公开(公告)号：US20240041787A1

公开(公告)日：2024-02-08

申请号：US18256298

申请日：2022-09-26

Applicant: DALIAN UNIVERSITY OF TECHNOLOGY

Inventor： Wen SUN ,  Dongmei XI ,  Xiaojun PENG ,  Jiangli FAN

IPC: A61K9/51 ,  A61K41/00 ,  C07F5/02 ,  A61K9/00 ,  A61P35/00

CPC classification number: A61K9/5146 ,  A61K41/0057 ,  C07F5/022 ,  A61K9/0019 ,  A61P35/00

Abstract: A photosensitizer molecule increases the retention time thereof in a tumor and the enhancement of the therapy for large-volume tumors. AN-BDP is synthesized by means of introducing anthracene into BODIPY-meso, and due to the strong intermolecular π-π interaction of anthracene, AN-BDP and an amphiphilic block copolymer DSPE-PEG2000 are self-assembled into stable nanoparticles AN-BDP NPs. By means of anthracene, AN-BDP can be excited to a triplet excited state under light irradiation and acts with O2 to generate 1O2. AN-BDP NPs are enriched at the tumor site and retained for about 10 days after tail vein injection. In a mouse tumor model having a conventional volume tumor, AN-BDP NPs can completely inhibit the growth of the tumor by means of one-time tail vein injection and one-time photoirradiation therapy.