公开(公告)号：US20190317103A1

公开(公告)日：2019-10-17

申请号：US16314499

申请日：2017-07-26

Applicant: IMRA America, Inc.

Inventor： Andrew A. Mills ,  Kristin B. Cederquist ,  Bing Liu

IPC: G01N33/58 ,  G01N33/53 ,  C22C5/04

Abstract: Disclosed is a method of pulsed laser ablation production of gold-platinum AuxPt1-x alloy nanoparticles in a colloidal solution. The colloidal solution of AuxPt1-x alloy nanoparticles is suitable for many biological applications including lateral flow immunoassays and other bio-detections based on optical scattering. The nanoparticles form by fragmentation of the bulk material without evaporation, minimizing oxidation of the nanoparticles. The nanoparticles conjugate with bio-molecules such as protein, antibodies, peptides, RNA oligomers, DNA oligomers, other oligomers, or polymers effectively by passive adsorption. Advantageously the AuxPt1-x alloy nanoparticles have a wide optical extinction spectrum in the visible region, appearing nearly black in both colloidal and dried form. The nanoparticles can be used for labeling bio-molecules and provide a high visual contrast in visual-based bioassays. A combination of the near black color of the AuxPt1-x alloy nanoparticles with the red color of pure Au nanoparticles makes multiplexing bio-detection assays possible.

公开(公告)号：US20140264031A1

公开(公告)日：2014-09-18

申请号：US14178985

申请日：2014-02-12

Applicant: IMRA AMERICA, INC.

Inventor： Martin E. FERMANN ,  Kevin F. Lee ,  Andrew A. Mills

IPC: G01J3/42 ,  A61B5/00 ,  G01J3/10

CPC classification number: G01J3/42 ,  A61B5/082 ,  A61B5/097 ,  G01J3/453

Abstract: The present invention relates to a trace gas detection system. At least one embodiment includes a frequency spectrum comprising a 1st comb and an enhancement cavity characterized by having a 2nd comb of spectral resonances. The enhancement cavity contains a sample gas for spectroscopic measurement. A dither mechanism is configured to modulate the relative spectral position between the combs at a dither frequency, fd. The dither mechanism, in conjunction with a feedback mechanism, stabilizes the location of said 1st comb lines with respect to the resonances of said 2nd comb over a time scale much greater than a dither period, Td=1/fd. A time-averaged output from the enhancement cavity is provided to a spectroscopic measurement tool, for example a Fourier transform spectrometer. The system is capable of detecting volatile organic compounds, endogenous compounds, and may be configured for cancer detection.

Abstract translation: 痕量气体检测系统技术领域本发明涉及痕量气体检测系统。 至少一个实施例包括包括第一梳状物和增强腔体的频谱，其特征在于具有第二梳状光谱谐振。 增强腔包含用于光谱测量的样品气体。 抖动机构被配置为以抖动频率fd调制梳之间的相对光谱位置。 抖动机构结合反馈机制，稳定了所述第一梳状线相对于所述第二梳状体的谐振在比抖动周期Td = 1 / fd大得多的时间尺度上的位置。 来自增强腔的时间平均输出被提供给光谱测量工具，例如傅里叶变换光谱仪。 该系统能够检测挥发性有机化合物，内源性化合物，并可配置用于癌症检测。