公开(公告)号：US09855233B2

公开(公告)日：2018-01-02

申请号：US14536299

申请日：2014-11-07

Applicant: CITY OF HOPE ,  Mahin Rahbar

Inventor： Samuel Rahbar ,  Timothy W. Synold ,  John Termini

IPC: G01N30/72 ,  A61K31/195 ,  G01N30/04 ,  G01N30/88 ,  A61K45/06 ,  A61N5/10

CPC classification number: A61K31/195 ,  A61K45/06 ,  A61N5/10 ,  G01N30/7233 ,  G01N30/7266 ,  G01N2030/045 ,  G01N2030/8827 ,  G01N2030/8868 ,  G01N2800/042

Abstract: Methods of quantifying a N2-carboxyethyl-2′-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of disorders, including diabetes and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels occurs using liquid chromatography electrospray ionization tandem mass spectrometry.

公开(公告)号：US10314284B2

公开(公告)日：2019-06-11

申请号：US15132902

申请日：2016-04-19

Applicant: City of Hope

Inventor： John Termini ,  Timothy R. O'Connor ,  Miro Rusnak ,  Yin S. Chan

IPC: A01K1/015 ,  A01K29/00 ,  A01K1/03

Abstract: A liner or pad is configured to be positioned on a bottom surface of a metabolic cage or to form a bottom of a metabolic cage so as to provide a surface that comfortably supports a confined animal in the cage. The pad provides a surface that prevents the mouse from directly contacting the wire mesh bottom of the cage.

公开(公告)号：US20180207116A1

公开(公告)日：2018-07-26

申请号：US15859188

申请日：2017-12-29

Applicant: CITY OF HOPE

Inventor： Samuel Rahbar ,  Timothy W. Synold ,  John Termini

IPC: A61K31/195 ,  G01N30/72 ,  G01N30/88 ,  A61K45/06 ,  A61N5/10 ,  G01N30/04

CPC classification number: A61K31/195 ,  A61K45/06 ,  A61N5/10 ,  G01N30/7233 ,  G01N30/7266 ,  G01N2030/045 ,  G01N2030/8827 ,  G01N2030/8868 ,  G01N2800/042

Abstract: Methods of quantifying N2-carboxyethyl-2′-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of disorders, including diabetes and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels occurs using liquid chromatography electrospray ionization tandem mass spectrometry.

公开(公告)号：US11835499B2

公开(公告)日：2023-12-05

申请号：US16944640

申请日：2020-07-31

Applicant: CITY OF HOPE

Inventor： Timothy W. Synold ,  John Termini ,  Sarah Shuck

IPC: G01N30/72 ,  G01N1/28 ,  G01N33/483 ,  G01N33/49 ,  G01N33/493 ,  H01J49/00 ,  G01N30/02

CPC classification number: G01N30/7266 ,  G01N1/28 ,  G01N33/4833 ,  G01N33/49 ,  G01N33/493 ,  H01J49/004 ,  G01N2001/2893 ,  G01N2030/027

Abstract: Methods of quantifying a N2-(1-carboxyethyl)-2′-deoxyguanosine (CEdG) and N2-(1-carboxyethyl)-guanosine (CEG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG and CEG levels before and after treatment. Measurement of CEdG and CEG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.

公开(公告)号：US11266618B2

公开(公告)日：2022-03-08

申请号：US15859188

申请日：2017-12-29

Applicant: CITY OF HOPE

Inventor： Samuel Rahbar ,  Timothy W. Synold ,  John Termini ,  Daniel Tamae ,  Gerald Wuenschell

IPC: A61K31/195 ,  G01N30/72 ,  G01N30/04 ,  G01N30/88 ,  A61K45/06 ,  A61N5/10

Abstract: Methods of quantifying N2-carboxyethyl-2′-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of disorders, including diabetes and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels occurs using liquid chromatography electrospray ionization tandem mass spectrometry.

公开(公告)号：US11179361B2

公开(公告)日：2021-11-23

申请号：US15887857

申请日：2018-02-02

Applicant: CITY OF HOPE

Inventor： Samuel Rahbar ,  Timothy W. Synold ,  John Termini ,  Gerald Wuenschell ,  Daniel Tamae

IPC: G01N30/72 ,  A61P3/10 ,  A61K31/195 ,  G01N33/68 ,  G01N30/88 ,  A61N5/10 ,  A61K45/06 ,  G01N30/04 ,  A61K31/121

Abstract: Methods of quantifying a N2-(1-carboxyethyl)-2′-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.

公开(公告)号：US20160309677A1

公开(公告)日：2016-10-27

申请号：US15132902

申请日：2016-04-19

Applicant: City of Hope

Inventor： John Termini ,  Timothy R. O' Connor ,  Miro Rusnak ,  Yin S. Chan

IPC: A01K1/015 ,  A01K1/03 ,  A01K29/00

CPC classification number: A01K1/0157 ,  A01K1/0151 ,  A01K1/031 ,  A01K23/005 ,  A01K29/005

Abstract: A liner or pad is configured to be positioned on a bottom surface of a metabolic cage or to form a bottom of a metabolic cage so as to provide a surface that comfortably supports a confined animal in the cage. The pad provides a surface that prevents the mouse from directly contacting the wire mesh bottom of the cage.

Abstract translation: 衬垫或衬垫构造成定位在代谢笼的底表面上或形成代谢笼的底部，以便提供舒适地支撑笼中的限制动物的表面。 垫提供了一个防止鼠标直接接触保持架的丝网底部的表面。