公开(公告)号：US20230102772A1

公开(公告)日：2023-03-30

申请号：US18057360

申请日：2022-11-21

Applicant: GLYCOM A/S

Inventor： Benjámin PODÁNYI ,  Pierre CHASSAGNE ,  Martin MATWIEJUK ,  Markus JONDELIUS HEDEROS

IPC: C07H3/06 ,  C07H1/00 ,  C07H3/02

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US20220089629A1

公开(公告)日：2022-03-24

申请号：US17310039

申请日：2020-01-16

Applicant: GLYCOM A/S

Inventor： Benjámin PODÁNYI ,  Martin MATWIEJUK ,  Dóra MOLNÁR-GÁBOR

IPC: C07H3/06 ,  C07H1/00

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US20230099060A1

公开(公告)日：2023-03-30

申请号：US18057355

申请日：2022-11-21

Applicant: GLYCOM A/S

Inventor： Benjámin PODÁNYI ,  Pierre CHASSAGNE ,  Martin MATWIEJUK ,  Markus JONDELIUS HEDEROS

IPC: C07H3/06 ,  C07H1/00 ,  C07H3/02

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US20200299740A1

公开(公告)日：2020-09-24

申请号：US16895871

申请日：2020-06-08

Applicant: Glycom A/S

Inventor： Gyula DEKANY ,  Györgyi OSZTROVSZKY ,  Martin MATWIEJUK ,  Pierre CHASSAGNE ,  Markus JONDELIUS HEDEROS

IPC: C12P19/18 ,  C07H1/06 ,  C07H3/06

Abstract: The invention relates to a method for selective crystallization of 2′-fucosyllactose (2′-FL) from an aqueous solution comprising 2′-FL and one or more other fucosylated carbohydrates by adding acetic acid to the solution. The aqueous solution is separated from an aqueous culture medium prior to crystallization.

公开(公告)号：US20180002363A1

公开(公告)日：2018-01-04

申请号：US15703551

申请日：2017-09-13

Applicant: GLYCOM A/S

Inventor： Martin MATWIEJUK ,  Markus HEDEROS

IPC: C07H1/08 ,  C12P19/04 ,  C07H23/00 ,  C12P19/18 ,  B01D15/36

Abstract: The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.

公开(公告)号：US20240124509A1

公开(公告)日：2024-04-18

申请号：US18257979

申请日：2021-12-17

Applicant: GLYCOM A/S

Inventor： Martin MATWIEJUK

IPC: C07H7/033 ,  B01D15/36 ,  B01J41/07 ,  C07H1/06

CPC classification number: C07H7/033 ,  B01D15/363 ,  B01J41/07 ,  C07H1/06

Abstract: The present invention concerns a method for separating different oligosaccharides having at least one carboxylic acid group by contacting them with basic anion exchange resins.

公开(公告)号：US20230030220A1

公开(公告)日：2023-02-02

申请号：US17757646

申请日：2020-12-18

Applicant: Glycom A/S

Inventor： Nikolay KHANZHIN ,  Getachew S. MOLLA ,  Martin MATWIEJUK ,  Pierre CHASSAGNE

IPC: C12P19/04 ,  B01D61/14 ,  B01D61/58 ,  B01D69/02 ,  B01D71/56 ,  C12P19/26

Abstract: The present invention relates to the separation and isolation of sialylated human milk oligosaccharides (HMOs) from the reaction mixture in which they are produced.

公开(公告)号：US20190119314A1

公开(公告)日：2019-04-25

申请号：US16094508

申请日：2017-04-19

Applicant: GLYCOM A/S

Inventor： Pierre CHASSAGNE ,  Nikolay KHANZHIN ,  Martin MATWIEJUK ,  Markus JONDELIUS HEDEROS ,  Niels BANKE

IPC: C07H13/04 ,  C07H1/06 ,  B01D61/02 ,  B01D61/14 ,  C12P19/28 ,  B01D61/58

Abstract: The invention relates to a method for obtaining an N-acetylglucosamine containing neutral oligosaccharide from a fermentation broth, wherein said oligosaccharide is produced by culturing a genetically modified microorganism capable of producing said oligosaccharide from an internalized carbohydrate precursor, comprising the steps of: i) ultrafiltration (UF), preferably to separate biomass from the broth, ii) nanofiltration (NF), preferably to concentrate said oligosaccharide in the broth and/or reduce an inorganic salt content of the broth, and iii) treating the broth with an ion exchange resin, preferably to remove charged materials, and/or subjecting the broth to chromatography, preferably to remove hydrophobic impurities.

公开(公告)号：US20220340942A1

公开(公告)日：2022-10-27

申请号：US17754400

申请日：2020-10-01

Applicant: Glycom A/S

Inventor： Nikolay KHANZHIN ,  Pierre CHASSAGNE ,  Flemming MATHIESEN ,  Jesper THØGERSEN ,  Martin MATWIEJUK

IPC: C12P19/00 ,  B01D61/14 ,  B01D61/16 ,  B01D61/58 ,  B01J39/05

Abstract: The present invention relates to the separation and isolation of neutral human milk oligosaccharides (HMOs) from the reaction mixture in which they are produced.

公开(公告)号：US20190248824A1

公开(公告)日：2019-08-15

申请号：US16346057

申请日：2017-10-31

Applicant: Glycom A/S

Inventor： Pierre CHASSAGNE ,  Martin MATWIEJUK ,  Nikolay KHANZHIN ,  Markus JONDELIUS HEDEROS

IPC: C07H3/06 ,  C07H1/06 ,  A61K31/702 ,  A23L33/21 ,  F26B5/04 ,  F26B21/14

CPC classification number: C07H3/06 ,  A23L33/21 ,  A23V2002/00 ,  A61K31/702 ,  C07B2200/13 ,  C07H1/00 ,  C07H1/06 ,  C07H13/04 ,  F26B5/04 ,  F26B21/14

Abstract: The present invention relates to a method of removing residual organic solvent from crystalline oligosaccharides by the use of water vapour as well as the pharmaceutically and nutritionally suitable crystalline oligosaccharides obtained by said method.