公开(公告)号：US20160374953A1

公开(公告)日：2016-12-29

申请号：US15261108

申请日：2016-09-09

Applicant: CRITITECH, INC.

Inventor： Michael BALTEZOR ,  Joseph FARTHING ,  Jake SITTENAUER ,  Jahna ESPINOSA ,  Samuel CAMPBELL ,  Matthew MCCLOREY ,  Julia K. FISCHER ,  Mark D. WILLIAMS

IPC: A61K9/51 ,  A61K31/337

CPC classification number: A61K31/337 ,  A61J3/02 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1605 ,  A61K9/1682 ,  A61K9/1688 ,  A61K9/5192 ,  B01D46/24 ,  B01D2271/02 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  B01J4/002 ,  B01J19/10 ,  B01J19/26 ,  B05B1/3489 ,  B05B13/0278 ,  B05D2401/90

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

Abstract translation: 提供的组合物包括具有至少95重量％的紫杉烷或其药学上可接受的盐，其中颗粒的平均堆积密度为约0.050g / cm 3至约0.15g / cm 3，和/或比表面积 面积（SSA）至少为18m2 / g，20m2 / g，25m2 / g，30m2 / g，32m2 / g，34m2 / g或35m2 / g。 还提供了制备和使用这些组合物的方法。

公开(公告)号：US20180169058A1

公开(公告)日：2018-06-21

申请号：US15895197

申请日：2018-02-13

Applicant: CRITITECH, INC.

Inventor： Michael BALTEZOR ,  Joseph FARTHING ,  Jake SITTENAUER ,  Jahna ESPINOSA ,  Samuel CAMPBELL ,  Matthew MCCLOREY ,  Julia K. FISCHER ,  Mark D. WILLIAMS ,  Gary CLAPP

IPC: A61K31/337 ,  B01J3/02 ,  A61K9/16 ,  B01J3/00

CPC classification number: A61K31/337 ,  A61J3/02 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1605 ,  A61K9/1682 ,  A61K9/1688 ,  A61K9/5192 ,  B01D46/24 ,  B01D2271/02 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  B01J4/002 ,  B01J19/10 ,  B01J19/26 ,  B05B1/3489 ,  B05B13/0278 ,  B05D2401/90

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US20200163928A1

公开(公告)日：2020-05-28

申请号：US16776919

申请日：2020-01-30

Applicant: CRITITECH, INC.

Inventor： Michael BALTEZOR ,  Joseph FARTHING ,  Jake SITTENAUER ,  Jahna ESPINOSA ,  Samuel CAMPBELL ,  Matthew MCCLOREY ,  Julia K. FISCHER ,  Mark D. WILLIAMS ,  Gary E. CLAPP

IPC: A61K31/337 ,  A61K9/51 ,  A61K9/16 ,  B05B13/02 ,  A61K9/10 ,  A61K9/00 ,  A61J3/02 ,  B01J3/00 ,  B05B1/34 ,  B01D46/24 ,  B01J4/00 ,  B01J19/10 ,  B01J2/04 ,  A61K9/14 ,  B01J19/26 ,  B01J3/02

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US20180125783A1

公开(公告)日：2018-05-10

申请号：US15573157

申请日：2016-06-06

Applicant: CRITITECH, INC.

Inventor： Bala SUBRAMANIAM ,  Jahna ESPINOSA ,  Gregory F. JOHNSON ,  Jacob M. SITTENAUER ,  Joseph S. FARTHING

IPC: A61K9/16 ,  A61K9/51 ,  A61K31/337 ,  A61K9/10 ,  A61K9/00 ,  B01J2/04 ,  B01J3/00 ,  B01J3/02 ,  B05B1/34 ,  B05B13/02

CPC classification number: A61K31/337 ,  A61J3/02 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1605 ,  A61K9/1682 ,  A61K9/1688 ,  A61K9/5192 ,  B01D46/24 ,  B01D2271/02 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  B01J4/002 ,  B01J19/10 ,  B01J19/26 ,  B05B1/3489 ,  B05B13/0278 ,  B05D2401/90

Abstract: The present disclosure provides an apparatus and methods of use for isolating particles. An example apparatus includes (a) a vessel defining a pressurizable chamber, wherein the vessel includes a distal end and a proximal end, (b) an inlet of the pressurizable chamber at the proximal end of the vessel, (c) a nozzle positioned within the pressurizable chamber, wherein the nozzle includes an inlet tube in fluid communication with the inlet of the pressurizable chamber, wherein the nozzle includes an outlet aperture, wherein the nozzle is adjustable to alter a distance between the proximal end of the vessel and the outlet aperture of the nozzle, and wherein the nozzle is adjustable to alter an angle between a longitudinal axis of the vessel and a longitudinal axis of the nozzle, and (d) an outlet of the pressurizable chamber at the distal end of the vessel.

公开(公告)号：US20170224650A1

公开(公告)日：2017-08-10

申请号：US15499397

申请日：2017-04-27

Applicant: CRITITECH, INC.

Inventor： Michael BALTEZOR ,  Joseph FARTHING ,  Jake SITTENAUER ,  Jahna ESPINOSA ,  Samuel CAMPBELL ,  Matthew MCCLOREY ,  Julia K. FISCHER ,  Mark D. WILLIAMS

IPC: A61K31/337 ,  B01J3/00 ,  B01J3/02 ,  A61K9/16

CPC classification number: A61K31/337 ,  A61J3/02 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1605 ,  A61K9/1682 ,  A61K9/1688 ,  A61K9/5192 ,  B01D46/24 ,  B01D2271/02 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  B01J4/002 ,  B01J19/10 ,  B01J19/26 ,  B05B1/3489 ,  B05B13/0278 ,  B05D2401/90

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US20210393569A1

公开(公告)日：2021-12-23

申请号：US17467655

申请日：2021-09-07

Applicant: CRITITECH, INC.

Inventor： Michael BALTEZOR ,  Joseph FARTHING ,  Jake SITTENAUER ,  Jahna ESPINOSA ,  Samuel CAMPBELL ,  Matthew MCCLOREY ,  Julia K. FISCHER ,  Mark D. WILLIAMS ,  Gary E. CLAPP

IPC: A61K31/337 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  B01J19/10 ,  B01J19/26 ,  B01J2/04 ,  B01J3/00 ,  B01J4/00 ,  A61K9/51 ,  A61J3/02 ,  B01D46/24 ,  B01J3/02 ,  B05B1/34 ,  B05B13/02

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US20210000786A1

公开(公告)日：2021-01-07

申请号：US17023635

申请日：2020-09-17

Applicant: CRITITECH, INC.

Inventor： Michael BALTEZOR ,  Joseph FARTHING ,  Jake SITTENAUER ,  Jahna ESPINOSA ,  Samuel CAMPBELL ,  Matthew MCCLOREY ,  Julia K. FISCHER ,  Mark D. WILLIAMS ,  Gary E. CLAPP

IPC: A61K31/337 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  B01J19/10 ,  B01J19/26 ,  B01J2/04 ,  B01J3/00 ,  B01J4/00 ,  A61K9/51 ,  A61J3/02 ,  B01D46/24 ,  B01J3/02 ,  B05B1/34 ,  B05B13/02

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US20180116910A1

公开(公告)日：2018-05-03

申请号：US15573091

申请日：2016-06-06

Applicant: CRITITECH, INC.

Inventor： Bala SUBRAMANIAM ,  Jahna ESPINOSA ,  Greg JOHNSON ,  Jacob M. SITTENAUER ,  Joseph S. FARTHING

IPC: A61J3/02 ,  A61K31/337 ,  A61K9/14 ,  B01D46/24

Abstract: The present disclosure provides an apparatus and methods of use for collecting particles. An example collection device includes (a) a vessel defining a chamber, wherein the vessel includes a distal end and a proximal end, (b) an inlet port extending from the proximal end of the vessel, wherein the inlet port is in fluid communication with the chamber, and (c) an outlet port extending from the proximal end of the vessel, wherein the inlet port is in fluid communication with the chamber, and wherein the outlet port includes a porous material positioned between the chamber and the outlet port.

公开(公告)号：US20160354336A1

公开(公告)日：2016-12-08

申请号：US15174505

申请日：2016-06-06

Applicant: CRITITECH, INC.

Inventor： Michael BALTEZOR ,  Joseph FARTHING ,  Jake SITTENAUER ,  Jahna ESPINOSA ,  Samuel CAMPBELL ,  Matthew MCCLOREY ,  Julia K. FISCHER ,  Mark D. WILLIAMS

IPC: A61K31/337 ,  A61K9/16

CPC classification number: A61K31/337 ,  A61J3/02 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1605 ,  A61K9/1682 ,  A61K9/1688 ,  A61K9/5192 ,  B01D46/24 ,  B01D2271/02 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  B01J4/002 ,  B01J19/10 ,  B01J19/26 ,  B05B1/3489 ,  B05B13/0278 ,  B05D2401/90

Abstract: Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

Abstract translation: 提供的组合物包括具有至少95重量％的紫杉烷或其药学上可接受的盐，其中颗粒的平均堆积密度为约0.050g / cm 3至约0.15g / cm 3，和/或比表面积 面积（SSA）至少为18m2 / g，20m2 / g，25m2 / g，30m2 / g，32m2 / g，34m2 / g或35m2 / g。 还提供了制备和使用这些组合物的方法。