公开(公告)号：US11369570B2

公开(公告)日：2022-06-28

申请号：US14360503

申请日：2012-09-21

Applicant: ECOSYNTHETIX LTD.

Inventor： Steven Bloembergen ,  Ian J. McLennan ,  Nathan Jones ,  Areet Krsna Ganesh Shermon ,  Abdel Elsayed ,  Juewen Liu

IPC: A61K9/26 ,  A61K9/14 ,  A61K9/51 ,  B82Y5/00 ,  A61K9/16 ,  C08B31/18 ,  C08B33/00 ,  C08B35/00 ,  A61K47/54 ,  A61K47/69 ,  C08B31/00 ,  A61K31/704 ,  A61K47/36

Abstract: A delivery device for a active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders, such as cancer. The delivery device survives for a period of time in the body sufficient to allow for transport and uptake of the delivery device into targeted cells. The degree of crosslinking can provide a desired release profile of the active agent at, near or inside the target cells. The nanoparticles may be made by applying a high shear force in the presence of a cross linker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water.

公开(公告)号：US20150025029A1

公开(公告)日：2015-01-22

申请号：US14360503

申请日：2012-09-21

Applicant: ECOSYNTHETIX LTD.

Inventor： Steven Bloembergen ,  Ian J. McLennan ,  Nathan Jones ,  Areet Krsna Ganesh Shermon ,  Abdel Elsayed ,  Juewen Liu

IPC: A61K47/36 ,  A61K31/704

CPC classification number: A61K9/145 ,  A61K9/1676 ,  A61K9/5161 ,  A61K31/704 ,  A61K47/36 ,  A61K47/549 ,  A61K47/6939 ,  B82Y5/00 ,  C08B31/003 ,  C08B31/185 ,  C08B33/00 ,  C08B35/00 ,  Y10S977/773 ,  Y10S977/906 ,  Y10T428/2982

Abstract: A delivery device for a active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders, such as cancer. The delivery device survives for a period of time in the body sufficient to allow for transport and uptake of the delivery device into targeted cells. The degree of crosslinking can provide a desired release profile of the active agent at, near or inside the target cells. The nanoparticles may be made by applying a high shear force in the presence of a cross linker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water.

Abstract translation: 用于活性剂的递送装置包括基于诸如淀粉的生物聚合物的纳米颗粒。 递送装置还可以是适体 - 生物聚合物 - 活性剂缀合物的形式，其中适体靶向用于治疗特定疾病例如癌症的装置。 递送装置在身体中存活足够长的时间以允许将递送装置运输和摄取到靶细胞中。 交联度可以提供活性剂在靶细胞附近或内部的所需释放曲线。 可以通过在交联剂的存在下施加高剪切力来制备纳米颗粒。 颗粒可以主要在50-150nm的范围内，并形成交联的水凝胶颗粒在水中的胶态分散体。