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Patent Agency Ranking
1.发明公开公开(公告)号：US20240041787A1
公开(公告)日：2024-02-08
申请号：US18256298
申请日：2022-09-26
Applicant: DALIAN UNIVERSITY OF TECHNOLOGY
Inventor： Wen SUN , Dongmei XI , Xiaojun PENG , Jiangli FAN
CPC classification number: A61K9/5146 , A61K41/0057 , C07F5/022 , A61K9/0019 , A61P35/00
Abstract: A photosensitizer molecule increases the retention time thereof in a tumor and the enhancement of the therapy for large-volume tumors. AN-BDP is synthesized by means of introducing anthracene into BODIPY-meso, and due to the strong intermolecular π-π interaction of anthracene, AN-BDP and an amphiphilic block copolymer DSPE-PEG2000 are self-assembled into stable nanoparticles AN-BDP NPs. By means of anthracene, AN-BDP can be excited to a triplet excited state under light irradiation and acts with O2 to generate 1O2. AN-BDP NPs are enriched at the tumor site and retained for about 10 days after tail vein injection. In a mouse tumor model having a conventional volume tumor, AN-BDP NPs can completely inhibit the growth of the tumor by means of one-time tail vein injection and one-time photoirradiation therapy.
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2.发明公开公开(公告)号：US20230280336A1
公开(公告)日：2023-09-07
申请号：US18196618
申请日：2023-05-12
Inventor： Jiangli FAN , Gengwen CHEN , Tianping XIA , Yi YE , Ziqian ZHANG , Qichao YAO
CPC classification number: G01N33/5094 , G01N33/582 , C09B69/00
Abstract: Disclosed are a leukocyte classification reagent and kit, a classification method, an erythrocyte classification reagent and kit, and an analysis method. Both the leukocyte classification reagent and the erythrocyte classification reagent comprise a fluorescent dye represented by the general formula F. The dye can stain the nucleic acids of leukocytes and erythrocytes, therefore, during blood analysis, the classification and/or counting of leukocytes in a sample can be accurately realized, and the classification and/or counting of erythrocytes in a sample can be accurately realized, in particular the identification and/or counting of RETs. In addition, the types of dyes used in blood cell analysis may also be simplified.
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公开(公告)号：US20210030873A1
公开(公告)日：2021-02-04
申请号：US16633087
申请日：2017-11-24
Inventor： Xiaojun PENG , Mingle LI , Jiangli FAN , Qichao YAO , Jianjun DU , Saran LONG , Jingyun WANG
IPC: A61K41/00
Abstract: A photosensitizer and derivative, application thereof. The photosensitizer has the structure of general formula I, wherein X is S or Se, Y is organic or inorganic ion, R1 and R2 are independently selected from H, alkyl, alkoxy, alkyl amido, alkyl azide and the like; R3 is selected from H, alkyl, alkoxy, amino sulfonyl, hydroxyl, carboxyl and the like, and L1 is a linker selected from —(CH2)n1— or —(CH2CH2O)n2—. The derivatives are molecular medicines with drug molecules of anticancer and chemotherapy or tumor targeting function connected to the said photosensitizer. The photosensitizer has excellent near infrared characteristics and low dark toxicity and is used in the field of photodynamic tumor therapy. The introduction of benzophenothiazine or benzophenoselenazine into derivatives with tumor-targeting function could improve the specific uptake of photosensitizer in tumor tissues. Moreover, clinical anticancer drugs can be introduced into the structure of benzophenothiazine or benzophenoselenazine to achieve the purpose of combining therapy of photodynamic therapy and chemotherapy.
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公开(公告)号：US20210188875A1
公开(公告)日：2021-06-24
申请号：US17053042
申请日：2019-04-22
Inventor： Jiangli FAN , Qichao YAO , Haidong LI , Yana BIAN , Mingle LI , Jingyun WANG , Xiaojun PENG
IPC: C07D517/16 , C07D513/16 , A61P35/00 , A61K41/00 , A61K9/14 , C09K11/06 , G01N21/64
Abstract: Disclosed are an oxazine compound and an application thereof. The oxazine compound has a structure of a general formula F. The oxazine compound described in the disclosure is a photo/acoustic dynamic active organic molecule with near-infrared absorption-emission function as well as photosensitivity and acoustic sensitivity. Maximum absorption and emission wavelengths of the compound are both greater than 660 nanometers, and a triplet-state conversion rate of the compound is high; and under illumination or ultrasound, the compound can produce reactive oxygen species with high efficiency, which has a good killing effect on cancer cells and cancer tissues, and almost has no toxic or side effects on normal tissues while achieving photo/acoustic dynamic therapy on tumors.
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5.发明申请BORON-DIPYRROMETHENE FLUORESCENCE PROBES AND MANUFACTURING METHOD AND USE THEREOF 有权硼 - 二氯乙烯荧光探针及其制造方法及其应用公开(公告)号：US20170029444A1
公开(公告)日：2017-02-02
申请号：US15039674
申请日：2014-11-26
Applicant: DALIAN UNIVERSITY OF TECHNOLOGY
Inventor： Jiangli FAN , Hao ZHU , Xiaojun PENG , Jingyun WANG
CPC classification number: C07F5/022 , C07F5/02 , C09K11/06 , C09K2211/1022 , C09K2211/1029 , G01N33/582 , G01N33/84
Abstract: The present invention provides a difluoroboron dipyrromethene fluorescent probe having a structure represented by the following general formula I, and a production method and an application thereof. Said difluoroboron dipyrromethene fluorescent probe exhibits low background fluorescence, and a rapid and significant fluorescence enhancement up to 100 times after the addition of hypochloric acid. The fluorescent intensity of said fluorescent probe shows a good linear relation with the concentration of hypochloric acid in a nanomole level, and the detection limit thereof is 0.56 nanomole. Said fluorescent probe has good selectivity since it hardly responds to other reactive oxygen species such as H2O2, O2−, TBHP, HO., TBO., 1O2 and NO., and is not interfered by pH in a wide range. Said fluorescent probe can be applied to detect hypochloric acid in living cells.
Abstract translation: 本发明提供具有由以下通式I表示的结构的二氟硼烷二吡咯亚甲基荧光探针及其制备方法和应用。 所述二氟硼酸二吡咯亚甲基荧光探针显示低背景荧光，并且在加入次氯酸之后快速且显着的荧光增强达100倍。 所述荧光探针的荧光强度与纳摩尔浓度的次氯酸浓度呈良好的线性关系，其检出限为0.56纳摩尔。 所述荧光探针具有良好的选择性，因为它几乎不响应其它活性氧物质如H 2 O 2，O 2 - ，TBHP，HO·，TBO·，1 O 2和NO-，并且不受宽泛的pH的干扰 范围。 所述荧光探针可用于检测活细胞中的次氯酸。
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