公开(公告)号：US20240084267A1

公开(公告)日：2024-03-14

申请号：US18271983

申请日：2022-01-12

Applicant: Duke University

Inventor： Nicholas HEATON ,  Heather FROGGATT ,  Kaitlyn BURKE ,  Benjamin CHAMBERS ,  Rebecca LEONARD ,  Ryan CHAPARIAN

IPC: C12N7/00 ,  A61K39/12 ,  C12N15/86

CPC classification number: C12N7/00 ,  A61K39/12 ,  C12N15/86 ,  A61K2039/5256 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16143 ,  C12N2760/16171

Abstract: The present invention provides recombinant viral segments comprising an artificial intron, DNA constructs encoding these viral segments, and recombinant viruses comprising these viral segments. Also provided are methods of making and using the recombinant viruses described herein.