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公开(公告)号：US20170131306A1
公开(公告)日：2017-05-11
申请号：US15126789
申请日：2015-03-09
Applicant: Hitachi High-Technologies Corporation
Inventor： Shinji TARUMI , Sakuichiro ADACHI , Chie YABUTANI , Akihisa MAKINO
CPC classification number: G01N35/00871 , G01N21/272 , G01N21/51 , G01N21/59 , G01N33/4905 , G01N33/86 , G01N2021/135 , G01N2021/513 , G01N2021/825 , G01N2201/12753 , G01N2201/12792 , G16H10/40 , G16H50/20
Abstract: An automatic analytical apparatus includes a reaction container for mixing a sample with a reagent to react the sample to the reagent, a measurement unit that irradiates a reaction solution in the reaction container with light and measures the intensity of transmitted light or scattered light, a control unit that processes time-series light intensity data obtained through the measurement in the measurement unit, a storage unit that stores one or more approximation functions each approximating to a time-series change in the light intensity data, and an output unit that outputs a processing result of the control unit. The control unit selects any one of the approximation functions stored in the storage unit, calculates an approximate curve indicating a time-series change in the light intensity data using the selected approximation function, calculates deviation feature information based on deviation information between the light intensity data and the approximate curve, and detects and classifies an abnormality included in the light intensity data using the deviation feature information.
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公开(公告)号：US20170328925A1
公开(公告)日：2017-11-16
申请号：US15517630
申请日：2015-09-18
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Minoru SANO , Akihisa MAKINO , Chie YABUTANI , Rei KONISHI , Naoto SUZUKI
Abstract: The purpose of the present invention is to provide an automatic analysis device capable of efficiently performing a plurality of analyses, while reducing the footprint and cost of the device. Provided is an automatic analysis device characterized by being provided with containers for containing samples, one rack for placing the containers thereon, and a control unit, the control unit generating, with respect to the one rack, a plurality of registration patterns in which information of the positions where the containers are disposed, and information of the samples contained in the containers are correlated with each other, storing the registration patterns thus generated, applying, to the one rack, one registration pattern selected from among the registration patterns thus stored, and analyzing the samples. Also provided is an analysis method using the device.
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公开(公告)号：US20170212138A1
公开(公告)日：2017-07-27
申请号：US15326820
申请日：2015-06-10
Applicant: Hitachi High-Technologies Corporation
Inventor： Tatsuya SAKAI , Akihisa MAKINO , Minoru SANO , Chie YABUTANI
CPC classification number: G01N35/025 , G01N33/86 , G01N35/00 , G01N35/00069 , G01N35/0099 , G01N35/04 , G01N35/1002 , G01N2035/0441 , G01N2035/0453
Abstract: Provided is an automatic analysis apparatus for inspecting blood coagulation, which is capable of miniaturizing device configuration and reducing device costs. The automatic analysis apparatus includes: a reaction container in which a specimen and a reagent are mixed with each other and the mixed solution is reacted; a sample dispensing mechanism which dispenses the specimen into the reaction container; a blood coagulation time measuring unit in which the reaction container is mounted to measure a coagulation time of the mixed solution within the reaction container; a reaction container accommodating unit which accommodates a plurality of reaction containers provided to the blood coagulation measuring unit; a reaction container transfer mechanism which grasps the reaction container and transfers the reaction container to the blood coagulation measuring unit; and a control unit which controls the reaction container transfer mechanism, wherein the control unit controls the transferring and mounting of the reaction container, into which the specimen is dispensed, to the reaction container accommodating unit by means of the reaction container transfer mechanism.
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公开(公告)号：US20160291046A1
公开(公告)日：2016-10-06
申请号：US14777550
申请日：2014-03-19
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Chie YABUTANI , Akihisa MAKINO , Sakuichiro ADACHI
CPC classification number: G01N35/00693 , G01N21/272 , G01N21/82 , G01N33/86 , G01N35/0092 , G01N2035/00702 , G01N2035/0097
Abstract: A detection unit 113 measures scattered light intensity E as a coagulation index. A first curve fitting function 120B-a c calculates, at a predetermined time interval, a parameter for an approximate curve of a coagulation curve by curve fitting, based on the measured scattered light intensity E. An early reaction checking function 120B-b determines whether there is a lag phase as an early coagulation index change, based on the parameter for the approximate curve. The parameter has been calculated at the predetermined time interval by the first curve fitting function 120B-a. A clotting time calculation function 120B-f calculates clotting time, based on whether there is the lag phase.
Abstract translation: 检测单元113测量作为凝结指数的散射光强度E. 第一曲线拟合函数120B-ac基于所测量的散射光强度E，以预定的时间间隔计算用于曲线拟合的凝固曲线的近似曲线的参数。早期反应检查功能120B-b确定是否存在 作为早期凝血指数变化的滞后期，基于近似曲线的参数。 已经通过第一曲线拟合函数120B-a以预定时间间隔计算了参数。 凝血时间计算功能120B-f基于是否存在滞后期来计算凝血时间。
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公开(公告)号：US20160209437A1
公开(公告)日：2016-07-21
申请号：US15083809
申请日：2016-03-29
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Chie YABUTANI , Shigeki MATSUBARA
IPC: G01N35/00
CPC classification number: G01N35/0092 , B01F7/161 , B01F11/0283 , B01F15/00253 , B01F15/00324 , B01F15/00435 , B01F2015/00629 , B01F2015/00636 , B01F2015/0221 , G01N1/38 , G01N35/025 , G01N35/1002 , G01N2035/00514 , G01N2035/00554 , G01N2035/0444 , Y10T436/25 , Y10T436/25625
Abstract: In the field of automatic analyzers, as items to be analyzed are increase, various reagents differing in such properties as liquid viscosity and contact angle are being used more frequently, and this trend is expected to continue. Also, reagents now take various forms (e.g., a concentrated reagent to be diluted by the water of an automatic analyzer), and so does dilution water. Such being the case, the invention provides an automatic analyzer capable of sufficient stirring regardless of items to be analyzed. To sufficiently stir a substance to which a reagent has been added, the automatic analyzer is designed to alter stirring conditions after a given amount of time has passed since the addition of that reagent.
Abstract translation: 在自动分析仪领域，随着分析项目的增加，液体粘度和接触角等特性不同的各种试剂的使用频率较高，预计这一趋势将继续下去。 此外，试剂现在采取各种形式（例如，由自动分析仪的水稀释的浓缩试剂），稀释水也是如此。 在这种情况下，本发明提供了能够充分搅拌的自动分析器，而不管要分析的物品。 为了充分搅拌添加有试剂的物质，自动分析装置被设计成在添加该试剂经过规定时间后改变搅拌条件。
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Patent Agency Ranking
公开(公告)号：US20150316531A1
公开(公告)日：2015-11-05
申请号：US14646150
申请日：2013-11-05
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Shinji TARUMI , Chie YABUTANI , Akihisa MAKINO , Chihiro MANRI , Satoshi MITSUYAMA
CPC classification number: G01N21/82 , G01N21/17 , G01N21/25 , G01N21/27 , G01N21/272 , G01N30/8693 , G01N33/49 , G01N33/4905 , G01N33/53 , G01N33/86 , G01N35/00 , G01N35/00584 , G01N2021/513 , G01N2021/5961 , G01N2035/00425 , G01N2035/00702 , G01N2035/0097 , G01N2035/0453 , G06F19/00 , G06F19/321
Abstract: Provided is technology for blood clotting reactions capable of analyzing a blood clotting reaction with a high degree of precision, by precisely detecting and removing noise, regardless of the location where the noise is generated in the light intensity data. This automated analyzer approximates, with an approximation curve, time series data for transmitted light intensity or scattered light intensity of light emitted onto a sample, and, in this process, removes abnormal data points that deviate from the approximation curve (see FIG. 2).
Abstract translation: 提供了能够通过精确地检测和去除噪声来分析凝血反应的高精度的血液凝固反应的技术，而不管光强数据中产生噪声的位置如何。 该自动分析仪用近似曲线近似发射到样品上的光的透射光强度或散射光强度的时间序列数据，并且在该过程中，去除偏离近似曲线的异常数据点（参见图2） 。
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公开(公告)号：US20200271677A1
公开(公告)日：2020-08-27
申请号：US16646386
申请日：2018-09-06
Applicant: Hitachi High-Technologies Corporation
Inventor： Yuto KAZAMA , Masahiko IIJIMA , Chie YABUTANI , Kenji KOGURE
Abstract: The present invention makes it possible for an automated analyzer including two or more types of photometers to obtain suitable output of the measurement results of the plurality of photometers and suitable data alarm output even if there is an abnormality, or the like, at the time of measurement. This automated analyzer includes, for example, two types of photometers having different quantitative ranges and an analysis control unit for controlling analysis that includes measurement of a given sample using the two types of photometers. If two types of data alarms corresponding to abnormalities, or the like, during measurement have been added to the two types of measurement results from the two types of photometers, the analysis control unit selects measurement result and data alarm output corresponding to the combination of the two types of data alarms and outputs the same to a user as analysis results.
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公开(公告)号：US20200241024A1
公开(公告)日：2020-07-30
申请号：US16479687
申请日：2018-02-15
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Chie YABUTANI , Takumi YAMADA , Masahiko IIJIMA
Abstract: An automatic analysis device is provided with: a sample disk for holding a sample container that accommodates a sample; a reagent disk for holding a reagent container that accommodates a reagent; at least two different measuring units that respectively perform different types of analyses; a control part that controls the measuring units; and a display part that displays: a work flow area in which the flow of operation of the two or more measuring units is displayed; and an overview area in which the usable or unusable states of the respective measuring units are displayed, wherein the overview area has a unit necessity-of-use selection part that can select whether using each of the measuring units is necessary, and the control part controls the display part so as to change the display of the work flow area on the basis of the information set in the unit necessity-of-use selection part.
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公开(公告)号：US20190339295A1
公开(公告)日：2019-11-07
申请号：US15758993
申请日：2016-07-25
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Akihisa MAKINO , Toshiyuki INABE , Chie YABUTANI
Abstract: In blood coagulation time measurement, the reaction time relies on the blood coagulation ability of a specimen and is not fixed. In particular, in module-type devices, errors may occur in the specimen processing, measurement number, and measurement time between a plurality of blood coagulation analysis units, leading to the risk of lowering the processing capability of the device as a whole. The present invention is a module-type automated analyzer provided with a plurality of blood coagulation analysis units capable of analyzing blood coagulation time items in which the reaction time between a specimen and a reagent differs depending on the specimen, wherein a control unit that controls the specimen rack conveying operation finds the total of forecasted measurement times of measurement items requested for specimens being analyzed and queued specimens in each of the plurality of blood coagulation analysis units, and determines the conveyance destination of the specimen rack on the basis of the total of the forecasted measurement times that was found.
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公开(公告)号：US20180080948A1
公开(公告)日：2018-03-22
申请号：US15554276
申请日：2016-02-12
Applicant: Hitachi High-Technologies Corporation
Inventor： Chie YABUTANI , Naoto SUZUKI , Akihisa MAKINO
Abstract: The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light.
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