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公开(公告)号：US20180275053A1
公开(公告)日：2018-09-27
申请号：US15542447
申请日：2015-01-26
Applicant: Hitachi High-Technologies Corporation
Inventor： Takayuki OBARA , Muneo MAESHIMA , Kazumichi IMAI , Yohei HANAZAKI
IPC: G01N21/552 , G01N1/38
CPC classification number: G01N21/553 , G01N1/38 , G01N2201/0638 , G01N2201/08
Abstract: This optical analyzing device is provided with a light source, a detector, a substrate having a metal film on at least one surface thereof, and an optical element for introducing a light beam from the light source to the substrate and delivering the light beam from the substrate toward the detector. A plurality of sample regions for holding samples are provided on the metal film; and a portion of the light beam from the light source is irradiated to any one of the sample regions, is reflected, at least once, by the surface of the substrate on the opposite side of the side on which the sample regions are provided, and is not irradiated to a sample region other than the aforementioned sample region in the path thereof until the portion of the light beam is delivered by the optical element.
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公开(公告)号：US20180188181A1
公开(公告)日：2018-07-05
申请号：US15736797
申请日：2016-07-13
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Shunichiro NOBUKI , Muneo MAESHIMA , Kenta IMAI
CPC classification number: G01N21/76 , G01N21/0303 , G01N21/253 , G01N35/1002 , G01N2201/08 , G02B6/0096 , G02B6/4298
Abstract: A highly reflective light-guide system has a highly reflective light-guide surface for reflecting light that has been emitted from a sample and has entered from an entry port opposing a window material and propagating the same to an exit port opposing a light reception surface of a photodetector. An optical filter is provided in a space surrounded by the window material, the photodetector, and the highly reflective light-guide system and transmits the signal luminescence to be measured that is emitted from the sample between the window material and photodetector. The optical filter is fixed to the window material or photodetector by an adhesive, and the peripheral shape of the optical filter is smaller than the shape of the inside of a fitting part to which the optical filter is fitted and that is formed on the highly reflective light-guide system.
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Patent Agency Ranking
公开(公告)号：US20170211032A1
公开(公告)日：2017-07-27
申请号：US15326201
申请日：2015-06-17
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Akira MASUYA , Muneo MAESHIMA , Yasunori SHOJI
Abstract: A temperature regulating container handles multiple samples which can be optically measured in real time while regulating the temperature of the samples. The samples can be moved at high speed by, for example, shaking without requiring a complicated mechanism. A cell culture container is a combination of three kinds of members: a temperature regulating liquid-holding member, a sample-holding member, and a lid. The cell culture container ensures that multiple samples are contacted with a temperature regulating liquid so that the temperature of the samples can be maintained at a uniform temperature, or quickly increased. The lid contacts the surface of the samples, preventing the samples from drying and contamination and, preventing dew formation on an optical path for performing optical measurement. The distance the light passes through the samples can be held constant to thereby assure accurate optical measurement; and sample containers can be easily moved.
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公开(公告)号：US20190033192A1
公开(公告)日：2019-01-31
申请号：US16073009
申请日：2016-12-22
Applicant: Hitachi High-Technologies Corporation
Inventor： Akira MASUYA , Muneo MAESHIMA
Abstract: In the present invention, information is analyzed, the positional relationship of cells/microbes in the optical axis direction is detected, and motility of cells/microbes is evaluated even in an out-of-focus view from an image obtained by a single image capture in an observation view of the cells/microbes. The present invention is provided with an optical system used to measure microparticles present in a sample liquid in a sample container, a drive mechanism for driving the sample container and/or a portion of the optical system in order to three-dimensionally search a bottom surface of the sample container, a control unit for controlling the optical system or the drive mechanism, an image processing unit for dividing an image of microparticles in the sample container at a first time and a second time into an in-focus region and an out-of-focus region and acquiring information relating to the microparticles, and a display unit for displaying the information relating to the microparticles as information representing a temporal change between the first time and the second time.
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公开(公告)号：US20180079996A1
公开(公告)日：2018-03-22
申请号：US15568093
申请日：2016-03-28
Applicant: Hitachi High-Technologies Corporation
Inventor： Hideaki MINEKAWA , Muneo MAESHIMA , Akira MASUYA
Abstract: This sensitivity measuring device is provided with: a stage for placing a sample container; a temperature adjustment device that is provided with an upper heating body and a lower heating body, which are disposed above and below the sample container; and an image pickup device for picking up an image of the sample container, said image pickup device being provided with a lighting apparatus and an image pickup apparatus. Each of the upper heating body and the lower heating body has a structure wherein the temperature of a first region, a peripheral portion, is higher than the temperature of a second region including a center portion.
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公开(公告)号：US20180010084A1
公开(公告)日：2018-01-11
申请号：US15544302
申请日：2016-01-22
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Chihiro UEMATSU , Muneo MAESHIMA
CPC classification number: C12M41/36 , C12M1/34 , C12M23/12 , C12M41/46 , C12Q1/04 , C12Q1/08 , G02B21/26 , G02B21/367 , G02B21/368 , G06T1/00 , G06T7/0016 , G06T2207/10056
Abstract: The invention provides a technology for promptly determining bacterial identification or an antimicrobial susceptibility testing. In the invention, first, a state where the bacteria are divided is monitored by performing microscopic observation with respect to the shape or the number of bacteria in each of wells of a culture plate for bacterial identification culture or the antimicrobial susceptibility testing. In addition, the shape, the number or the area of the bacteria are interpreted from the image obtained by the microscopic observation whether or not the bacteria proliferate at a stage from an induction phase to a logarithmic phase, and the time-dependent changes thereof are made into a graph. From the graph, it is determined whether or not the bacteria proliferate for each measurement, the determination results are displayed on the screen, and accordingly, the result of the antimicrobial susceptibility is provided every time when the measurement is performed (FIG. 12).
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公开(公告)号：US20170096631A1
公开(公告)日：2017-04-06
申请号：US15125980
申请日：2014-09-19
Applicant: Hitachi High-Technologies Corporation
Inventor： Chihiro UEMATSU , Muneo MAESHIMA , Akira MASUYA
IPC: C12M1/34
Abstract: Provided is a test apparatus in which a test for bacterial identification or antimicrobial susceptibility can be promptly determined. A division state of bacteria is monitored by performing microscopic observation of shapes and the number of the bacteria in each of wells in a culture plate for bacterial identification culture or an antimicrobial susceptibility test, and it is determined whether or not the bacteria grow in a stage shifted from an induction phase to a logarithmic phase, with reference to an image obtained through microscopic observation. In addition, determination performed based on turbidity in the related art may be combined with determination performed based on microscopic observation in which change and the like in the shapes of the bacteria are monitored. Accordingly, it is possible to realize a highly accurate test result.
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