公开(公告)号：US20230339836A1

公开(公告)日：2023-10-26

申请号：US17799036

申请日：2021-01-29

Applicant: KANEKA CORPORATION

Inventor： Shiro KITAMURA ,  Koichi KINOSHITA ,  Takahiro UEDA

IPC: C07C50/28

CPC classification number: C07C50/28 ,  C07B2200/13

Abstract: An efficient production method for obtaining a reduced coenzyme Q10 Form II-type crystal having a stable crystal form is disclosed. The production method includes adding a seed crystal of a Form II-type crystal to a solution including ethanol and reduced coenzyme Q10; and precipitating a Form II-type crystal, wherein a dissolved concentration Ci of reduced coenzyme Q10 before adding the seed crystal is equal to or more than a saturated concentration of a Form II-type crystal and less than a saturated concentration of a Form I-type crystal at a temperature Ti when adding the seed crystal. The crystal precipitation step may include controlling a temperature Tp of the solution so that a dissolved concentration Cp of reduced coenzyme Q10 is equal to or more than the saturated concentration of the Form II-type crystal and less than the saturated concentration of the Form I-type crystal.

公开(公告)号：US20210317057A1

公开(公告)日：2021-10-14

申请号：US17271735

申请日：2019-08-29

Applicant: KANEKA CORPORATION

Inventor： Takao YAMAGUCHI ,  Koichi KINOSHITA

IPC: C07C41/40

Abstract: Provided is a production method capable of efficiently producing a reduced coenzyme Q10 Form II crystal. The method for producing a reduced coenzyme Q10 Form II crystal includes: adding a reduced coenzyme Q10 Form II crystal as a seed crystal to a solution with a temperature of 32° C. to 43° C., the solution containing fa) at least one organic solvent selected from the group consisting of an alcohol, a hydrocarbon, an aliphatic acid ester and a nitrogen compound, and (b) reduced coenzyme Q10, to prepare a mixture, and precipitating the reduced coenzyme Q10 from the mixture, in the form of the reduced coenzyme Q10 Form II crystal.