公开(公告)号：US20230024046A1

公开(公告)日：2023-01-26

申请号：US17878650

申请日：2022-08-01

Applicant: California Institute of Technology ,  Boyce Thompson Institute for Plant Research

Inventor： Andrea Choe ,  Paul W. Sternberg ,  Frank C. Schroeder ,  Stephan H. Von Reuss

IPC: C07H15/04 ,  A61K31/7028 ,  A01N37/36 ,  A61K31/454 ,  C07H15/08 ,  C07H15/10 ,  C07H15/18 ,  C07H15/26 ,  A01N43/16 ,  A01N43/38

Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.

公开(公告)号：US12220539B2

公开(公告)日：2025-02-11

申请号：US18896646

申请日：2024-09-25

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Tingtao Zhou ,  Xuan Wan ,  Paul W. Sternberg ,  Chiara Daraio ,  Zhengyu Huang ,  Zongyi Li ,  Zhiwei Peng ,  John F. Brady ,  Animashree Anandkumar

IPC: A61M25/00

Abstract: Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.

公开(公告)号：US10479813B2

公开(公告)日：2019-11-19

申请号：US16251750

申请日：2019-01-18

Applicant: California Institute of Technology ,  Boyce Thompson Institute for Plant Research

Inventor： Andrea Choe ,  Paul W. Sternberg ,  Frank C. Schroeder ,  Stephan H. Von Reuss

IPC: A61K31/7028 ,  C07H15/04 ,  A01N37/36 ,  A01N63/02 ,  A61K31/454 ,  C07H15/08 ,  C07H15/10 ,  C07H15/18 ,  C07H15/26 ,  A01N43/16 ,  A01N43/38 ,  C07D309/10

Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.

公开(公告)号：US12128189B2

公开(公告)日：2024-10-29

申请号：US18604162

申请日：2024-03-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Tingtao Zhou ,  Xuan Wan ,  Paul W. Sternberg ,  Chiara Daraio ,  Zhengyu Huang ,  Zongyi Li ,  Zhiwei Peng ,  John F. Brady ,  Animashree Anandkumar

IPC: A61M25/00

CPC classification number: A61M25/0017 ,  A61M2025/006

Abstract: Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.

公开(公告)号：US11673908B2

公开(公告)日：2023-06-13

申请号：US17878650

申请日：2022-08-01

Applicant: California Institute of Technology ,  Boyce Thompson Institute for Plant Research

Inventor： Andrea Choe ,  Paul W. Sternberg ,  Frank C. Schroeder ,  Stephan H. Von Reuss

IPC: A61K31/7028 ,  C07H15/04 ,  A01N37/36 ,  A61K31/454 ,  C07H15/08 ,  C07H15/10 ,  C07H15/18 ,  C07H15/26 ,  A01N43/16 ,  A01N43/38 ,  C07D309/10

CPC classification number: C07H15/04 ,  A01N37/36 ,  A01N43/16 ,  A01N43/38 ,  A61K31/454 ,  A61K31/7028 ,  C07H15/08 ,  C07H15/10 ,  C07H15/18 ,  C07H15/26 ,  C07D309/10

Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.

公开(公告)号：US20230026686A1

公开(公告)日：2023-01-26

申请号：US17941589

申请日：2022-09-09

Applicant: California Institute of Technology ,  Boyce Thompson Institute for Plant Research

Inventor： Andrea CHOE ,  Paul W. Sternberg ,  Frank C. Schroeder

IPC: A61K35/62 ,  A61P1/04 ,  A61K31/4178 ,  A61K31/7028 ,  A61K45/06 ,  A61P37/06 ,  A61P3/10 ,  A61K31/573 ,  G01N33/68 ,  A61K31/4439 ,  A61K31/56 ,  A61K31/7042 ,  A61K47/26

Abstract: A method of preventing or treating eosinophilic esophagitis (EoE) comprising administering a composition comprising ascr #7 is described.

公开(公告)号：US20220016182A1

公开(公告)日：2022-01-20

申请号：US17390096

申请日：2021-07-30

Applicant: California Institute of Technology ,  Boyce Thompson Institute for Plant Research

Inventor： Andrea Choe ,  Paul W. Sternberg ,  Frank C, Schroeder

IPC: A61K35/62 ,  A61P1/04 ,  A61K31/4178 ,  A61K31/7028 ,  A61K45/06 ,  A61P37/06 ,  A61P3/10 ,  A61K31/573 ,  G01N33/68 ,  A61K31/4439 ,  A61K31/56 ,  A61K31/7042 ,  A61K47/26

Abstract: The present invention relates to the use of ascr#7 for preventing or treating IL-6 and/or IL-1β-mediated diseases.

公开(公告)号：US20150329603A1

公开(公告)日：2015-11-19

申请号：US14711386

申请日：2015-05-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Erich M. Schwarz ,  Yan Hu ,  Igor Antoshechkin ,  Paul W. Sternberg ,  Raffi V. Aroian

IPC: C07K14/435

CPC classification number: C07K14/43536 ,  A61K39/00 ,  C07K14/4354

Abstract: In some aspects, the invention relates to compositions and methods for preventing or treating a hookworm infection. In some aspects, the invention relates to nucleic acids, peptides, proteins, antigens, and cells that encode, comprise, and/or express one or more hookworm amino acid sequences, e.g., for use in manufacturing a vaccine.

Abstract translation: 在一些方面，本发明涉及用于预防或治疗钩虫感染的组合物和方法。 在一些方面，本发明涉及编码，包含和/或表达一个或多个钩虫氨基酸序列的核酸，肽，蛋白质，抗原和细胞，例如用于制造疫苗。

公开(公告)号：US20240018177A1

公开(公告)日：2024-01-18

申请号：US18208629

申请日：2023-06-12

Applicant: California Institute of Technology ,  Boyce Thompson Institute for plant Research

Inventor： Andrea Choe ,  Paul W. Sternberg ,  Frank C. Schroeder ,  Stephan H. von Reuss

IPC: C07H15/04 ,  A61K31/7028 ,  A01N37/36 ,  A61K31/454 ,  C07H15/08 ,  C07H15/10 ,  C07H15/18 ,  C07H15/26 ,  A01N43/16 ,  A01N43/38

CPC classification number: C07H15/04 ,  A61K31/7028 ,  A01N37/36 ,  A61K31/454 ,  C07H15/08 ,  C07H15/10 ,  C07H15/18 ,  C07H15/26 ,  A01N43/16 ,  A01N43/38 ,  C07D309/10

Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.

公开(公告)号：US20200262856A1

公开(公告)日：2020-08-20

申请号：US16685375

申请日：2019-11-15

Applicant: California Institute of Technology ,  Boyce Thompson Institute for Plant Research

Inventor： Andrea Choe ,  Paul W. Sternberg ,  Frank C. Schroeder ,  Stephan H. Von Reuss

IPC: C07H15/04 ,  A01N63/10 ,  A01N43/38 ,  A01N43/16 ,  C07H15/26 ,  C07H15/18 ,  C07H15/10 ,  C07H15/08 ,  A61K31/454 ,  A01N37/36 ,  A61K31/7028

Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.