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公开(公告)号：US09179693B2
公开(公告)日：2015-11-10
申请号：US13827730
申请日：2013-03-14
Applicant: DuPont Nutrition Biosciences ApS
Inventor： Luis Romero , Peter Plumstead , Luke Barnard
CPC classification number: A61K38/465 , A23K10/18 , A23K20/174 , A23K20/189 , A23K20/20 , A23K40/20 , A23K40/25 , A23K50/30 , A23K50/75 , A61K35/66 , A61K35/742 , A61K38/46 , C12Y301/03 , C12Y301/03008 , C12Y301/03026
Abstract: A method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving dietary phosphorus absorption and retention, or for improving the efficacy of the phytase, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (FCR) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g. improving) the immune response of the subject or for reducing populations of pathogenic bacteria in the gastrointestinal tract of a subject, or for reducing nutrient excretion in manure, which method comprising administering to a subject at least one direct fed microbial in combination with a phytase, wherein the phytase is administered to the subject at a dosage of more than about 1500 FTU/kg feed.
Abstract translation: 用于改善受试者的性能或改善饲料中原料的消化率（例如营养物消化率，例如氨基酸消化率）或用于改善氮保留或改善膳食磷吸收和保留的方法或用于改善 植酸酶的功效，或用于改善受试者对坏死性肠炎的抵抗力或改善饲料转化率（FCR）或改善受试者体重增加或改善受试者的饲料效率或调节（例如改善）免疫应答 或用于减少受试者的胃肠道中的致病细菌群体，或用于减少粪便中的营养物排泄，该方法包括向受试者施用至少一种直接进食的微生物与植酸酶的组合，其中施用植酸酶 以超过约1500FTU / kg饲料的剂量给予受试者。
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公开(公告)号：US10149891B2
公开(公告)日：2018-12-11
申请号：US14866533
申请日：2015-09-25
Applicant: DuPont Nutrition Biosciences ApS
Inventor： Luis Romero , Peter Plumstead , Luke Barnard
IPC: A61K38/46 , A61K35/742 , A23K40/25 , A23K40/20 , A61K35/66 , A23K10/18 , A23K20/174 , A23K20/189 , A23K20/20 , A23K50/75 , A23K50/30
Abstract: A method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving dietary phosphorus absorption and retention, or for improving the efficacy of the phytase, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (FCR) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g. improving) the immune response of the subject or for reducing populations of pathogenic bacteria in the gastrointestinal tract of a subject, or for reducing nutrient excretion in manure, which method comprising administering to a subject at least one direct fed microbial in combination with a phytase, wherein the phytase is administered to the subject at a dosage of more than about 1500 FTU/kg feed.
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Patent Agency Ranking
公开(公告)号：US11235035B2
公开(公告)日：2022-02-01
申请号：US16208829
申请日：2018-12-04
Applicant: DUPONT NUTRITION BIOSCIENCES APS
Inventor： Luis Romero , Peter Plumstead , Luke Barnard
IPC: A61K38/46 , A61K35/742 , A23K40/25 , A23K40/20 , A23K10/18 , A23K20/174 , A23K20/189 , A23K20/20 , A23K50/75 , A23K50/30 , A61K35/66
Abstract: A method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving dietary phosphorus absorption and retention, or for improving the efficacy of the phytase, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (FCR) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g. improving) the immune response of the subject or for reducing populations of pathogenic bacteria in the gastrointestinal tract of a subject, or for reducing nutrient excretion in manure, which method comprising administering to a subject at least one direct fed microbial in combination with a phytase, wherein the phytase is administered to the subject at a dosage of more than about 1500 FTU/kg feed.
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公开(公告)号：US20140037582A1
公开(公告)日：2014-02-06
申请号：US13827730
申请日：2013-03-14
Applicant: DuPont Nutrition Biosciences ApS
Inventor： Luis Romero , Peter Plumstead , Luke Barnard
CPC classification number: A61K38/465 , A23K10/18 , A23K20/174 , A23K20/189 , A23K20/20 , A23K40/20 , A23K40/25 , A23K50/30 , A23K50/75 , A61K35/66 , A61K35/742 , A61K38/46 , C12Y301/03 , C12Y301/03008 , C12Y301/03026
Abstract: A method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving dietary phosphorus absorption and retention, or for improving the efficacy of the phytase, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (FCR) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g. improving) the immune response of the subject or for reducing populations of pathogenic bacteria in the gastrointestinal tract of a subject, or for reducing nutrient excretion in manure, which method comprising administering to a subject at least one direct fed microbial in combination with a phytase, wherein the phytase is administered to the subject at a dosage of more than about 1500 FTU/kg feed.
Abstract translation: 用于改善受试者的性能或改善饲料中原料的消化率（例如营养物消化率，例如氨基酸消化率）或用于改善氮保留或改善膳食磷吸收和保留的方法或用于改善 植酸酶的功效，或用于改善受试者对坏死性肠炎的抵抗力或改善饲料转化率（FCR）或改善受试者体重增加或改善受试者的饲料效率或调节（例如改善）免疫应答 或用于减少受试者的胃肠道中的致病细菌群体，或用于减少粪便中的营养物排泄，该方法包括向受试者施用至少一种直接进食的微生物与植酸酶的组合，其中施用植酸酶 以超过约1500FTU / kg饲料的剂量给予受试者。
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公开(公告)号：US20190167769A1
公开(公告)日：2019-06-06
申请号：US16208829
申请日：2018-12-04
Applicant: DUPONT NUTRITION BIOSCIENCES APS
Inventor： Luis Romero , Peter Plumstead , Luke Barnard
IPC: A61K38/46 , A23K40/20 , A23K40/25 , A23K20/20 , A61K35/742 , A23K50/30 , A23K50/75 , A61K35/66 , A23K20/189 , A23K20/174 , A23K10/18
Abstract: A method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving dietary phosphorus absorption and retention, or for improving the efficacy of the phytase, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (FCR) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g. improving) the immune response of the subject or for reducing populations of pathogenic bacteria in the gastrointestinal tract of a subject, or for reducing nutrient excretion in manure, which method comprising administering to a subject at least one direct fed microbial in combination with a phytase, wherein the phytase is administered to the subject at a dosage of more than about 1500 FTU/kg feed.
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公开(公告)号：US20180295858A1
公开(公告)日：2018-10-18
申请号：US15520140
申请日：2015-10-23
Applicant: DUPONT NUTRITION BIOSCIENCES APS
Inventor： Svend Haaning , Karsten Matthias Kragh , Stepan Shipovskov , Andrei Miasnikov , Maria Ma , Luis Fernando Romero Millan , Luke Barnard , Shukun Yu , Ernst Meinjohanns , Steffen Bak , Päivi Nurminen , Heli Putaala
IPC: A23K10/14 , C12N9/48 , A23K20/147 , A23K50/75 , A23K50/30
Abstract: A method of preparing a feed additive composition comprising: (a) admixing at least one proline tolerant tripeptidyl peptidase predominantly having exopeptidase activity wherein said proline tolerant tripeptidyl peptidase is capable of cleaving tri-peptides from the N-terminus of peptides having (i) (A) Proline at P1; and (B) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids at P1; or (ii) (a′) Proline at P1′; and (b′) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids or amines at P1′; and one or more ingredients selected from the group consisting of a salt, polyol including sorbitol and glycerol, wheat or a wheat component, sodium acetate, sodium acetate trihydrate, potassium sorbate Talc, polyvinyl alcohol (PVA), benzoate, sorbiate, 1,3-propane diol, glucose, parabens, sodium chloride, citrate, metabisulfite, formate or a combination thereof; and (b) optionally packaging as well as uses of such proline tolerant tripeptidyl peptidases, feed additive compositions, feed additive kits, feeds or feedstuffs and/or premixes.
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公开(公告)号：US20160213755A1
公开(公告)日：2016-07-28
申请号：US14866533
申请日：2015-09-25
Applicant: DuPont Nutrition Biosciences ApS
Inventor： Luis Romero , Peter Plumstead , Luke Barnard
IPC: A61K38/46 , A23K10/18 , A61K35/742 , A23K20/189
CPC classification number: A61K38/465 , A23K10/18 , A23K20/174 , A23K20/189 , A23K20/20 , A23K40/20 , A23K40/25 , A23K50/30 , A23K50/75 , A61K35/66 , A61K35/742 , A61K38/46 , C12Y301/03 , C12Y301/03008 , C12Y301/03026
Abstract: A method for improving the performance of a subject or for improving digestibility of a raw material in a feed (e.g. nutrient digestibility, such as amino acid digestibility), or for improving nitrogen retention, or for improving dietary phosphorus absorption and retention, or for improving the efficacy of the phytase, or for improving the subject's resistance to necrotic enteritis or for improving feed conversion ratio (FCR) or for improving weight gain in a subject or for improving feed efficiency in a subject or for modulating (e.g. improving) the immune response of the subject or for reducing populations of pathogenic bacteria in the gastrointestinal tract of a subject, or for reducing nutrient excretion in manure, which method comprising administering to a subject at least one direct fed microbial in combination with a phytase, wherein the phytase is administered to the subject at a dosage of more than about 1500 FTU/kg feed.
Abstract translation: 用于改善受试者的性能或改善饲料中原料的消化率（例如营养物消化率，例如氨基酸消化率）或用于改善氮保留或改善膳食磷吸收和保留的方法或用于改善 植酸酶的功效，或用于改善受试者对坏死性肠炎的抵抗力或改善饲料转化率（FCR）或改善受试者体重增加或改善受试者的饲料效率或调节（例如改善）免疫应答 或用于减少受试者的胃肠道中的致病细菌群体，或用于减少粪便中的营养物排泄，该方法包括向受试者施用至少一种直接进食的微生物与植酸酶的组合，其中施用植酸酶 以超过约1500FTU / kg饲料的剂量给予受试者。
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