公开(公告)号：US20250144198A1

公开(公告)日：2025-05-08

申请号：US18684346

申请日：2022-08-16

Applicant: Duke University

Inventor： Nicholas HEATON ,  Zhaochen LUO

IPC: A61K39/145 ,  A61P37/04 ,  C07K14/005 ,  C12N15/10 ,  G01N33/68

Abstract: The present invention provides protein libraries comprising variants of an antigenic viral protein that each have a different set of mutations at one or more hypervariable sites. Nucleic acid and vector libraries encoding the protein libraries, vaccines comprising the libraries, and methods of inducing an immune response against the antigenic viral protein are also provided.

公开(公告)号：US20240084267A1

公开(公告)日：2024-03-14

申请号：US18271983

申请日：2022-01-12

Applicant: Duke University

Inventor： Nicholas HEATON ,  Heather FROGGATT ,  Kaitlyn BURKE ,  Benjamin CHAMBERS ,  Rebecca LEONARD ,  Ryan CHAPARIAN

IPC: C12N7/00 ,  A61K39/12 ,  C12N15/86

CPC classification number: C12N7/00 ,  A61K39/12 ,  C12N15/86 ,  A61K2039/5256 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16143 ,  C12N2760/16171

Abstract: The present invention provides recombinant viral segments comprising an artificial intron, DNA constructs encoding these viral segments, and recombinant viruses comprising these viral segments. Also provided are methods of making and using the recombinant viruses described herein.