公开(公告)号：US11221339B2

公开(公告)日：2022-01-11

申请号：US16467229

申请日：2017-12-08

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Raghavan Varadarajan ,  Tariq Ahmad Najar ,  Rohini Datta

IPC: C40B30/04 ,  G01N33/68 ,  C12N15/10 ,  C40B40/02

Abstract: The present disclosure provides a rapid, scalable, and high-throughput method of identifying the precise regions in a receptor protein which are involved in binding of a molecule of interest. The method of the instant disclosure is useful where the crystal structure of a protein of interest is not available. Also provided are surface display libraries, and methods of making the same.

公开(公告)号：US20200072850A1

公开(公告)日：2020-03-05

申请号：US16467229

申请日：2017-12-08

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Raghavan Varadarajan ,  Tariq Ahmad Najar ,  Rohini Datta

IPC: G01N33/68 ,  C12N15/10 ,  C40B40/02

Abstract: The present disclosure provides a rapid, scalable, and high-throughput method of identifying the precise regions in a receptor protein which are involved in binding of a molecule of interest. The method of the instant disclosure is useful where the crystal structure of a protein of interest is not available. Also provided are surface display libraries, and methods of making the same.