公开(公告)号：US11938464B2

公开(公告)日：2024-03-26

申请号：US18147894

申请日：2022-12-29

Applicant: JCR Pharmaceuticals Co., Ltd.

Inventor： Tomoki Fukatsu ,  Chika Morooka

IPC: B01D15/18 ,  B01D15/30 ,  B01D15/36 ,  B01J20/283 ,  B01J20/285 ,  B01J20/286 ,  B01J20/32 ,  B01J41/05 ,  B01J41/07 ,  B01J41/14 ,  B01J41/20 ,  C07K16/00 ,  G01N30/06 ,  G01N30/34 ,  G01N30/46 ,  G01N30/74 ,  G01N30/88

CPC classification number: B01J20/283 ,  B01D15/1871 ,  B01D15/305 ,  B01D15/363 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3219 ,  B01J20/3248 ,  B01J41/05 ,  B01J41/07 ,  B01J41/14 ,  B01J41/20 ,  G01N30/06 ,  G01N30/34 ,  G01N30/46 ,  G01N30/461 ,  G01N30/74 ,  G01N30/88 ,  C07K16/00 ,  G01N2030/067 ,  G01N2030/8836

Abstract: A chromatography column for the use of separation of acidic sugar chains, wherein the column comprises a first column and a second column, the second column connected by a flow path downstream of an outlet of the first column, and selected from the following (1) or (2): (1) the carrier of the first column is hydrophobically modified silica having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine; (2) the carrier of the first column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is hydrophobically modified silica having a group containing a primary amine, a secondary amine, or/and a tertiary amine.