公开(公告)号：US12265086B2

公开(公告)日：2025-04-01

申请号：US17668456

申请日：2022-02-10

Applicant: Colgate-Palmolive Company

Inventor： Dandan Chen ,  Harsh Mahendra Trivedi ,  James Masters ,  Richard P. Darveau ,  Jeffrey S. Mclean

IPC: G01N33/68

Abstract: Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. Some methods are based on IL-1β levels in the individual's GCF at the site of inflammation. Some methods are based on MIF and/or CCL-1 levels in the individual's GCF in healthy tissue distant from the site of inflammation. Some disclosed methods are based on temporal differences in IL-8, IL-6 and/or TNFα levels in the individual's GCF in healthy tissue distant from the site of inflammation during the development of plaque induced inflammation. Methods of treating an individual who has gingivitis and methods of preventing gingivitis are also provided. The treatment and prevention methods comprise determining if individual is a slow gingivitis responder or a high gingivitis responder and applying oral care compositions to the individual's oral cavity.

公开(公告)号：US10675455B2

公开(公告)日：2020-06-09

申请号：US15426361

申请日：2017-02-07

Applicant: Colgate-Palmolive Company

Inventor： Patrik Johansson ,  Harsh Mahendra Trivedi ,  Douglas Hohlbein

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/32 ,  A61N1/26 ,  A61C17/22 ,  C25B1/26 ,  C25B9/06 ,  C25B1/28 ,  A46B15/00 ,  A61C17/16 ,  A61N1/20

Abstract: An oral care implement having conductive protrusions. In one embodiment, the oral care implement includes a handle and a head coupled to the handle. Furthermore, the oral care implement includes a power source. A plurality of conductive protrusions may be electrically coupled to the power source. The plurality of conductive protrusions may include a base proximate the head and a distal end spaced from the head. Furthermore, at least one of the conductive protrusions may taper from the base to the distal end.

公开(公告)号：US11573228B2

公开(公告)日：2023-02-07

申请号：US17309892

申请日：2019-12-17

Applicant: Colgate-Palmolive Company

Inventor： Camille Zenobia ,  Harsh Mahendra Trivedi ,  Ying Yang

IPC: G01N33/50 ,  G01N33/68 ,  G01N33/569

Abstract: Methods of determining one or more ratios of chemokines in gingival crevicular fluid of an individual selected from the group consisting of: MIF:MIP1a, MIF:CXCL1; MIF:CXCL5; M1F:CXCL8; MIF:CXCL2; and MIF:CXCL6 and methods of identifying an individual as having gingivitis comprising determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Methods of treating individuals who are identified as having gingivitis by determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Also disclosed are methods of monitoring the treatment individuals who have gingivitis.

公开(公告)号：US11116708B2

公开(公告)日：2021-09-14

申请号：US16758434

申请日：2017-12-19

Applicant: Colgate-Palmolive Company

Inventor： Shujiang Cheng ,  Zeenat Nabi ,  Laurence Du-Thumm ,  Qiang Wu ,  Jane Ong ,  Halyna Siomyk ,  Harsh Mahendra Trivedi ,  James Masters ,  Chi-Yuan Cheng ,  Donghui Wu

IPC: A61K8/27 ,  A61K8/49 ,  A61K8/60 ,  A61Q15/00 ,  A61Q19/08 ,  A61Q19/02 ,  A61Q11/00

Abstract: Personal care compositions including a naringin:zinc complex and methods for preparing and using the same are provided. The personal care compositions may include a carrier and a naringin:zinc complex having a 2:1 naringin to zinc molar ratio.

公开(公告)号：US10376149B2

公开(公告)日：2019-08-13

申请号：US15646257

申请日：2017-07-11

Applicant: Colgate-Palmolive Company

Inventor： Michael Pacelli ,  Hrebesh Molly Subhash ,  Michael Fitzgerald ,  Harsh Mahendra Trivedi

IPC: A61C3/00 ,  A61B5/00 ,  A61C17/22

Abstract: An oral care evaluation system may include: a light source configured to emit a spectrum of light which induces fluorescence in an organic compound, the light source illuminating soft oral tissue within an oral cavity; an image sensor receiving light generated by fluorescence of the organic compound on the soft oral tissue, the image sensor generating image data for an image of the oral tissue, the image comprising a plurality of pixels; and an image processor receiving the image data from the image sensor and programmed to evaluate oral hygiene of the soft oral tissue by assessing an attribute of each pixel in the image.

公开(公告)号：US12064618B2

公开(公告)日：2024-08-20

申请号：US16864218

申请日：2020-05-01

Applicant: Colgate-Palmolive Company

Inventor： Patrik Johansson ,  Harsh Mahendra Trivedi ,  Douglas Hohlbein

IPC: A61N1/05 ,  A46B15/00 ,  A61C17/16 ,  A61C17/22 ,  A61N1/26 ,  A61N1/32 ,  C25B1/26 ,  C25B1/28 ,  C25B1/29 ,  C25B9/17 ,  A61N1/20

CPC classification number: A61N1/0548 ,  A46B15/0022 ,  A61C17/16 ,  A61C17/222 ,  A61N1/26 ,  A61N1/322 ,  A61N1/326 ,  C25B1/26 ,  C25B1/28 ,  C25B1/29 ,  C25B9/17 ,  A61N1/205

Abstract: An oral care implement having conductive protrusions. In one embodiment, the oral care implement includes a handle and a head coupled to the handle. Furthermore, the oral care implement includes a power source. A plurality of conductive protrusions may be electrically coupled to the power source. The plurality of conductive protrusions may include a base proximate the head and a distal end spaced from the head. Furthermore, at least one of the conductive protrusions may taper from the base to the distal end.

公开(公告)号：US11931443B2

公开(公告)日：2024-03-19

申请号：US17214731

申请日：2021-03-26

Applicant: Colgate-Palmolive Company

Inventor： Carlo Daep ,  Harsh Mahendra Trivedi ,  Paul Thomson

IPC: A61K8/43 ,  A61K8/21 ,  A61K8/27 ,  A61Q11/00 ,  A61Q11/02

CPC classification number: A61K8/43 ,  A61K8/21 ,  A61K8/27 ,  A61Q11/00 ,  A61Q11/02

Abstract: This invention relates to oral care compositions comprising guanidine, zinc citrate and zinc oxide, and a fluoride source, as well as to methods of using and of making these compositions.

公开(公告)号：US11318003B2

公开(公告)日：2022-05-03

申请号：US16520412

申请日：2019-07-24

Applicant: Colgate-Palmolive Company

Inventor： Elizabeth Kelly Gittins ,  Harsh Mahendra Trivedi ,  John Gatzemeyer ,  Eduardo Jimenez ,  Sharon Kennedy

IPC: A61B5/00 ,  A61C19/04 ,  A46B15/00 ,  G16H10/60 ,  A61B5/0205 ,  A61B5/145 ,  A61B10/00

Abstract: A computer-implemented method including deriving a health profile of a user from a sample taken from the user and displaying a representation of the health profile on a display, wherein the representation of the health profile includes a list of undesirable oral health characteristics that are detectable from the sample. The representation of the health profile may also include a list of desirable oral health characteristics that are detectable from the sample. Furthermore, a user may select one of the undesirable health characteristics, and in response an indication of historical values associated within he selected one of the undesirable health characteristics may be displayed on the display.

公开(公告)号：US10773105B2

公开(公告)日：2020-09-15

申请号：US16425312

申请日：2019-05-29

Applicant: Colgate-Palmolive Company

Inventor： Ying Yang ,  Dandan Chen ,  Robert D'Ambrogio ,  Paul Thomson ,  Harsh Mahendra Trivedi ,  Michael Prencipe ,  James Masters ,  Stanislav Jaracz

IPC: A61Q11/00 ,  A61K8/34 ,  A61K8/35 ,  A61K8/365 ,  A61Q17/00 ,  A61K8/21 ,  A61K8/22 ,  A61K8/27 ,  A61K8/97 ,  A61K36/9068 ,  A61K45/06

Abstract: This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.

公开(公告)号：US09597496B1

公开(公告)日：2017-03-21

申请号：US14885502

申请日：2015-10-16

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Patrik Johansson ,  Harsh Mahendra Trivedi ,  Douglas Joseph Hohlbein

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/32 ,  A61N1/20 ,  A61N1/26

CPC classification number: A61N1/0548 ,  A46B15/0022 ,  A61C17/16 ,  A61C17/222 ,  A61N1/205 ,  A61N1/26 ,  A61N1/322 ,  A61N1/326 ,  C25B1/26 ,  C25B1/28 ,  C25B1/285 ,  C25B9/06

Abstract: In some embodiments, an oral care implement includes a housing, a power source, and a plurality of conductive protrusions extending from a surface of the housing. Also disclosed are methods of using the oral care implement, for example, for treating conditions in the oral cavity.