公开(公告)号：US20150375153A1

公开(公告)日：2015-12-31

申请号：US14852811

申请日：2015-09-14

Applicant: CRITITECH, INC.

Inventor： Greg S. JOHNSON ,  Bala SUBRAMANIAM ,  Fenhui NIU ,  Jahna C. ESPINOSA

IPC: B01D46/00 ,  B01J19/24 ,  A61K9/16 ,  B01J19/10 ,  B01D9/00 ,  B01D29/66

CPC classification number: B01J19/24 ,  A61K9/1688 ,  B01D9/0013 ,  B01D9/0054 ,  B01D29/661 ,  B01J3/008 ,  B01J4/002 ,  B01J8/006 ,  B01J2219/00051 ,  B01J2219/00162 ,  B01J2219/00164 ,  Y02P20/544

Abstract: An equipment assembly for preparing, harvesting and collecting particles is disclosed. The assembly comprises a tandem filter system with one or more high pressure filters, one or more low pressure filters and one or more collection vessel. Particles can be prepared, harvested and collected continuously, semi-continuously or in a batch-type operation. A tandem filter system and its method of use are also disclosed. Particles made with the assembly and according the instant methods are also disclosed. The assembly provides improved particle harvesting and collection over other systems and permits continuous particle formation, in particular by dispersion of a solute-containing process fluid within a supercritical anti-solvent.

Abstract translation: 公开了一种用于制备，收集和收集颗粒的设备组件。 组件包括具有一个或多个高压过滤器，一个或多个低压过滤器和一个或多个收集容器的串联过滤器系统。 可以连续，半连续或间歇式操作来制备，收获和收集颗粒。 还公开了一种串联过滤系统及其使用方法。 还公开了使用组装制成的颗粒和根据即时方法制备的颗粒。 该组件在其它系统上提供改进的颗粒收获和收集，并允许连续的颗粒形成，特别是通过在超临界反溶剂中分散含溶质的工艺流体。

公开(公告)号：US20180221849A1

公开(公告)日：2018-08-09

申请号：US15894513

申请日：2018-02-12

Applicant: CRITITECH, INC.

Inventor： Greg S. JOHNSON ,  Bala SUBRAMANIAM ,  Fenghui NIU ,  Jahna C. ESPINOSA ,  Charles J. DECEDUE ,  Gary E. CLAPP ,  Jacob M. SITTENAUER

IPC: B01J19/24 ,  B01D9/00 ,  A61K9/16 ,  B01D29/66 ,  B01J3/00 ,  B01J4/00 ,  B01J8/00

CPC classification number: B01J19/24 ,  A61K9/1688 ,  B01D9/0013 ,  B01D9/0054 ,  B01D29/661 ,  B01J3/008 ,  B01J4/002 ,  B01J8/006 ,  B01J2219/00051 ,  B01J2219/00162 ,  B01J2219/00164 ,  Y02P20/544

Abstract: An equipment assembly for preparing, harvesting and collecting particles is disclosed. The assembly comprises a tandem filter system with one or more high pressure filters, one or more low pressure filters and one or more collection vessel. Particles can be prepared, harvested and collected continuously, semi-continuously or in a batch-type operation. A tandem filter system and its method of use are also disclosed. Particles made with the assembly and according the instant methods are also disclosed. The assembly provides improved particle harvesting and collection over other systems and permits continuous particle formation, in particular by dispersion of a solute-containing process fluid within a supercritical anti-solvent.

公开(公告)号：US20180125783A1

公开(公告)日：2018-05-10

申请号：US15573157

申请日：2016-06-06

Applicant: CRITITECH, INC.

Inventor： Bala SUBRAMANIAM ,  Jahna ESPINOSA ,  Gregory F. JOHNSON ,  Jacob M. SITTENAUER ,  Joseph S. FARTHING

IPC: A61K9/16 ,  A61K9/51 ,  A61K31/337 ,  A61K9/10 ,  A61K9/00 ,  B01J2/04 ,  B01J3/00 ,  B01J3/02 ,  B05B1/34 ,  B05B13/02

CPC classification number: A61K31/337 ,  A61J3/02 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1605 ,  A61K9/1682 ,  A61K9/1688 ,  A61K9/5192 ,  B01D46/24 ,  B01D2271/02 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  B01J4/002 ,  B01J19/10 ,  B01J19/26 ,  B05B1/3489 ,  B05B13/0278 ,  B05D2401/90

Abstract: The present disclosure provides an apparatus and methods of use for isolating particles. An example apparatus includes (a) a vessel defining a pressurizable chamber, wherein the vessel includes a distal end and a proximal end, (b) an inlet of the pressurizable chamber at the proximal end of the vessel, (c) a nozzle positioned within the pressurizable chamber, wherein the nozzle includes an inlet tube in fluid communication with the inlet of the pressurizable chamber, wherein the nozzle includes an outlet aperture, wherein the nozzle is adjustable to alter a distance between the proximal end of the vessel and the outlet aperture of the nozzle, and wherein the nozzle is adjustable to alter an angle between a longitudinal axis of the vessel and a longitudinal axis of the nozzle, and (d) an outlet of the pressurizable chamber at the distal end of the vessel.

公开(公告)号：US20180116910A1

公开(公告)日：2018-05-03

申请号：US15573091

申请日：2016-06-06

Applicant: CRITITECH, INC.

Inventor： Bala SUBRAMANIAM ,  Jahna ESPINOSA ,  Greg JOHNSON ,  Jacob M. SITTENAUER ,  Joseph S. FARTHING

IPC: A61J3/02 ,  A61K31/337 ,  A61K9/14 ,  B01D46/24

Abstract: The present disclosure provides an apparatus and methods of use for collecting particles. An example collection device includes (a) a vessel defining a chamber, wherein the vessel includes a distal end and a proximal end, (b) an inlet port extending from the proximal end of the vessel, wherein the inlet port is in fluid communication with the chamber, and (c) an outlet port extending from the proximal end of the vessel, wherein the inlet port is in fluid communication with the chamber, and wherein the outlet port includes a porous material positioned between the chamber and the outlet port.