公开(公告)号：US20150367348A1

公开(公告)日：2015-12-24

申请号：US14762222

申请日：2014-01-27

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Minoru SANO ,  Yoshiyuki SHOJI ,  Koshi MAEDA

IPC: B01L7/00

CPC classification number: B01L7/5255 ,  B01L3/5082 ,  B01L2200/147 ,  B01L2300/0803 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1844

Abstract: A nucleic acid amplification apparatus which amplifies a nucleic acid of a reaction liquid in which a specimen and a reagent are mixed includes a carousel which is provided with a plurality of temperature control blocks, each of which holds at least one reaction container in which a reaction liquid is stored, a temperature control device which is provided in the carousel, temperature control devices which are respectively provided in a plurality of temperature control blocks and adjust the temperature of the reaction liquid, a temperature control device which adjusts the temperature of the atmospheric temperature inside the nucleic acid amplification apparatus, and a control device which detects a failure from a result of measuring the temperature.

Abstract translation: 扩增其中混合有试样和试剂的反应液的核酸的核酸扩增装置包括设置有多个温度控制块的转盘，每个温度控制块保持至少一个反应容器，其中反应 存储液体，设置在转盘中的温度控制装置，分别设置在多个温度控制块中并调节反应液的温度的温度控制装置，调节大气温度的温度控制装置 在核酸扩增装置内部，以及从测定温度的结果检测出故障的控制装置。

公开(公告)号：US20160299167A1

公开(公告)日：2016-10-13

申请号：US15100399

申请日：2014-12-10

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Minoru SANO

IPC: G01N35/10 ,  C12Q1/68

CPC classification number: G01N35/1016 ,  C12Q1/686 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/1025

Abstract: Provided is an analyzer (1) that is provided with a liquid level detection function or a droplet collection function and a cold retention function; efficiently uses a reagent, sample, or other liquid collected in a container (22); and carries out highly accurate analysis. This analyzer (1) is provided with a dispenser (2), a dispensing tip (21) attached to the dispenser (2), a container (22) for containing liquid sucked in by the dispenser (2), a holder (23) for holding the container (22), a conductor (24) covering the outer surface of the container, a control unit (4) for detecting the capacitance between the dispensing tip (21) and the conductor (24) and/or controlling the electric field between a pair of electrodes (41, 42), and a cold retention device (60) for keeping the container (22) cold. The container (22) has at least two cross-sectional shapes (S1, S2) for which the cross-sectional areas in the horizontal direction are smaller at deeper positions.

Abstract translation: 提供了具有液位检测功能或液滴收集功能和冷保持功能的分析器（1） 有效地使用收集在容器（22）中的试剂，样品或其他液体; 并进行高精度分析。 该分析器（1）设置有分配器（2），附接到分配器（2）的分配尖端（21），用于容纳由分配器（2）吸入的液体的容器（22），保持器（23） 用于保持容器（22），覆盖容器的外表面的导体（24），用于检测分配尖端（21）和导体（24）之间的电容的控制单元（4）和/或控制电 一对电极（41,42）之间的电场以及用于保持容器（22）冷的冷保持装置（60）。 容器（22）具有至少两个横截面形状（S1，S2），在深度位置上水平方向上的横截面积较小。

公开(公告)号：US20160144366A1

公开(公告)日：2016-05-26

申请号：US14898286

申请日：2014-06-18

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kimikazu SUGIYAMA ,  Minoru SANO ,  Yasunori SHOJI ,  Yoshiyuki SHOJI ,  Yuki KIKUCHI ,  Manami NAMMOKU ,  Ryoji INABA

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2300/046 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2300/1822 ,  B01L2300/1844 ,  B01L2300/1883

Abstract: When taking in outside air with a fan to control the temperature inside a covered portion where a specimen is installed, the internal temperature may change depending on an environment temperature to cause a difference in temperature control. The wind generated by the fan may blow against a reaction container depending on its loading position and it may influence the temperature control over individual specimens and lead to problems with temperature accuracy, temperature rise speed, and temperature drop speed A reaction container avoiding these problems has a covered portion which performs temperature control on the reaction container and in which a cover and a fin cover have a heat insulating structure. A heat source is provided for controlling an internal temperature of an internal covered space. The internal temperature is kept constant and the influence of the environment temperature over the temperature control of the reaction container is minimized.

Abstract translation: 当用风扇吸入外部空气来控制安装样品的覆盖部分内的温度时，内部温度可能根据环境温度而变化，从而导致温度差异。 风扇产生的风可能会因反应容器的装载位置而受到冲击，可能影响单个样品的温度控制，导致温度精度，升温速度和温度下降速度的问题。避免这些问题的反应容器 在反应容器上进行温度控制的盖部，盖和翅片盖具有隔热结构。 提供了一种用于控制内部覆盖空间的内部温度的热源。 内部温度保持恒定，并且环境温度对反应容器的温度控制的影响最小化。

公开(公告)号：US20170328925A1

公开(公告)日：2017-11-16

申请号：US15517630

申请日：2015-09-18

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Minoru SANO ,  Akihisa MAKINO ,  Chie YABUTANI ,  Rei KONISHI ,  Naoto SUZUKI

IPC: G01N35/00 ,  G01N21/51 ,  G01N1/38 ,  G01N35/02 ,  G01N21/82 ,  G01N21/77

Abstract: The purpose of the present invention is to provide an automatic analysis device capable of efficiently performing a plurality of analyses, while reducing the footprint and cost of the device. Provided is an automatic analysis device characterized by being provided with containers for containing samples, one rack for placing the containers thereon, and a control unit, the control unit generating, with respect to the one rack, a plurality of registration patterns in which information of the positions where the containers are disposed, and information of the samples contained in the containers are correlated with each other, storing the registration patterns thus generated, applying, to the one rack, one registration pattern selected from among the registration patterns thus stored, and analyzing the samples. Also provided is an analysis method using the device.

公开(公告)号：US20170212138A1

公开(公告)日：2017-07-27

申请号：US15326820

申请日：2015-06-10

Applicant: Hitachi High-Technologies Corporation

Inventor： Tatsuya SAKAI ,  Akihisa MAKINO ,  Minoru SANO ,  Chie YABUTANI

IPC: G01N35/02 ,  G01N35/00 ,  G01N33/86 ,  G01N35/10

CPC classification number: G01N35/025 ,  G01N33/86 ,  G01N35/00 ,  G01N35/00069 ,  G01N35/0099 ,  G01N35/04 ,  G01N35/1002 ,  G01N2035/0441 ,  G01N2035/0453

Abstract: Provided is an automatic analysis apparatus for inspecting blood coagulation, which is capable of miniaturizing device configuration and reducing device costs. The automatic analysis apparatus includes: a reaction container in which a specimen and a reagent are mixed with each other and the mixed solution is reacted; a sample dispensing mechanism which dispenses the specimen into the reaction container; a blood coagulation time measuring unit in which the reaction container is mounted to measure a coagulation time of the mixed solution within the reaction container; a reaction container accommodating unit which accommodates a plurality of reaction containers provided to the blood coagulation measuring unit; a reaction container transfer mechanism which grasps the reaction container and transfers the reaction container to the blood coagulation measuring unit; and a control unit which controls the reaction container transfer mechanism, wherein the control unit controls the transferring and mounting of the reaction container, into which the specimen is dispensed, to the reaction container accommodating unit by means of the reaction container transfer mechanism.

公开(公告)号：US20150024401A1

公开(公告)日：2015-01-22

申请号：US14508338

申请日：2014-10-07

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Minoru SANO ,  Masato ISHIZAWA ,  Shuhei YAMAMOTO

IPC: C12Q1/68

CPC classification number: C12Q1/68 ,  B01L7/52 ,  G01N21/0332 ,  G01N21/645 ,  G01N21/6452 ,  G01N35/025 ,  G01N2035/00366

Abstract: An object of the present invention relates to providing a nucleic acid analyzer capable of testing a plurality of test items in parallel, and of obtaining high efficiency of specimen processing even if the test item or a measuring object is changed. The present invention relates to an analyzer including a carousel rotatable about a rotation axis, a plurality of reaction containers held along a circumferential edge of the carousel, and at least one detector having a light source for irradiating the reaction container with excitation light and a detection element for detecting fluorescence from a reaction liquid in the reaction container. The detector is removable. By attaching a desired detector, it is possible to perform fluorescence measurement in response to the test item. According to the present invention, it is possible to test a plurality of test items in parallel, and even if the test item or the measuring object is changed, the high efficiency of specimen processing can be obtained.

Abstract translation: 本发明的目的是提供一种能够并行地测试多个测试项目的核酸分析仪，并且即使测试项目或测量对象改变也能获得高效率的样本处理。 本发明涉及一种分析仪，其包括可围绕旋转轴线旋转的圆盘传送带，沿圆盘传送带的圆周边缘保持的多个反应容器，以及至少一个检测器，具有用于向反应容器照射激发光和检测光的源 用于检测来自反应容器中的反应液体的荧光的元件。 检测器是可拆卸的。 通过附加所需的检测器，可以响应于测试项目执行荧光测量。 根据本发明，可以并行地进行多个测试项目的测试，即使测试项目或测量对象发生变化，也能够获得高效的样本处理。