公开(公告)号：US11474085B2

公开(公告)日：2022-10-18

申请号：US15963809

申请日：2018-04-26

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Rui Tostoes ,  Kedar C. Chitale ,  Benjamin Ross-Johnsrud ,  Walter M. Presz, Jr. ,  Jack Saloio

IPC: G01N30/76 ,  G01N30/46 ,  G01N30/72 ,  G01N33/543 ,  B01D15/38 ,  B01D15/18 ,  C07K1/22 ,  G01N30/02 ,  C12M1/42 ,  C12N13/00

Abstract: Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.

公开(公告)号：US20180275106A1

公开(公告)日：2018-09-27

申请号：US15963809

申请日：2018-04-26

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Rui Tostoes ,  Kedar C. Chitale ,  Benjamin Ross-Johnsrud ,  Walter M. Presz, JR. ,  Jack Saloio

IPC: G01N30/76 ,  G01N30/46 ,  G01N30/72 ,  G01N33/543

CPC classification number: G01N30/76 ,  B01D15/1807 ,  B01D15/3823 ,  B01D15/3866 ,  C07K1/22 ,  C12M35/04 ,  C12N13/00 ,  G01N30/462 ,  G01N30/7293 ,  G01N33/54313 ,  G01N2030/027

Abstract: Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.

公开(公告)号：US11459540B2

公开(公告)日：2022-10-04

申请号：US15983823

申请日：2018-05-18

Applicant: FloDesign Sonics, Inc.

Inventor： Rui Tostoes ,  Bart Lipkens ,  Kedar Chitale ,  Benjamin Ross-Johnsrud ,  Walter M. Presz, Jr. ,  Jack Saloio

IPC: C12M1/00 ,  C12M1/42 ,  B01D15/38 ,  C12N13/00 ,  B01D15/18

Abstract: Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.

公开(公告)号：US20190011407A9

公开(公告)日：2019-01-10

申请号：US15963809

申请日：2018-04-26

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Rui Tostoes ,  Kedar C. Chitale ,  Benjamin Ross-Johnsrud ,  Walter M. Presz, JR. ,  Jack Saloio

IPC: G01N30/76 ,  G01N30/46 ,  G01N30/72 ,  G01N33/543

Abstract: Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.

公开(公告)号：USD797887S1

公开(公告)日：2017-09-19

申请号：US29562478

申请日：2016-04-26

Applicant: FloDesign Sonics, Inc.

Designer： Bart Lipkens ,  Walter M. Presz, Jr. ,  Jason Barnes ,  Dane Mealey ,  Jeffrey King ,  Brian McCarthy ,  Jack Saloio ,  Kedar Chitale ,  Benjamin Ross-Johnsrud

公开(公告)号：US20220250076A1

公开(公告)日：2022-08-11

申请号：US17753194

申请日：2020-08-27

Applicant: FloDesign Sonics, Inc.

Inventor： Rui Tostoes ,  Bart Lipkens ,  Kedar C. Chitale ,  Benjamin Ross-Johnsrud ,  Walter M. Presz, JR. ,  Jack Saloio

IPC: B01L3/00 ,  B01D21/28 ,  B01D15/18 ,  B01D15/38

Abstract: Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.

公开(公告)号：US20200215109A1

公开(公告)日：2020-07-09

申请号：US16244100

申请日：2019-01-09

Applicant: FLODESIGN SONICS, INC.

Inventor： Bart Lipkens ,  Rui Tostoes ,  Walter M. Presz, JR. ,  Benjamin Ross-Johnsrud ,  Kedar Chitale ,  Thomas J. Kennedy, III ,  Brian Dutra ,  Brian McCarthy ,  Jack Saloio

IPC: A61K35/17 ,  B01L3/00 ,  C12M1/00 ,  C12N13/00

Abstract: A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.

公开(公告)号：US20220186174A1

公开(公告)日：2022-06-16

申请号：US17610572

申请日：2020-05-15

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Benjamin Ross-Johnsrud ,  Kedar C. Chitale ,  Krishna N. Kumar ,  Jack Saloio

IPC: C12M1/00 ,  C12N13/00 ,  B01D21/28 ,  B01D21/30

Abstract: An acoustic wave with an acoustic field with a large number of multi-directional gradients can provide an edge effect that be used to form an interface region relative to the acoustic wave. The interface region can block material with certain characteristics related to the nature of the interface region. Other material that is less influenced by the acoustic properties of the interface region can pass through the acoustic wave. This technique permits separation of materials using the edge effect and interface region.

公开(公告)号：US10710006B2

公开(公告)日：2020-07-14

申请号：US15497078

申请日：2017-04-25

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Jeffrey King ,  Jack Saloio ,  Brian McCarthy

IPC: B01D17/12 ,  B06B1/06 ,  B01D21/28

Abstract: Transducer assemblies that can be used in acoustophoretic systems are disclosed. The acoustophoretic systems including the transducer assemblies and methods of operating the acoustophoretic systems are also disclosed. The transducer assemblies include a housing, a polymeric film attached to the housing, and a piezoelectric material attached to the polymeric film. The piezoelectric material is not attached to, and does not come in direct contact with, the housing. The piezoelectric material is configured to be driven by a drive signal to create a multi-dimensional acoustic standing wave. The piezoelectric material can be attached to the polymer film by an adhesive coating on the polymer film.

公开(公告)号：US20200206730A1

公开(公告)日：2020-07-02

申请号：US16557994

申请日：2019-08-30

Applicant: FloDesign Sonics, Inc.

Inventor： Rui Tostoes ,  Bart Lipkens ,  Kedar C. Chitale ,  Benjamin Ross-Johnsrud ,  Walter M. Presz, JR. ,  Jack Saloio

IPC: B01L3/00

Abstract: Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.