公开(公告)号：US20140048481A1

公开(公告)日：2014-02-20

申请号：US14065210

申请日：2013-10-28

Applicant: California Institute of Technology

Inventor： Chi-Yuan Shih ,  Yu-Chong Tai ,  Jun Xie ,  Darron K. Young ,  Po-Jui Chen

IPC: B01D15/22

CPC classification number: B01D15/22 ,  G01N30/02 ,  G01N30/461 ,  G01N30/466 ,  G01N30/6095 ,  G01N30/78 ,  G01N30/96 ,  G01N2030/524 ,  Y10T29/49826 ,  B01D15/363 ,  B01D15/3804 ,  B01D15/362 ,  B01D15/34 ,  B01D15/325 ,  B01D15/361

Abstract: Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process.

Abstract translation: 使用集成色谱系统和设备实时监测分析物的系统和方法。 集成的微流体液相色谱装置和系统包括集成到单个底物中的多个分离柱。 使用这样的器件，可以同时执行多个样本的并行分析和/或可以在单个芯片或衬底上同时执行单个样本的顺序分析。 该装置和系统非常适用于高压液相色谱（HPLC）应用。 包括嵌入式聚对二甲苯通道的HPLC芯片和器件可以使用单一掩模工艺制造。

公开(公告)号：US08721892B2

公开(公告)日：2014-05-13

申请号：US14065210

申请日：2013-10-28

Applicant: California Institute of Technology

Inventor： Chi-Yuan Shih ,  Yu-Chong Tai ,  Jun Xie ,  Darron K. Young ,  Po-Jui Chen

IPC: B01D15/08 ,  G01N30/02 ,  C02F1/28

CPC classification number: B01D15/22 ,  G01N30/02 ,  G01N30/461 ,  G01N30/466 ,  G01N30/6095 ,  G01N30/78 ,  G01N30/96 ,  G01N2030/524 ,  Y10T29/49826 ,  B01D15/363 ,  B01D15/3804 ,  B01D15/362 ,  B01D15/34 ,  B01D15/325 ,  B01D15/361

Abstract: Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process.

Abstract translation: 使用集成色谱系统和设备实时监测分析物的系统和方法。 集成的微流体液相色谱装置和系统包括集成到单个底物中的多个分离柱。 使用这样的器件，可以同时执行多个样本的并行分析和/或可以在单个芯片或衬底上同时执行单个样本的顺序分析。 该装置和系统非常适用于高压液相色谱（HPLC）应用。 包括嵌入式聚对二甲苯通道的HPLC芯片和器件可以使用单一掩模工艺制造。