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公开(公告)号：US20200148645A1
公开(公告)日：2020-05-14
申请号：US16741559
申请日：2020-01-13
Applicant: City of Hope , California Institute of Technology
Inventor： Binghui Shen , Judith Campbell , Li Zheng , Hongzhi Li , David Horne , Jun Xie , Kenneth Karanja
IPC: C07D215/56 , A61K45/06 , A61K31/47
Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
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公开(公告)号：US20180134664A1
公开(公告)日：2018-05-17
申请号：US15866268
申请日：2018-01-09
Applicant: City of Hope , California Institute of Technology
Inventor： Binghui Shen , Judith Campbell , Li Zheng , Hongzhi Li , David Horne , Jun Xie , Kenneth Karanja
IPC: C07D215/56 , A61K31/47 , A61K45/06
CPC classification number: C07D215/56 , A61K31/47 , A61K45/06
Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
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公开(公告)号：US09932310B2
公开(公告)日：2018-04-03
申请号：US15428021
申请日：2017-02-08
Applicant: City of Hope , California Institute of Technology
Inventor： Binghui Shen , Judith Campbell , Li Zheng , Hongzhi Li , David Horne , Jun Xie , Kenneth Karanja
IPC: C07D215/00 , C07D215/56 , A61K45/06 , A61K31/47
CPC classification number: C07D215/56 , A61K31/47 , A61K45/06
Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
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公开(公告)号：US11780815B2
公开(公告)日：2023-10-10
申请号：US17515252
申请日：2021-10-29
Applicant: City of Hope , California Institute of Technology
Inventor： Binghui Shen , Judith Campbell , Li Zheng , Hongzhi Li , David Horne , Jun Xie , Kenneth Karanja
IPC: C07D215/56 , A61K31/47 , A61K45/06
CPC classification number: C07D215/56 , A61K31/47 , A61K45/06
Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
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5.发明授权IC-processed polymer nano-liquid chromatography system on-a-chip and method of making it 有权IC加工聚合物纳米液相色谱系统芯片及其制备方法公开(公告)号：US09288915B2
公开(公告)日：2016-03-15
申请号：US13680030
申请日：2012-11-17
Applicant: City of Hope , California Institute of Technology
Inventor： Yu-Chong Tai , Qing He , Jun Xie , Changlin Pang , Terry D. Lee , Damien Rodger , Matthieu Liger
CPC classification number: H05K3/284 , G01N30/6047 , G01N30/6095 , G01N2030/645 , G03F1/80 , G01N2030/625
Abstract: Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanoliter/picoliter-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.
Abstract translation: 根据本发明的实施方案涉及集成在片上的填充柱纳米液相色谱（nano-LC）系统及其制造和使用方法。 微制造的芯片包括以常规用于形成集成电路的方法兼容的工艺制造的柱，过滤器，注射器和检测器。 该柱可以填充有用于各种不同固定相的载体，以允许不同形式的纳米LC的性能，包括但不限于反相，正相，吸附，尺寸排阻，亲和力和离子色谱。 交叉通道注射器在柱入口处注入纳升/皮升体积的样品塞。 集成在色谱柱出口处的电化学/电导率传感器测量分离信号。 自对准的通道加强技术提高了微流体系统的压力等级，使其能够承受通常用于高效液相色谱（HPLC）的高压。 使用离子交换纳米LC成功地证明了在水中阴离子的混合物的片上样品注入，分离和检测。
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Patent Agency Ranking
6.发明授权公开(公告)号：US08721892B2
公开(公告)日：2014-05-13
申请号：US14065210
申请日：2013-10-28
Applicant: California Institute of Technology
Inventor： Chi-Yuan Shih , Yu-Chong Tai , Jun Xie , Darron K. Young , Po-Jui Chen
CPC classification number: B01D15/22 , G01N30/02 , G01N30/461 , G01N30/466 , G01N30/6095 , G01N30/78 , G01N30/96 , G01N2030/524 , Y10T29/49826 , B01D15/363 , B01D15/3804 , B01D15/362 , B01D15/34 , B01D15/325 , B01D15/361
Abstract: Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process.
Abstract translation: 使用集成色谱系统和设备实时监测分析物的系统和方法。 集成的微流体液相色谱装置和系统包括集成到单个底物中的多个分离柱。 使用这样的器件，可以同时执行多个样本的并行分析和/或可以在单个芯片或衬底上同时执行单个样本的顺序分析。 该装置和系统非常适用于高压液相色谱（HPLC）应用。 包括嵌入式聚对二甲苯通道的HPLC芯片和器件可以使用单一掩模工艺制造。
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公开(公告)号：US20190092732A1
公开(公告)日：2019-03-28
申请号：US16206611
申请日：2018-11-30
Applicant: City of Hope , California Institute of Technology
Inventor： Binghui Shen , Judith Campbell , Li Zheng , Hongzhi Li , David Horne , Jun Xie , Kenneth Karanja
IPC: C07D215/56 , A61K45/06 , A61K31/47
CPC classification number: C07D215/56 , A61K31/47 , A61K45/06
Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
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公开(公告)号：US20170226063A1
公开(公告)日：2017-08-10
申请号：US15428021
申请日：2017-02-08
Applicant: City of Hope , California Institute of Technology
Inventor： Binghui Shen , Judith Campbell , Li Zheng , Hongzhi Li , David Horne , Jun Xie , Kenneth Karanja
IPC: C07D215/56 , A61K31/47 , A61K45/06
CPC classification number: C07D215/56 , A61K31/47 , A61K45/06
Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
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9.发明申请公开(公告)号：US20140048481A1
公开(公告)日：2014-02-20
申请号：US14065210
申请日：2013-10-28
Applicant: California Institute of Technology
Inventor： Chi-Yuan Shih , Yu-Chong Tai , Jun Xie , Darron K. Young , Po-Jui Chen
IPC: B01D15/22
CPC classification number: B01D15/22 , G01N30/02 , G01N30/461 , G01N30/466 , G01N30/6095 , G01N30/78 , G01N30/96 , G01N2030/524 , Y10T29/49826 , B01D15/363 , B01D15/3804 , B01D15/362 , B01D15/34 , B01D15/325 , B01D15/361
Abstract: Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process.
Abstract translation: 使用集成色谱系统和设备实时监测分析物的系统和方法。 集成的微流体液相色谱装置和系统包括集成到单个底物中的多个分离柱。 使用这样的器件，可以同时执行多个样本的并行分析和/或可以在单个芯片或衬底上同时执行单个样本的顺序分析。 该装置和系统非常适用于高压液相色谱（HPLC）应用。 包括嵌入式聚对二甲苯通道的HPLC芯片和器件可以使用单一掩模工艺制造。
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10.发明申请IC-PROCESSED POLYMER NANO-LIQUID CHROMATOGRAPHY SYSTEM ON-A-CHIP AND METHOD OF MAKING IT 有权IC处理聚合物纳米液相色谱系统及其制备方法公开(公告)号：US20130140270A1
公开(公告)日：2013-06-06
申请号：US13680030
申请日：2012-11-17
Inventor： Yu-Chong Tai , Qing He , Jun Xie , Changlin Pang , Terry D. Lee , Damien Rodger , Matthieu Liger
IPC: H05K3/28
CPC classification number: H05K3/284 , G01N30/6047 , G01N30/6095 , G01N2030/645 , G03F1/80 , G01N2030/625
Abstract: Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.
Abstract translation: 根据本发明的实施方案涉及集成在片上的填充柱纳米液相色谱（nano-LC）系统及其制造和使用方法。 微制造的芯片包括以常规用于形成集成电路的方法兼容的工艺制造的柱，过滤器，注射器和检测器。 该柱可以填充有用于各种不同固定相的载体，以允许不同形式的纳米LC的性能，包括但不限于反相，正相，吸附，尺寸排阻，亲和力和离子色谱。 交叉通道注射器在柱入口处注入纳升/皮升体积的样品塞。 集成在色谱柱出口处的电化学/电导率传感器测量分离信号。 自对准的通道加强技术提高了微流体系统的压力等级，使其能够承受通常用于高效液相色谱（HPLC）的高压。 使用离子交换纳米LC成功地证明了在水中阴离子的混合物的片上样品注入，分离和检测。
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