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公开(公告)号：US20160139014A1
公开(公告)日：2016-05-19
申请号：US15006441
申请日：2016-01-26
Applicant: DIONEX CORPORATION
Inventor： Xiaodong LIU , Christopher A. POHL
IPC: G01N1/40
CPC classification number: G01N1/405 , B01J20/286 , B01J20/287 , B01J20/289 , B01J20/3219 , B01J20/3246 , B01J20/3257 , B01J2220/54 , C07F7/21
Abstract: Ligand compositions and stationary phases comprising polyhedral oligomeric silsesquioxane moieties are incorporated in to chromatographic stationary phases, and these phases are incorporated into chromatography devices, such as columns. The compositions and devices are of use to separate molecular mixtures.
Abstract translation: 将配体组合物和包含多面体低聚倍半硅氧烷部分的固定相并入到色谱固定相中，并将这些相结合到诸如柱的色谱装置中。 组合物和装置用于分离分子混合物。
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公开(公告)号：US20150224473A1
公开(公告)日：2015-08-13
申请号：US14175689
申请日：2014-02-07
Applicant: THERMO ELECTRON MANUFACTURING LIMITED , DIONEX CORPORATION
Inventor： Kevin SKINLEY , Xiaodong LIU , Christopher A. POHL , Harald RITCHIE
IPC: B01J20/283 , B01J20/22 , B01J20/30 , B01J20/28 , B01J20/10
CPC classification number: B01J20/283 , B01J20/103 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28019 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/287 , B01J20/3071 , B01J20/3078 , B01J20/3085 , B01J2220/42 , B01J2220/44
Abstract: A particulate material for chromatographic use comprising silica particles is provided having a skeleton structure containing silsesquioxane cage moieties. The material is useful as a chromatographic material, for example in HPLC. The silica particles may be hybrid organo-silica particles wherein the silsesquioxane moieties comprise a cage structure having silicon atoms positioned at corners of the cage wherein one or more silicon atoms positioned at the corners of the cage carry an organic group. A preferred method of preparing the particulate material comprises hydrolysing a silsesquioxane as a co-component of a hydrolysis mixture, especially in a Stöber or modified Stöber process.
Abstract translation: 提供了包含二氧化硅颗粒的用于色谱用途的颗粒材料，其具有含有倍半硅氧烷笼部分的骨架结构。 该材料可用作色谱材料，例如在HPLC中。 二氧化硅颗粒可以是杂化有机二氧化硅颗粒，其中倍半硅氧烷部分包含具有位于笼的拐角处的硅原子的笼状结构，其中位于笼的拐角处的一个或多个硅原子携带有机基团。 制备颗粒材料的优选方法包括水解作为水解混合物的共组分的倍半硅氧烷，特别是在Stöber或改性Stöber方法中。
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3.发明申请公开(公告)号：US20180017534A1
公开(公告)日：2018-01-18
申请号：US15649220
申请日：2017-07-13
Applicant: THERMO HYPERSIL-KEYSTONE LLC , DIONEX CORPORATION
Inventor： Brandon Howard ROBSON , Xuefei SUN , Xiaodong LIU
CPC classification number: G01N30/7266 , H01J49/0431 , H01J49/167
Abstract: An electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed. An emitter capillary includes an inlet end and an outlet end. A fitting is coupled to the inlet end of the emitter, configured to be removably connected to the separation column. A stop with a defined through hole is integrated proximate the inlet end of the emitter to produce a path for liquid to flow from the separation column to the emitter via the through hole where a voltage is applied to the liquid entering the emitter.
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4.发明申请公开(公告)号：US20170097326A1
公开(公告)日：2017-04-06
申请号：US14872139
申请日：2015-10-01
Applicant: DIONEX CORPORATION , THERMO HYPERSIL-KEYSTONE LLC
Inventor： Xiaodong LIU , Jennifer M. NGUYEN , Ronald A. SHERANT , Mark L. TRACY
IPC: G01N30/56
CPC classification number: G01N30/56 , B01D15/206 , G01N2030/027 , G01N2030/565
Abstract: A method of packing a chromatography column, including: dispersing chromatographic media particles in a slurry solution to form a slurry, filling a chromatography column with the chromatographic media particles by introducing the slurry to the column and applying a pressure to pack the chromatographic media particles in the chromatography column. The slurry solution is preferably aqueous based slurry solution. The pressure is preferably applied and held substantially constant for a first period at a first pressure and is applied and held substantially constant for a second period, following the first period, at a second pressure higher than the first pressure.
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公开(公告)号：US20160122368A1
公开(公告)日：2016-05-05
申请号：US14526996
申请日：2014-10-29
Applicant: DIONEX CORPORATION , THERMO ELECTRON MANUFACTURING LIMITED
Inventor： Xiaodong LIU , Richard T. WILLIAMS , Xiao CUI
CPC classification number: C07F7/0838 , B01D15/305 , B01D15/325 , B01D15/364 , B01D15/3847 , B01J20/286 , B01J20/289 , B01J20/3204 , B01J20/3246 , B01J20/3259 , B01J20/3285 , C07B63/00 , C07F7/0876
Abstract: A chromatographic material comprising a zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II: wherein R1, R2, R3 are independently selected from an oxygen atom that is configured to connect to a substrate atom in the substrate, an oxygen atom that is configured to connect to a silicon atom of an adjacent ligand, a hydroxyl group, a halogen atom, an alkoxy group, a dialkylamino group, an acyl group, an alkyl group, or an aryl group; L1, L2 and L3 are independently hydrophobic moieties; each containing 2 to 30 carbon atoms, wherein there are at least 10 carbon atoms in the combined chain lengths of L1, L2 and L3; X is an O atom, S atom, amide group or sulfonamide group; n is 0 or 1; R4, R5 are independently selected from a hydrogen atom or a hydrocarbon moiety containing 1 to 20 carbon atoms; and Rf is a negatively charged moiety comprising a sulfonic, carboxylic, or phosphonic functional group.
Abstract translation: 一种色谱材料，其包含与底物共价结合的两性离子配体，所述配体优选具有式II：其中R 1，R 2，R 3独立地选自被配置为连接到底物中的底物原子的氧原子，氧原子 其被配置为连接到相邻配体，羟基，卤素原子，烷氧基，二烷基氨基，酰基，烷基或芳基的硅原子; L1，L2和L3独立地是疏水部分; 每个含有2至30个碳原子，其中在L1，L2和L3的组合链长度中存在至少10个碳原子; X是O原子，S原子，酰胺基或磺酰胺基; n为0或1; R 4，R 5独立地选自氢原子或含有1至20个碳原子的烃部分; 并且Rf是包含磺酸，羧酸或膦酸官能团的带负电荷的部分。
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Patent Agency Ranking
公开(公告)号：US20210356444A1
公开(公告)日：2021-11-18
申请号：US17328068
申请日：2021-05-24
Applicant: THERMO HYPERSIL-KEYSTONE LLC , DIONEX CORPORATION
Inventor： Brandon Howard ROBSON , Xuefei SUN , Xiaodong LIU
Abstract: An electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed. An emitter capillary includes an inlet end and an outlet end. A fitting is coupled to the inlet end of the emitter, configured to be removably connected to the separation column. A stop with a defined through hole is integrated proximate the inlet end of the emitter to produce a path for liquid to flow from the separation column to the emitter via the through hole where a voltage is applied to the liquid entering the emitter.
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公开(公告)号：US20190049352A1
公开(公告)日：2019-02-14
申请号：US16160925
申请日：2018-10-15
Applicant: DIONEX CORPORATION
Inventor： Xiaodong LIU , Christopher A. POHL
IPC: G01N1/40 , C07F7/21 , B01J20/32 , B01J20/286 , B01J20/289 , B01J20/287
Abstract: Ligand compositions and stationary phases comprising polyhedral oligomeric silsesquioxane moieties are incorporated in to chromatographic stationary phases, and these phases are incorporated into chromatography devices, such as columns. The compositions and devices are of use to separate molecular mixtures.
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8.发明公开公开(公告)号：US20240044853A1
公开(公告)日：2024-02-08
申请号：US18450837
申请日：2023-08-16
Applicant: THERMO HYPERSIL-KEYSTONE LLC , DIONEX CORPORATION
Inventor： Brandon Howard ROBSON , Xuefei SUN , Xiaodong LIU
CPC classification number: G01N30/7266 , H01J49/0431 , H01J49/167
Abstract: An electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed. An emitter capillary includes an inlet end and an outlet end. A fitting is coupled to the inlet end of the emitter, configured to be removably connected to the separation column. A stop with a defined through hole is integrated proximate the inlet end of the emitter to produce a path for liquid to flow from the separation column to the emitter via the through hole where a voltage is applied to the liquid entering the emitter.
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公开(公告)号：US20210213420A1
公开(公告)日：2021-07-15
申请号：US17146447
申请日：2021-01-11
Applicant: DIONEX CORPORATION
Inventor： Xiaodong LIU , Xiao CUI , Xuefei SUN
IPC: B01J20/287 , B01J20/32 , B01D15/32 , B01D15/20 , B01J20/289 , B01J20/30 , C07D493/04 , C07H1/06 , C07H15/224 , C07H15/23 , C07H15/232 , C07H15/234 , C07H15/238 , C08G77/392
Abstract: A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group. Preferred conditions of reacting the polymer with the substrate include elevated temperature and reduced pressure.
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10.发明申请公开(公告)号：US20180008959A1
公开(公告)日：2018-01-11
申请号：US15543809
申请日：2016-01-12
Applicant: DIONEX CORPORATION
Inventor： Xiaodong LIU , Xiao CUI , Xuefei SUN
IPC: B01J20/287 , B01D15/20 , C07H15/234 , C07H15/232 , C07H15/23 , B01J20/32 , C07H1/06 , C07D493/04 , C07H15/238 , B01D15/32 , B01J20/289 , B01J20/30 , C08G77/392 , C07H15/224
CPC classification number: B01J20/287 , B01D15/20 , B01D15/325 , B01J20/289 , B01J20/3078 , B01J20/3092 , B01J20/3204 , B01J20/3217 , B01J20/3272 , B01J20/328 , B01J2220/44 , B01J2220/52 , B01J2220/54 , B01J2220/58 , C07D493/04 , C07H1/06 , C07H15/224 , C07H15/23 , C07H15/232 , C07H15/234 , C07H15/238 , C08G77/392
Abstract: A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group. Preferred conditions of reacting the polymer with the substrate include elevated temperature and reduced pressure.
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