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    SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING
    3.
    发明申请
    SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING 审中-公开

    公开(公告)号：US20190256903A1

    公开(公告)日：2019-08-22

    申请号：US16141215

    申请日：2018-09-25

    Applicant: GenapSys, Inc.

    Inventor： Hesaam Esfandyarpour ,  Maryam Jouzi ,  Seth Stern ,  Paul Kenney

    IPC: C12Q1/6869 ,  C12Q1/6825

    Abstract: The present disclosure provides methods and systems for sequencing nucleic acid molecules. Methods may include sequencing double-stranded nucleic acids or single-stranded nucleic acids. Sequencing may include the use of nucleotides coupled to electrostatic moieties. The electrostatic moieties may be detected by a sensor array. The electrostatic moieties may be reversible electrostatic moieties that are cleaved from the nucleic acid molecule after incorporation of the nucleotide. The electrostatic moieties may be irreversible electrostatic moieties. Nucleotides comprising irreversible electrostatic moieties may be incorporated into the nucleic acid molecule, detected by the sensor array, and exchanged for non-detectable nucleotides.

    SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING
    5.
    发明申请
    SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING 有权

    公开(公告)号：US20220186303A1

    公开(公告)日：2022-06-16

    申请号：US17383716

    申请日：2021-07-23

    Applicant: GenapSys, Inc.

    Inventor： Hesaam Esfandyarpour ,  Maryam Jouzi ,  Seth Stern ,  Paul Kenney

    IPC: C12Q1/6869 ,  C12Q1/6825

    Abstract: The present disclosure provides methods and systems for sequencing nucleic acid molecules. Methods may include sequencing double-stranded nucleic acids or single-stranded nucleic acids. Sequencing may include the use of nucleotides coupled to electrostatic moieties. The electrostatic moieties may be detected by a sensor array. The electrostatic moieties may be reversible electrostatic moieties that are cleaved from the nucleic acid molecule after incorporation of the nucleotide. The electrostatic moieties may be irreversible electrostatic moieties. Nucleotides comprising irreversible electrostatic moieties may be incorporated into the nucleic acid molecule, detected by the sensor array, and exchanged for non-detectable nucleotides.

    MICROFLUIDIC DEVICES, SYSTEMS AND METHODS FOR SAMPLE PREPARATION AND ANALYSIS
    8.
    发明申请
    MICROFLUIDIC DEVICES, SYSTEMS AND METHODS FOR SAMPLE PREPARATION AND ANALYSIS 审中-公开

    公开(公告)号：US20200206736A1

    公开(公告)日：2020-07-02

    申请号：US16534412

    申请日：2019-08-07

    Applicant: GenapSys, Inc.

    Inventor： Seth Stern ,  Hesaam Esfandyarpour ,  David Eberhart

    IPC: B01L3/00 ,  C12N15/10 ,  B01L7/00 ,  B01F5/02 ,  B01F13/00 ,  B01F3/08 ,  F16K99/00 ,  C12Q1/6806 ,  C12Q1/6869

    Abstract: The present disclosure provides microfluidic devices, systems and methods for sample preparation and/or analysis. A microfluidic device can include a first channel having a sequence of (n) chambers each having a first volume (v). The first channel can include one or more valves at opposing ends of the first channel that fluidically isolate the first channel. The microfluidic device can further include a second channel in fluid communication with the first channel. The second channel can include at least one second chamber having a total second volume that is at least equal to the total volume of the first channel (n*v). The second channel can include one or more valves at opposing ends of the second channel that fluidically isolate the second channel from the first channel.

    Systems and methods for nucleic acid sequencing
    10.
    发明授权
    Systems and methods for nucleic acid sequencing 有权

    公开(公告)号：US10900075B2

    公开(公告)日：2021-01-26

    申请号：US16141215

    申请日：2018-09-25

    Applicant: GenapSys, Inc.

    Inventor： Hesaam Esfandyarpour ,  Maryam Jouzi ,  Seth Stern ,  Paul Kenney

    IPC: C12Q1/6869 ,  C12Q1/6825 ,  C12Q1/6837

    Abstract: The present disclosure provides methods and systems for sequencing nucleic acid molecules. Methods may include sequencing double-stranded nucleic acids or single-stranded nucleic acids. Sequencing may include the use of nucleotides coupled to electrostatic moieties. The electrostatic moieties may be detected by a sensor array. The electrostatic moieties may be reversible electrostatic moieties that are cleaved from the nucleic acid molecule after incorporation of the nucleotide. The electrostatic moieties may be irreversible electrostatic moieties. Nucleotides comprising irreversible electrostatic moieties may be incorporated into the nucleic acid molecule, detected by the sensor array, and exchanged for non-detectable nucleotides.

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