公开(公告)号：US20210080707A1

公开(公告)日：2021-03-18

申请号：US17105232

申请日：2020-11-25

Applicant: LEICA BIOSYSTEMS IMAGING, INC.

Inventor： Yunlu ZOU ,  Gregory CRANDALL ,  Allen OLSON

IPC: G02B21/00 ,  G02B21/24 ,  G02B21/36

Abstract: Systems and methods for capturing a digital image of a slide using an imaging line sensor and a focusing line sensor. In an embodiment, a beam-splitter is optically coupled to an objective lens and configured to receive one or more images of a portion of a sample through the objective lens. The beam-splitter simultaneously provides a first portion of the one or more images to the focusing sensor and a second portion of the one or more images to the imaging sensor. A processor controls the stage and/or objective lens such that each portion of the one or more images is received by the focusing sensor prior to it being received by the imaging sensor. In this manner, a focus of the objective lens can be controlled using data received from the focusing sensor prior to capturing an image of a portion of the sample using the imaging sensor.

公开(公告)号：US20210048659A1

公开(公告)日：2021-02-18

申请号：US17072785

申请日：2020-10-16

Applicant: LEICA BIOSYSTEMS IMAGING, INC.

Inventor： Yunlu ZOU ,  Nicholas NEWBERG ,  Gregory CRANDALL

IPC: G02B21/36 ,  G02B21/00 ,  G02B21/26 ,  G02B21/34

Abstract: A digital pathology imaging apparatus includes a single line scan camera sensor optically coupled with first and second optical paths. In a first embodiment, transmission mode illumination and oblique mode illumination are simultaneously used during a single stage movement that captures a low resolution macro image of the entire sample area and the entire label area of the slide via the first optical path. In a second embodiment, transmission mode illumination is used during a first stage movement that captures a low resolution macro image of at least the entire sample area via the first optical path and oblique mode illumination is used during a second stage movement that captures a low resolution macro image of at least the entire label area via the first optical path.

公开(公告)号：US20190121108A1

公开(公告)日：2019-04-25

申请号：US16224397

申请日：2018-12-18

Applicant: LEICA BIOSYSTEMS IMAGING, INC.

Inventor： Yunlu ZOU ,  Gregory CRANDALL ,  Allen OLSON

IPC: G02B21/00 ,  G02B21/24 ,  G02B21/36

Abstract: Systems and methods for capturing a digital image of a slide using an imaging line sensor and a focusing line sensor. In an embodiment, a beam-splitter is optically coupled to an objective lens and configured to receive one or more images of a portion of a sample through the objective lens. The beam-splitter simultaneously provides a first portion of the one or more images to the focusing sensor and a second portion of the one or more images to the imaging sensor. A processor controls the stage and/or objective lens such that each portion of the one or more images is received by the focusing sensor prior to it being received by the imaging sensor. In this manner, a focus of the objective lens can be controlled using data received from the focusing sensor prior to capturing an image of a portion of the sample using the imaging sensor.

公开(公告)号：US20180188517A1

公开(公告)日：2018-07-05

申请号：US15858487

申请日：2017-12-29

Applicant: Leica Biosystems Imaging, Inc.

Inventor： Yunlu ZOU ,  Nicholas NEWBERG ,  Gregory CRANDALL

IPC: G02B21/36 ,  G02B21/34 ,  G02B21/00 ,  G02B21/26

CPC classification number: G02B21/361 ,  G02B21/002 ,  G02B21/245 ,  G02B21/26 ,  G02B21/34 ,  G02B21/365 ,  G06T2207/10056

Abstract: A digital pathology imaging apparatus includes a single line scan camera sensor optically coupled with first and second optical paths. In a first embodiment, transmission mode illumination and oblique mode illumination are simultaneously used during a single stage movement that captures a low resolution macro image of the entire sample area and the entire label area of the slide via the first optical path. In a second embodiment, transmission mode illumination is used during a first stage movement that captures a low resolution macro image of at least the entire sample area via the first optical path and oblique mode illumination is used during a second stage movement that captures a low resolution macro image of at least the entire label area via the first optical path.

公开(公告)号：US20200026056A1

公开(公告)日：2020-01-23

申请号：US16557623

申请日：2019-08-30

Applicant: Leica Biosystems Imaging, Inc.

Inventor： Yunlu ZOU ,  Nicholas NEWBERG ,  Gregory CRANDALL

IPC: G02B21/36 ,  G02B21/00 ,  G02B21/26 ,  G02B21/34

Abstract: A digital pathology imaging apparatus includes a single line scan camera sensor optically coupled with first and second optical paths. In a first embodiment, transmission mode illumination and oblique mode illumination are simultaneously used during a single stage movement that captures a low resolution macro image of the entire sample area and the entire label area of the slide via the first optical path. In a second embodiment, transmission mode illumination is used during a first stage movement that captures a low resolution macro image of at least the entire sample area via the first optical path and oblique mode illumination is used during a second stage movement that captures a low resolution macro image of at least the entire label area via the first optical path.

公开(公告)号：US20180100997A1

公开(公告)日：2018-04-12

申请号：US15838043

申请日：2017-12-11

Applicant: Leica Biosystems Imaging, Inc.

Inventor： Yunlu ZOU ,  Gregory CRANDALL ,  Allen OLSON

IPC: G02B21/00 ,  G02B21/36 ,  G02B21/24

CPC classification number: G02B21/006 ,  G02B21/245 ,  G02B21/361 ,  G02B21/365

Abstract: Systems and methods for capturing a digital image of a slide using an imaging line sensor and a focusing line sensor. In an embodiment, a beam-splitter is optically coupled to an objective lens and configured to receive one or more images of a portion of a sample through the objective lens. The beam-splitter simultaneously provides a first portion of the one or more images to the focusing sensor and a second portion of the one or more images to the imaging sensor. A processor controls the stage and/or objective lens such that each portion of the one or more images is received by the focusing sensor prior to it being received by the imaging sensor. In this manner, a focus of the objective lens can be controlled using data received from the focusing sensor prior to capturing an image of a portion of the sample using the imaging sensor.