公开(公告)号：US20250144198A1

公开(公告)日：2025-05-08

申请号：US18684346

申请日：2022-08-16

Applicant: Duke University

Inventor： Nicholas HEATON ,  Zhaochen LUO

IPC: A61K39/145 ,  A61P37/04 ,  C07K14/005 ,  C12N15/10 ,  G01N33/68

Abstract: The present invention provides protein libraries comprising variants of an antigenic viral protein that each have a different set of mutations at one or more hypervariable sites. Nucleic acid and vector libraries encoding the protein libraries, vaccines comprising the libraries, and methods of inducing an immune response against the antigenic viral protein are also provided.

公开(公告)号：US20230390383A1

公开(公告)日：2023-12-07

申请号：US18033039

申请日：2021-10-20

Applicant: Duke University

Inventor： Nicholas S. HEATON ,  Alanson GIRTON ,  Zhaochen LUO ,  Stacy WEBB

IPC: A61K39/215 ,  C12N7/00

CPC classification number: A61K39/215 ,  C12N7/00 ,  A61K2039/5256

Abstract: The present invention provides replication incompetent influenza viral particles comprising a modified hemagglutinin (HA) protein. Also provided are methods for making and using the viral particles, and cell lines for making the viral particles.