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1.发明授权公开(公告)号：US10725052B2
公开(公告)日：2020-07-28
申请号：US15447789
申请日：2017-03-02
Applicant: IDEXX Laboratories, Inc.
Inventor： Mahalakshmi Yerramilli , Giosi Farace , John J. Quinn , Murthy V. S. N. Yerramilli
Abstract: The disclosure provides compositions and methods for the detection of renal disease and periodontal disease in mammals.
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Patent Agency Ranking
公开(公告)号：US09970927B2
公开(公告)日：2018-05-15
申请号：US14192956
申请日：2014-02-28
Applicant: IDEXX Laboratories, Inc.
IPC: G01N33/53 , G01N33/543 , C07C279/12 , C07K16/44 , G01N33/68
CPC classification number: G01N33/53 , C07C279/12 , C07K16/44 , G01N33/54366 , G01N33/6812
Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
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公开(公告)号：US12241900B2
公开(公告)日：2025-03-04
申请号：US18432995
申请日：2024-02-05
Applicant: IDEXX LABORATORIES, INC.
Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
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公开(公告)号：US11933792B2
公开(公告)日：2024-03-19
申请号：US17815765
申请日：2022-07-28
Applicant: IDEXX LABORATORIES, INC.
CPC classification number: G01N33/6893 , G01N33/5308 , G01N33/92 , G01N2800/347 , G01N2800/60
Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
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公开(公告)号：US11435365B2
公开(公告)日：2022-09-06
申请号：US16571345
申请日：2019-09-16
Applicant: IDEXX Laboratories, Inc.
Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
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公开(公告)号：US09091684B2
公开(公告)日：2015-07-28
申请号：US13918531
申请日：2013-06-14
Applicant: IDEXX Laboratories, Inc.
IPC: G01N33/68 , C07K16/44 , G01N33/53 , C07C279/12 , G01N33/543
CPC classification number: G01N33/53 , C07C279/12 , C07K16/44 , G01N33/54366 , G01N33/6812
Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
Abstract translation: 检测生物样品中对称二甲基精氨酸（SDMA）的方法。 SDMA类似物用于产生与不对称的二甲基精氨酸，精氨酸和单甲基精氨酸几乎没有或没有交叉反应性的抗SDMA抗体。 类似物具有受保护或游离的硫醇（-SH）基团或羟基（-OH）基团，其允许它们连接到合适的缀合靶标，其可以是例如含蛋白质的标记分子。 抗SDMA抗体可用于诊断免疫测定以诊断SDMA相关疾病和/或疾病。
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