公开(公告)号：US20160122368A1

公开(公告)日：2016-05-05

申请号：US14526996

申请日：2014-10-29

Applicant: DIONEX CORPORATION ,  THERMO ELECTRON MANUFACTURING LIMITED

Inventor： Xiaodong LIU ,  Richard T. WILLIAMS ,  Xiao CUI

IPC: C07F7/08 ,  C07B63/00

CPC classification number: C07F7/0838 ,  B01D15/305 ,  B01D15/325 ,  B01D15/364 ,  B01D15/3847 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3246 ,  B01J20/3259 ,  B01J20/3285 ,  C07B63/00 ,  C07F7/0876

Abstract: A chromatographic material comprising a zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II: wherein R1, R2, R3 are independently selected from an oxygen atom that is configured to connect to a substrate atom in the substrate, an oxygen atom that is configured to connect to a silicon atom of an adjacent ligand, a hydroxyl group, a halogen atom, an alkoxy group, a dialkylamino group, an acyl group, an alkyl group, or an aryl group; L1, L2 and L3 are independently hydrophobic moieties; each containing 2 to 30 carbon atoms, wherein there are at least 10 carbon atoms in the combined chain lengths of L1, L2 and L3; X is an O atom, S atom, amide group or sulfonamide group; n is 0 or 1; R4, R5 are independently selected from a hydrogen atom or a hydrocarbon moiety containing 1 to 20 carbon atoms; and Rf is a negatively charged moiety comprising a sulfonic, carboxylic, or phosphonic functional group.

Abstract translation: 一种色谱材料，其包含与底物共价结合的两性离子配体，所述配体优选具有式II：其中R 1，R 2，R 3独立地选自被配置为连接到底物中的底物原子的氧原子，氧原子 其被配置为连接到相邻配体，羟基，卤素原子，烷氧基，二烷基氨基，酰基，烷基或芳基的硅原子; L1，L2和L3独立地是疏水部分; 每个含有2至30个碳原子，其中在L1，L2和L3的组合链长度中存在至少10个碳原子; X是O原子，S原子，酰胺基或磺酰胺基; n为0或1; R 4，R 5独立地选自氢原子或含有1至20个碳原子的烃部分; 并且Rf是包含磺酸，羧酸或膦酸官能团的带负电荷的部分。

公开(公告)号：US20210213420A1

公开(公告)日：2021-07-15

申请号：US17146447

申请日：2021-01-11

Applicant: DIONEX CORPORATION

Inventor： Xiaodong LIU ,  Xiao CUI ,  Xuefei SUN

IPC: B01J20/287 ,  B01J20/32 ,  B01D15/32 ,  B01D15/20 ,  B01J20/289 ,  B01J20/30 ,  C07D493/04 ,  C07H1/06 ,  C07H15/224 ,  C07H15/23 ,  C07H15/232 ,  C07H15/234 ,  C07H15/238 ,  C08G77/392

Abstract: A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group. Preferred conditions of reacting the polymer with the substrate include elevated temperature and reduced pressure.

公开(公告)号：US20180008959A1

公开(公告)日：2018-01-11

申请号：US15543809

申请日：2016-01-12

Applicant: DIONEX CORPORATION

Inventor： Xiaodong LIU ,  Xiao CUI ,  Xuefei SUN

IPC: B01J20/287 ,  B01D15/20 ,  C07H15/234 ,  C07H15/232 ,  C07H15/23 ,  B01J20/32 ,  C07H1/06 ,  C07D493/04 ,  C07H15/238 ,  B01D15/32 ,  B01J20/289 ,  B01J20/30 ,  C08G77/392 ,  C07H15/224

CPC classification number: B01J20/287 ,  B01D15/20 ,  B01D15/325 ,  B01J20/289 ,  B01J20/3078 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3272 ,  B01J20/328 ,  B01J2220/44 ,  B01J2220/52 ,  B01J2220/54 ,  B01J2220/58 ,  C07D493/04 ,  C07H1/06 ,  C07H15/224 ,  C07H15/23 ,  C07H15/232 ,  C07H15/234 ,  C07H15/238 ,  C08G77/392

Abstract: A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group. Preferred conditions of reacting the polymer with the substrate include elevated temperature and reduced pressure.