公开(公告)号：US11453798B2

公开(公告)日：2022-09-27

申请号：US15100512

申请日：2013-12-05

Applicant: ECOSYNTHETIX LTD.

Inventor： Uttam Kumar Saha ,  Steven Bloembergen

IPC: C09D103/02 ,  B29B7/90 ,  B29B7/38 ,  D04H1/64 ,  C09J103/02 ,  D04H1/587 ,  C08B31/00 ,  C09D161/02 ,  B29B7/46

Abstract: This patent describes formaldehyde free or formaldehyde reduced binders useful, for example, in a fiber based composite material such as glass or other mineral fiber insulation, non-woven fabric or wood-based board. In one example, melamine is used as an acidic solution or a salt. The salt or solution is used to create an aqueous binder with other components such as a polyol and a crosslinker. A preferred polyol is a nanoparticle comprising high molecular weight starch. In other examples, binders include mixtures of a polyol with urea and a crosslinker. In other examples, a multi-component nanoparticle is made by reacting a polyol such as starch in an extruder with an insolubilizer such as melamine or urea. The resulting particles are mixed with water, optionally with other components such as an additional crosslinker, to create an aqueous binder.

公开(公告)号：US11369570B2

公开(公告)日：2022-06-28

申请号：US14360503

申请日：2012-09-21

Applicant: ECOSYNTHETIX LTD.

Inventor： Steven Bloembergen ,  Ian J. McLennan ,  Nathan Jones ,  Areet Krsna Ganesh Shermon ,  Abdel Elsayed ,  Juewen Liu

IPC: A61K9/26 ,  A61K9/14 ,  A61K9/51 ,  B82Y5/00 ,  A61K9/16 ,  C08B31/18 ,  C08B33/00 ,  C08B35/00 ,  A61K47/54 ,  A61K47/69 ,  C08B31/00 ,  A61K31/704 ,  A61K47/36

Abstract: A delivery device for a active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders, such as cancer. The delivery device survives for a period of time in the body sufficient to allow for transport and uptake of the delivery device into targeted cells. The degree of crosslinking can provide a desired release profile of the active agent at, near or inside the target cells. The nanoparticles may be made by applying a high shear force in the presence of a cross linker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water.

公开(公告)号：US20150025029A1

公开(公告)日：2015-01-22

申请号：US14360503

申请日：2012-09-21

Applicant: ECOSYNTHETIX LTD.

Inventor： Steven Bloembergen ,  Ian J. McLennan ,  Nathan Jones ,  Areet Krsna Ganesh Shermon ,  Abdel Elsayed ,  Juewen Liu

IPC: A61K47/36 ,  A61K31/704

CPC classification number: A61K9/145 ,  A61K9/1676 ,  A61K9/5161 ,  A61K31/704 ,  A61K47/36 ,  A61K47/549 ,  A61K47/6939 ,  B82Y5/00 ,  C08B31/003 ,  C08B31/185 ,  C08B33/00 ,  C08B35/00 ,  Y10S977/773 ,  Y10S977/906 ,  Y10T428/2982

Abstract: A delivery device for a active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders, such as cancer. The delivery device survives for a period of time in the body sufficient to allow for transport and uptake of the delivery device into targeted cells. The degree of crosslinking can provide a desired release profile of the active agent at, near or inside the target cells. The nanoparticles may be made by applying a high shear force in the presence of a cross linker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water.

Abstract translation: 用于活性剂的递送装置包括基于诸如淀粉的生物聚合物的纳米颗粒。 递送装置还可以是适体 - 生物聚合物 - 活性剂缀合物的形式，其中适体靶向用于治疗特定疾病例如癌症的装置。 递送装置在身体中存活足够长的时间以允许将递送装置运输和摄取到靶细胞中。 交联度可以提供活性剂在靶细胞附近或内部的所需释放曲线。 可以通过在交联剂的存在下施加高剪切力来制备纳米颗粒。 颗粒可以主要在50-150nm的范围内，并形成交联的水凝胶颗粒在水中的胶态分散体。

公开(公告)号：US20140295090A1

公开(公告)日：2014-10-02

申请号：US14123150

申请日：2012-06-04

Applicant: ECOSYNTHETIX LTD.

Inventor： Alexander Tseitlin ,  David Van Alstyne ,  Steven Bloembergen

IPC: D04H1/587 ,  C03B37/04 ,  B29C39/00

CPC classification number: D04H1/587 ,  B29C39/003 ,  C03B37/04 ,  C08J5/24 ,  C08J2303/02 ,  C08J2303/04 ,  C08K5/0025 ,  C08L1/02 ,  C08L3/04 ,  C08L23/00 ,  C08L33/08 ,  C08L61/24 ,  C08L67/00 ,  C08L77/00 ,  C08L77/02 ,  C08L89/00 ,  C08L97/02 ,  C08L2205/16 ,  C08L2205/18 ,  C09J103/04 ,  C09J161/24 ,  Y10T442/2992 ,  C08K7/04 ,  C08K7/14

Abstract: A curable aqueous binder composition comprising sheared or extruded cross linked starch particles and a crosslinking agent for use in the formation of composite materials such as mineral, natural organic or synthetic fibre products including mineral fibre insulation, non-woven mats, fibreglass insulation and related glass fibre products as well as wood based products and construction materials. In one application the curable aqueous starch binder composition may be blended with a second non-formaldehyde resin to make fibreglass insulation. In another application the curable aqueous starch binder composition may be mixed into a formaldehyde based resin to make fibreglass roof shingles.

Abstract translation: 一种可固化水性粘合剂组合物，其包含剪切或挤出的交联淀粉颗粒和用于形成复合材料的交联剂，例如矿物，天然有机或合成纤维产品，包括矿物纤维绝缘层，无纺布垫，玻璃纤维绝缘层和相关玻璃 纤维制品以及木制品和建筑材料。 在一个应用中，可固化水性淀粉粘合剂组合物可与第二非甲醛树脂共混以制备玻璃纤维绝缘体。 在另一个应用中，可固化水性淀粉粘合剂组合物可以混合成甲醛基树脂以制造玻璃纤维屋顶瓦。