公开(公告)号：US20230339836A1

公开(公告)日：2023-10-26

申请号：US17799036

申请日：2021-01-29

Applicant: KANEKA CORPORATION

Inventor： Shiro KITAMURA ,  Koichi KINOSHITA ,  Takahiro UEDA

IPC: C07C50/28

CPC classification number: C07C50/28 ,  C07B2200/13

Abstract: An efficient production method for obtaining a reduced coenzyme Q10 Form II-type crystal having a stable crystal form is disclosed. The production method includes adding a seed crystal of a Form II-type crystal to a solution including ethanol and reduced coenzyme Q10; and precipitating a Form II-type crystal, wherein a dissolved concentration Ci of reduced coenzyme Q10 before adding the seed crystal is equal to or more than a saturated concentration of a Form II-type crystal and less than a saturated concentration of a Form I-type crystal at a temperature Ti when adding the seed crystal. The crystal precipitation step may include controlling a temperature Tp of the solution so that a dissolved concentration Cp of reduced coenzyme Q10 is equal to or more than the saturated concentration of the Form II-type crystal and less than the saturated concentration of the Form I-type crystal.

公开(公告)号：US20160214919A1

公开(公告)日：2016-07-28

申请号：US15045366

申请日：2016-02-17

Applicant: KANEKA CORPORATION

Inventor： Takashi UEDA ,  Shinsuke AKAO ,  Shiro KITAMURA ,  Hideyuki KISHIDA ,  Takahiro UEDA

IPC: C07C50/28

CPC classification number: C07C50/28 ,  A61K9/0056 ,  A61K9/107 ,  A61K9/1652 ,  A61K9/1664 ,  A61K9/2018 ,  A61K9/4858 ,  A61K9/4875 ,  A61K31/122

Abstract: The present invention provides a particulate composition wherein an oil component containing reduced coenzyme Q10 is polydispersed forming a domain in a matrix containing a water-soluble excipient, which simultaneously shows high oxidative stability and high oral absorbability, a production method thereof, and a stabilizing method thereof. It also provides a food, food with nutrient function claims, food for specified health uses, dietary supplement, nutritional product, animal drug, drink, feed, pet food, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, which contain the composition.

Abstract translation: 本发明提供了一种颗粒组合物，其中含有还原型辅酶Q10的油成分是多分散的，在含有水溶性赋形剂的基质中形成一个结构域，其同时表现出高氧化稳定性和高口服吸收性，其制备方法和稳定化方法 其中。 它还提供食物，具有营养功能的食物，特定健康用途的食物，膳食补充剂，营养产品，动物药物，饮料，饲料，宠物食品，化妆品，药​​物，治疗药物，预防药物等，其含有 组成。