公开(公告)号：US20230339836A1

公开(公告)日：2023-10-26

申请号：US17799036

申请日：2021-01-29

Applicant: KANEKA CORPORATION

Inventor： Shiro KITAMURA ,  Koichi KINOSHITA ,  Takahiro UEDA

IPC: C07C50/28

CPC classification number: C07C50/28 ,  C07B2200/13

Abstract: An efficient production method for obtaining a reduced coenzyme Q10 Form II-type crystal having a stable crystal form is disclosed. The production method includes adding a seed crystal of a Form II-type crystal to a solution including ethanol and reduced coenzyme Q10; and precipitating a Form II-type crystal, wherein a dissolved concentration Ci of reduced coenzyme Q10 before adding the seed crystal is equal to or more than a saturated concentration of a Form II-type crystal and less than a saturated concentration of a Form I-type crystal at a temperature Ti when adding the seed crystal. The crystal precipitation step may include controlling a temperature Tp of the solution so that a dissolved concentration Cp of reduced coenzyme Q10 is equal to or more than the saturated concentration of the Form II-type crystal and less than the saturated concentration of the Form I-type crystal.

公开(公告)号：US20250100959A1

公开(公告)日：2025-03-27

申请号：US18722968

申请日：2022-12-21

Applicant: KANEKA CORPORATION

Inventor： Yuichi YOKOCHI ,  Shiro KITAMURA ,  Yuka FUKUYAMA

IPC: C07C46/10

Abstract: The present description discloses a preferred solution for controlling oxidation of QH without any need for formulation of reduced coenzyme Q10 (QH). One or more embodiments of the present invention relate to a method for storing reduced coenzyme Q10 (QH) or a method for controlling oxidation of QH, the method(s) including storing a composition containing a reduced coenzyme Q10 (QH) and having a water activity at 25° C. of 0.50 or more. One or more other embodiments of the present invention relate to a composition containing QH and having a water activity at 25° C. of 0.50 or more.

公开(公告)号：US20160289152A1

公开(公告)日：2016-10-06

申请号：US15181511

申请日：2016-06-14

Applicant: KANEKA CORPORATION

Inventor： Hideo KAWACHI ,  Shiro KITAMURA ,  Yasuyoshi UEDA

IPC: C07C49/577 ,  A61K31/122 ,  A23L2/52 ,  A61K9/28

CPC classification number: C07C49/577 ,  A23K20/111 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/347 ,  A61K9/28 ,  A61K31/122 ,  A61Q19/00 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23 ,  C07C45/81

Abstract: With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54±2° C. during temperature rise at a rate of 5° C./min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2θ±0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu—Kα) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.

Abstract translation: 关于还原型辅酶Q10，没有关于晶体多晶型的存在的报道，已经认为常规获得的晶体形式仅是一种形式。 本发明涉及在通过差示扫描量热法（DSC）以5℃/ min的速率升温的温度升高期间具有指示在54±2℃熔化的吸热峰的还原型辅酶Q10晶体，和/或还原型 辅酶Q10晶体通过粉末X射线（Cu-Kα）衍射显示衍射角（2θ±0.2°）为11.5°，18.2°，19.3°，22.3°，23.0°和33.3°的特征峰。 晶体形式是在溶剂中具有较高熔点和较低溶解度的新型还原型辅酶Q10晶体，其稳定性优于常规已知的还原型辅酶Q10晶体。

公开(公告)号：US20250082585A1

公开(公告)日：2025-03-13

申请号：US18723030

申请日：2022-12-21

Applicant: KANEKA CORPORATION

Inventor： Yuichi YOKOCHI ,  Shiro KITAMURA ,  Yuka FUKUYAMA

IPC: A61K31/122 ,  A61K9/10

Abstract: The present description discloses a preferred solution for controlling oxidation of reduced coenzyme Q10 (QH) without any need for formulation of QH. One or more embodiments of the present invention relate to a method for storing QH, including storing a composition containing solid QH and water, a method for controlling oxidation of QH, including storing a composition containing solid QH and water, and a liquid composition containing solid QH in water. The solid QH is preferably one or more selected from the group consisting of a Form I crystal, a Form II crystal, an amorphous solid, and a co-crystal composed of QH and one or more other compounds.

公开(公告)号：US20250059124A1

公开(公告)日：2025-02-20

申请号：US18722374

申请日：2022-12-21

Applicant: KANEKA CORPORATION

Inventor： Yuichi YOKOCHI ,  Shiro KITAMURA ,  Yuka FUKUYAMA

IPC: C07C46/10

Abstract: The present description discloses a method for storing reduced coenzyme Q10 (QH), which is capable of controlling oxidation. A first embodiment of the present invention relates to a method for storing QH, including storing a composition containing QH and having a water activity at 25° C. of 0.45 or less. A second embodiment of the present invention relates to a method for controlling oxidation of QH, including storing a composition containing QH and having a water activity at 25° C. of 0.45 or less. A third embodiment of the present invention relates to a composition containing QH and having a water activity at 25° C. of 0.45 or less.

公开(公告)号：US20160214919A1

公开(公告)日：2016-07-28

申请号：US15045366

申请日：2016-02-17

Applicant: KANEKA CORPORATION

Inventor： Takashi UEDA ,  Shinsuke AKAO ,  Shiro KITAMURA ,  Hideyuki KISHIDA ,  Takahiro UEDA

IPC: C07C50/28

CPC classification number: C07C50/28 ,  A61K9/0056 ,  A61K9/107 ,  A61K9/1652 ,  A61K9/1664 ,  A61K9/2018 ,  A61K9/4858 ,  A61K9/4875 ,  A61K31/122

Abstract: The present invention provides a particulate composition wherein an oil component containing reduced coenzyme Q10 is polydispersed forming a domain in a matrix containing a water-soluble excipient, which simultaneously shows high oxidative stability and high oral absorbability, a production method thereof, and a stabilizing method thereof. It also provides a food, food with nutrient function claims, food for specified health uses, dietary supplement, nutritional product, animal drug, drink, feed, pet food, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, which contain the composition.

Abstract translation: 本发明提供了一种颗粒组合物，其中含有还原型辅酶Q10的油成分是多分散的，在含有水溶性赋形剂的基质中形成一个结构域，其同时表现出高氧化稳定性和高口服吸收性，其制备方法和稳定化方法 其中。 它还提供食物，具有营养功能的食物，特定健康用途的食物，膳食补充剂，营养产品，动物药物，饮料，饲料，宠物食品，化妆品，药​​物，治疗药物，预防药物等，其含有 组成。