公开(公告)号：US20210322336A1

公开(公告)日：2021-10-21

申请号：US17292455

申请日：2019-12-16

Applicant: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Jiangling Wan ,  Han LUO ,  Jianyong SHENG ,  Xiangliang YANG

IPC: A61K9/51 ,  A61K31/337 ,  A61K47/42 ,  A61P35/00

Abstract: A method for preparing albumin nanoparticles based on free radical oxidation, comprising the following steps: preparing albumin aqueous solution with an albumin concentration of 1-20 mg/mL; (2) whilst stirring, adding free radical generating agent to the albumin aqueous solution, and continuing to stir and react for 1-60 min at 15-50° C.; the free radicals generated by the free radical generating agent are used for oxidizing the albumin, and the oxidized albumin molecules assemble to form albumin nanoparticles that are mainly bonded by hydrophobic action, thereby obtaining an albumin nanoparticle suspension. The present invention implements improvement by means of the key reaction mechanism of the nanoparticle preparation method and the corresponding design of the finishing process and, compared to the prior art, can effectively solve the problems of the complexity, high cost, and high toxicity of preparing nanoparticles.

公开(公告)号：US20180272011A1

公开(公告)日：2018-09-27

申请号：US15995111

申请日：2018-05-31

Applicant: Huazhong University of Science and Technology

Inventor： Qibing ZHOU ,  Yushuang WEI ,  Xiangliang YANG

IPC: A61K49/18 ,  A61K49/12

CPC classification number: A61K49/1872 ,  A61K49/12 ,  A61K49/1863 ,  B82Y5/00 ,  B82Y15/00

Abstract: An MRI contrast agent, including superparamagnetic nanoparticles and hydroxyethyl starch. The weight ratio of the superparamagnetic nanoparticles to the hydroxyethyl starch is between 1:5 and 1:15. The superparamagnetic nanoparticles have a particle size of 100-140 nm, and include the following layers, from the inside out, ferrous ferric oxide particles, citric acid, and poly-R-lysine. The citric acid accounts for 6-13 wt. % of the ferrous ferric oxide particles. The poly-R-lysine accounts for 6-20 wt. % of the ferrous ferric oxide particles.

公开(公告)号：US20220133895A1

公开(公告)日：2022-05-05

申请号：US17557008

申请日：2021-12-20

Applicant: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Zifu LI ,  Xiangliang YANG ,  Jiankun GUAN

IPC: A61K47/55 ,  A61K31/4745 ,  A61K47/61 ,  A61K47/59 ,  A61P35/00

Abstract: The disclosure provides a method for removing a cancer tumor stem cell and then further removing a tumor cell and provides an application of a drug molecule and its preparation in tumor treatment or prevention. On the one hand, by inducing the death of immunogenic cells, the anti-tumor immune response is enhanced. On the other hand, indoleamine-2,3-oxygenase is inhibited, immune cells, cytokines, amino acids, etc. are regulated, which improves the niche of cancer stem cells and makes them no longer conducive to the growth of cancer stem cells. Stem cell dormancy is lifted, and the sensitivity of cancer stem cells to chemotherapy drugs and immune cells is enhanced, so that cancer stem cells and tumor cells are effectively killed, and the efficacy of tumor treatment is improved.