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公开(公告)号：US20200072829A1
公开(公告)日：2020-03-05
申请号：US16668005
申请日：2019-10-30
Inventor： Francisco Javier TAMAYO DE MIGUEL , Priscila MONTEIRO KOSAKA , Valerio PINI , Montserrat CALLEJA GOMÉZ , Jose Jaime RUZ MARTINEZ , Daniel RAMOS VEGA , Maria Ujue GONZALEZ SAGARDOY
IPC: G01N33/543 , G01N21/47 , G01N21/59 , G01N21/77 , G01N21/65 , G01N21/552
Abstract: The present invention relates to a system for biodetection applications comprising two basic elements, a substrate with a functionalized surface and a nanoparticle, the system being capable of enhancing the plasmonic effect of the nanoparticle. The invention also relates to a biosensor incorporating such system, in addition to the method for detecting and quantifying a target analyte selected in a sample using such system. Finally, the invention relates to a device which can detect the enhanced optoplasmonic effect of the nanoparticles by means of the system of the invention or by combining the detection of such optoplasmonic effect with the analysis of the changes in the mechanical characteristics in the substrate.
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公开(公告)号：US20170205405A1
公开(公告)日：2017-07-20
申请号：US15315029
申请日：2015-06-02
Inventor： Francisco Javier TAMAYO DE MIGUEL , Priscila MONTEIRO KOSAKA , Valerio PINI , Montserrat CALLEJA GOMÉZ , Jose Jaime RUZ MARTINEZ , Daniel RAMOS VEGA , Maria Ujue GONZALEZ SAGARDOY
IPC: G01N33/543 , G01N21/47 , G01N21/59 , G01N21/77
CPC classification number: G01N33/54346 , G01N21/47 , G01N21/554 , G01N21/59 , G01N21/658 , G01N21/77 , G01N21/7703 , G01N33/54373 , G01N2021/5903
Abstract: The present invention relates to a system for biodetection applications comprising two basic elements, a substrate with a functionalized surface and a nanoparticle, the system being capable of enhancing the plasmonic effect of the nanoparticle. The invention also relates to a biosensor incorporating such system, in addition to the method for detecting and quantifying a target analyte selected in a sample using such system. Finally, the invention relates to a device which can detect the enhanced optoplasmonic effect of the nanoparticles by means of the system of the invention or by combining the detection of such optoplasmonic effect with the analysis of the changes in the mechanical characteristics in the substrate.
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公开(公告)号：US20230332994A1
公开(公告)日：2023-10-19
申请号：US18035119
申请日：2021-10-21
Inventor： Alberto MARTÍN PÉREZ , Daniel RAMOS VEGA , Montserrat CALLEJA GÓMEZ , Francisco Javier TAMAYO DE MIGUEL
IPC: G01N15/02 , G01N15/14 , G01N33/487
CPC classification number: G01N15/0211 , G01N15/1434 , G01N33/487
Abstract: The method uses a suspended resonating microcapillary device, and obtains simultaneously three parameters of the analytes: mass, size and refractive index, enabling the unequivocal classification of the analytes flowing in real time, based on the resonance frequency displacement and the change in reflectivity of the transparent microcapillary. The method comprises the stages of: the obtaining of a measurement of the reflectivity of the sample analytes within the capillary at each moment in time; the obtaining of a mechanical reference signal (Tt) of the change in resonance frequency of the microcapillary caused by the sample analytes over time; and the detection of the passage of the particle through an area of the capillary, and the obtaining of the points of passage of the ends of the analytes through the centre of the illuminated area, obtaining an optical signal ΔT.
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公开(公告)号：US20180017444A1
公开(公告)日：2018-01-18
申请号：US15517809
申请日：2015-10-08
Inventor： Valerio PINI , Priscila MONTEIRO KOSAKA , Francisco Javier TAMAYO DE MIGUEL , Montserrat CALLEJA GOMEZ , Daniel RAMOS VEGA , Oscar MALVAR VIDAL , Jose Jaime RUZ MARTINEZ , Mario ENCINAR DEL POZO
CPC classification number: G01J3/2803 , G01J3/0208 , G01J3/12 , G01J3/28 , G01J3/2823 , G01J2003/104 , G01J2003/106 , G01J2003/2813 , G01J2003/282 , G01J2003/2826 , G01N21/27 , G02B21/00
Abstract: The invention relates to a spectrophotometer, especially a spectrophotometer that can carry out simultaneous analysis at different points on the same sample (4), with a high spatial resolution and without requiring a mechanical system for physical scanning along the sample. This is obtained by the provision of means for processing the light received by the photodetectors (5), said processing means having a correlation wherein each of the photodetectors (5) corresponds to a spatial point on the sample (4).In the case of dark field applications, the present invention ensures the standardization of the data using the same measure.
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