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    LOCALIZED RELEASE OF SYSTEMICALLY CIRCULATING THERAPEUTIC SUBSTANCES
    1.
    发明申请
    LOCALIZED RELEASE OF SYSTEMICALLY CIRCULATING THERAPEUTIC SUBSTANCES 有权

    公开(公告)号：US20220362380A1

    公开(公告)日：2022-11-17

    申请号：US17294521

    申请日：2020-11-10

    Applicant: Cochlear Limited

    Inventor： Jonathon Kirk ,  Daniel Smyth ,  Ya Lang Enke ,  Wolfram Frederik Dueck

    IPC: A61K41/00 ,  A61K9/127 ,  A61K9/00 ,  A61N1/05

    Abstract: Presented herein are techniques for localized release of systemically circulating therapeutic substances, which combine many of the advantages of systematic and localized administration, while eliminating many of the associated drawbacks. More specifically, in accordance with the techniques presented herein, an electro-responsive biomaterial is systemically administered to a recipient of an electrically-stimulating implantable medical device. The electro-responsive biomaterial comprises a therapeutic substance that is only activated (e.g., released) in the presence of an electromagnetic field generated by the electrically-stimulating implantable medical device.

    Heating elements for thermally-driven phase transition implantable micropump
    2.
    发明授权
    Heating elements for thermally-driven phase transition implantable micropump 有权

    公开(公告)号：US12290660B2

    公开(公告)日：2025-05-06

    申请号：US17274760

    申请日：2019-12-31

    Applicant: Cochlear Limited

    Inventor： Wolfram Frederik Dueck ,  Daniel Smyth ,  Jonathon Kirk

    IPC: A61M5/142 ,  A61F2/18 ,  A61M5/168

    Abstract: An apparatus includes an enclosure containing a hermetically sealed region, the enclosure configured to be implanted on or within a recipient. The apparatus further includes circuitry within the hermetically sealed region and configured to generate signals. The apparatus further includes at least one heating element configured to receive the signals and to generate heat in response to the signals. The apparatus further includes at least one flow control element outside the hermetically sealed region and configured to respond to the heat by controlling a flow of liquid through at least one cannula to controllably administer the liquid internally to the recipient.

    ESTIMATION OF ELECTROPORATION PARAMETER LEVELS
    3.
    发明公开
    ESTIMATION OF ELECTROPORATION PARAMETER LEVELS 审中-公开

    公开(公告)号：US20230398349A1

    公开(公告)日：2023-12-14

    申请号：US18250340

    申请日：2021-10-15

    Applicant: Cochlear Limited

    Inventor： Paul Michael Carter ,  Daniel Smyth ,  Wolfram Frederik Dueck ,  Stefan Jozef Mauger

    IPC: A61N1/32 ,  A61N1/36 ,  A61N1/05 ,  A61B5/0536 ,  A61B5/388 ,  A61B5/00

    CPC classification number: A61N1/327 ,  A61N1/36038 ,  A61N1/0541 ,  A61B5/0536 ,  A61B5/388 ,  A61B5/686 ,  A61B5/0071

    Abstract: A method includes receiving information regarding a position and/or an orientation of an implantable device relative to a body portion of a recipient during and/or after implantation of at least a portion of the device on and/or into the body portion. The device includes a plurality of electrodes configured to apply electroporation to first cells of the body portion while not damaging second cells of the body portion. The method includes estimating, in response at least in part to the information, first interactions of the electrodes with respect to the first cells. The method further includes estimating, in response at least in part to the information, second interactions of the electrodes with respect to the second cells. The method further includes generating, in response at least in part to the estimated first interactions and the estimated second interactions, values of electrical parameters configured to be provided to the plurality of electrodes to electroporate to the first cells while not damaging the second cells.

    Cochlear implant stimulation
    5.
    发明授权
    Cochlear implant stimulation 有权
    人工耳蜗刺激

    公开(公告)号：US09440073B2

    公开(公告)日：2016-09-13

    申请号：US14799764

    申请日：2015-07-15

    Applicant: Cochlear Limited

    Inventor： Wolfram Frederik Dueck ,  Nicholas Charles Kendall Pawsey ,  Peter Raymond Sibary ,  Claudia Tasche

    IPC: A61N1/00 ,  A61N1/36 ,  A61N1/05

    CPC classification number: A61N1/36032 ,  A61N1/0541 ,  A61N1/36036

    Abstract: Presented herein are trans-modiolar stimulation techniques in which stimulation current is sourced (delivered) by at least one intra-cochlear stimulating contact and is sunk at a group of other intra-cochlear stimulating contacts. The group of other intra-cochlear stimulating contacts is positioned (located) across a section of the recipient's modiolus from the intra-cochlear stimulating contact that sources the stimulation. As such, stimulation current generally passes through the modiolus to stimulate spiral ganglion cells and evoke a hearing percept.

    Abstract translation: 这里提出的是反式模式刺激技术，其中通过至少一个耳蜗内刺激接触来源（递送）刺激电流并且沉没在一组其他耳蜗内刺激接触处。 其他耳蜗内刺激接触的组被定位（定位）穿过来自刺激的耳蜗内刺激接触的接受者的一部分。 因此，刺激电流通常通过脉络膜刺激螺旋神经节细胞并引起听觉感知。

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