公开(公告)号：US20210236606A1

公开(公告)日：2021-08-05

申请号：US17172923

申请日：2021-02-10

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Charlotte Horsmans Poulsen ,  Svend Haaning

IPC: A61K38/47 ,  A23K20/189 ,  A23K50/30 ,  A61P31/00

Abstract: Disclosed are methods and compositions using glycoside hydrolases, such as an alpha-L-fucosidases, to prevent and/or treat a pathogenic infection and/or diarrhea in an animal wherein the pathogenic infection is caused by a pathogen capable of binding to an animal intestinal cell wherein said binding of the pathogen is dependent on the presence of a pathogen binding site having at least one glycan structure substituted with at least one alpha-1,2-L-fucose moiety comprising administering to the animal an effective amount of a glycoside hydrolase capable of removing the at least one alpha-1,2-L-fucose moiety from the pathogen binding site.

公开(公告)号：US20210120845A1

公开(公告)日：2021-04-29

申请号：US16074144

申请日：2017-02-21

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Karsten Matthias Kragh ,  Svend Haaning ,  Ernst Meinjohanns ,  Peter Edvard Degn ,  Steffan Yde Bak ,  Thomas Eisele

IPC: A23K20/189 ,  A23K10/14 ,  C12N9/48 ,  A23K20/147 ,  A23L2/66

Abstract: The present invention relates to compositions and methods for the production of a hydrolysate comprising at least one endoprotease and a tripeptidyl peptidase capable of cleaving tripeptides from the N-terminus a peptide and/or proteins having one or more of lysine, arginine or glycine in the P1 position wherein said tripeptidyl peptidase is capable of being used at a temperature between 45° C. and 70° C.

公开(公告)号：US20180295858A1

公开(公告)日：2018-10-18

申请号：US15520140

申请日：2015-10-23

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Svend Haaning ,  Karsten Matthias Kragh ,  Stepan Shipovskov ,  Andrei Miasnikov ,  Maria Ma ,  Luis Fernando Romero Millan ,  Luke Barnard ,  Shukun Yu ,  Ernst Meinjohanns ,  Steffen Bak ,  Päivi Nurminen ,  Heli Putaala

IPC: A23K10/14 ,  C12N9/48 ,  A23K20/147 ,  A23K50/75 ,  A23K50/30

Abstract: A method of preparing a feed additive composition comprising: (a) admixing at least one proline tolerant tripeptidyl peptidase predominantly having exopeptidase activity wherein said proline tolerant tripeptidyl peptidase is capable of cleaving tri-peptides from the N-terminus of peptides having (i) (A) Proline at P1; and (B) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids at P1; or (ii) (a′) Proline at P1′; and (b′) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids or amines at P1′; and one or more ingredients selected from the group consisting of a salt, polyol including sorbitol and glycerol, wheat or a wheat component, sodium acetate, sodium acetate trihydrate, potassium sorbate Talc, polyvinyl alcohol (PVA), benzoate, sorbiate, 1,3-propane diol, glucose, parabens, sodium chloride, citrate, metabisulfite, formate or a combination thereof; and (b) optionally packaging as well as uses of such proline tolerant tripeptidyl peptidases, feed additive compositions, feed additive kits, feeds or feedstuffs and/or premixes.

公开(公告)号：US20240180172A1

公开(公告)日：2024-06-06

申请号：US18285530

申请日：2022-04-06

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Steven D. Doig ,  Ryan Lewis Frisch ,  Svend Haaning ,  Frank Wouter Koopman ,  Karsten Matthias Kragh ,  Lene Kragh ,  Chris Leeflang ,  Sina Pricelius

IPC: A21D8/04 ,  A21D2/18 ,  A23L29/00 ,  A23L29/30 ,  C12N9/26

CPC classification number: A21D8/042 ,  A21D2/186 ,  A23L29/06 ,  A23L29/30 ,  C12N9/2411 ,  C12Y302/01

Abstract: This invention relates to polypeptides, more specifically amylase polypeptides and nucleic acids encoding these, and their uses e.g. as non-maltogenic exoamy lases in producing food or feed products.

公开(公告)号：US10933121B2

公开(公告)日：2021-03-02

申请号：US15755711

申请日：2016-08-30

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Charlotte Horsmans Poulsen ,  Svend Haaning

IPC: A61K38/47 ,  A23K20/189 ,  A23K50/30 ,  A61P31/00

Abstract: Disclosed are methods and compositions using glycoside hydrolases, such as an alpha-L-fucosidases, to prevent and/or treat a pathogenic infection and/or diarrhea in an animal wherein the pathogenic infection is caused by a pathogen capable of binding to an animal intestinal cell wherein said binding of the pathogen is dependent on the presence of a pathogen binding site having at least one glycan structure substituted with at least one alpha-1,2-L-fucose moiety comprising administering to the animal an effective amount of a glycoside hydrolase capable of removing the at least one alpha-1,2-L-fucose moiety from the pathogen binding site.

公开(公告)号：US20230404088A1

公开(公告)日：2023-12-21

申请号：US18026395

申请日：2021-09-21

Applicant: DUPONT NUTRITION BIOSCIENCES APS ,  DANISCO US INC.

Inventor： Jacob Flyvholm Cramer ,  Morgan Louise Gifford ,  Svend Haaning ,  Lene Kragh ,  Vinni Høyer Lillelund ,  Donald E. Ward

IPC: A21D8/04 ,  C12N9/34 ,  C12N9/26

CPC classification number: A21D8/042 ,  C12N9/2428 ,  C12Y302/01001 ,  C12N9/2414 ,  C12Y302/01003

Abstract: This invention relates to polypeptides, more specifically non-maltogenic alpha-amylase and glucoamylase polypeptides, and their uses in providing baked products with enhanced resilience.

公开(公告)号：US20170009220A1

公开(公告)日：2017-01-12

申请号：US15116281

申请日：2015-01-30

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Rikke Hoeegh Lorentsen ,  Susan Arent Lund ,  Svend Haaning ,  Igor Nikolaev ,  Sharief Barends ,  Jan Hendrick A Van Tuijl ,  Bert Koops

IPC: C12N9/24 ,  C12P19/14 ,  C12C7/01 ,  A23K20/189 ,  C12C5/00 ,  A61K38/47 ,  C12P19/04

Abstract: The present invention relates to an isolated polypeptide having xylanase activity, selected from the group consisting of: a) a polypeptide comprising an amino acid sequence having at least 87% identity with SEQ ID NO: 1; b) a polypeptide encoded by a polynucleotide having at least 87% identity with SEQ ID NO:2; or c) a fragment of a polypeptide of a) or b) which fragment has xylanase activity.

Abstract translation: 本发明涉及具有木聚糖酶活性的分离的多肽，其选自：a）包含与SEQ ID NO：1具有至少87％同一性的氨基酸序列的多肽; b）由与SEQ ID NO：2具有至少87％同一性的多核苷酸编码的多肽; 或c）a）或b）的多肽的片段，该片段具有木聚糖酶活性。

公开(公告)号：US20230009832A1

公开(公告)日：2023-01-12

申请号：US17777939

申请日：2020-11-20

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Lilia Maria Babe ,  Trine Christensen ,  Svend Haaning ,  Rie Mejldal ,  Igor Nikolaev ,  Sina Pricelius ,  Jens Frisbaek Sørensen ,  Robin Anton Sorg

IPC: C12N9/16 ,  A61K38/46 ,  A23K10/18 ,  A23K20/189 ,  A23K50/30 ,  A23K50/75 ,  A23K50/10

Abstract: Provided herein, inter alia, are engineered phytase polypeptides and fragments thereof with improved thermotolerance as well as methods for producing and using the same for enhancing animal performance on one or more metrics.

公开(公告)号：US10550375B2

公开(公告)日：2020-02-04

申请号：US15116281

申请日：2015-01-30

Applicant: DuPont Nutrition Biosciences ApS

Inventor： Rikke Hoeegh Lorentsen ,  Susan Arent Lund ,  Svend Haaning ,  Igor Nikolaev ,  Sharief Barends ,  Jan Hendrick A Van Tuijl ,  Bart Koops

IPC: C12N9/24 ,  C12C5/00 ,  C12P19/14 ,  A23K20/189 ,  A61K38/47 ,  C12C7/01 ,  C12P19/04

Abstract: The present invention relates to an isolated polypeptide having xylanase activity, selected from the group consisting of: a) a polypeptide comprising an amino acid sequence having at least 87% identity with SEQ ID NO: 1; b) a polypeptide encoded by a polynucleotide having at least 87% identity with SEQ ID NO:2; or c) a fragment of a polypeptide of a) or b) which fragment has xylanase activity.

公开(公告)号：US20190022193A1

公开(公告)日：2019-01-24

申请号：US15755711

申请日：2016-08-30

Applicant: DUPONT NUTRITION BIOSCIENCES APS

Inventor： Charlotte Horsmans Poulsen ,  Svend Haaning

IPC: A61K38/47 ,  A61P31/00 ,  A23K20/189 ,  A23K50/30

Abstract: Disclosed are methods and compositions using glycoside hydrolases, such as an alpha-L-fucosidases, to prevent and/or treat a pathogenic infection and/or diarrhea in an animal wherein the pathogenic infection is caused by a pathogen capable of binding to an animal intestinal cell wherein said binding of the pathogen is dependent on the presence of a pathogen binding site having at least one glycan structure substituted with at least one alpha-1,2-L-fucose moiety comprising administering to the animal an effective amount of a glycoside hydrolase capable of removing the at least one alpha-1,2-L-fucose moiety from the pathogen binding site.