of Technology
Inventor： Emil P. Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G16B25/00 , G16B5/00 , C12Q1/6851 , G16B25/20 , G16B40/10 , C12Q1/68 , G01N21/64 , C12Q1/6825
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：US20190034583A1
公开(公告)日：2019-01-31
申请号：US15914356
申请日：2018-03-07
Applicant: California Institute of Technology
Inventor： Emil P. Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G06F19/20 , G01N21/64 , C12Q1/68 , C12Q1/6825 , C12Q1/6851 , G06F19/12 , G06F17/10 , G06F17/11 , G06F19/24
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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