公开(公告)号：US20170038331A1

公开(公告)日：2017-02-09

申请号：US14818345

申请日：2015-08-05

Applicant: LifeScan Scotland Limited

Inventor： Gavin MACFIE ,  David MCCOLL

IPC: G01N27/327

CPC classification number: G01N27/3274 ,  G01N27/3272 ,  G01N27/3273

Abstract: A system and a method for correcting an analyte concentration measurement taken by a test strip is described herein. The test strip includes at least two spaced apart electrodes defining an electrochemical cell or reaction chamber. An initial polarization parameter of the test strip is determined at the time of test strip manufacture and a testing polarization parameter is determined at the time of testing. A resulting correction factor is then determined based on the initial and testing polarization parameters. The correction parameter can be applied to a measured analyte concentration in order to correct the measured analyte concentration.

Abstract translation: 本文描述了用于校正由测试条进行的分析物浓度测量的系统和方法。 测试条包括限定电化学电池或反应室的至少两个间隔开的电极。 在测试条制造时确定测试条的初始极化参数，并且在测试时确定测试偏振参数。 然后基于初始和测试偏振参数确定产生的校正因子。 校正参数可以应用于测量的分析物浓度，以便校正测得的分析物浓度。

公开(公告)号：US20160187283A1

公开(公告)日：2016-06-30

申请号：US14892666

申请日：2014-06-06

Applicant: LIFESCAN SCOTLAND LIMITED

Inventor： Alexander COOPER ,  James Iain RODGERS ,  Gavin MACFIE

IPC: G01N27/327 ,  C12Q1/00

CPC classification number: G01N27/3272 ,  C12Q1/001 ,  C12Q1/004

Abstract: Electrochemical-based analytical test strip with a soluble electrochemically-active coating opposite a bare electrode An electrochemical-based analytical test strip (EBATS) for the determination of an analyte in a bodily fluid sample includes an electrically insulating base layer, a patterned electrically conductive layer disposed on the electrically insulating base layer and including a plurality of electrodes, and an enzymatic reagent layer disposed on a portion of the patterned conductor layer and defining a bare electrode(s) and a plurality of enzymatic reagent covered electrodes from the plurality of electrodes. The EBATS also includes a patterned spacer layer, a top layer having an underside surface (USS), and a soluble electrochemically-active coating (SEAC) disposed on the USS of the top layer. In addition, at least the patterned spacer layer and top layer define a sample-receiving chamber within the EBATS. Furthermore, the SEAC is disposed on the USS of the top layer within at least a portion the sample-receiving chamber and in an opposing relationship to the bare electrodes.

Abstract translation: 具有与裸露电极相对的可溶电化学活性涂层的基于电化学的分析测试条用于测定体液样品中的分析物的基于电化学的分析测试条（EBATS）包括电绝缘基底层，图案化导电层 设置在所述电绝缘基底层上并且包括多个电极，以及设置在所述图案化导体层的一部分上并且从所述多个电极限定裸电极和多个酶试剂覆盖电极的酶试剂层。 EBATS还包括图案化间隔层，具有下表面（USS）的顶层和设置在顶层的USS上的可溶电化学活性涂层（SEAC）。 此外，至少图案化间隔层和顶层限定EBATS内的样品接收室。 此外，SEAC设置在至少部分样品接收室内的顶层的USS上，并且与裸露电极相对的关系。

公开(公告)号：US20160017399A1

公开(公告)日：2016-01-21

申请号：US14333552

申请日：2014-07-17

Applicant: LifeScan Scotland Limited

Inventor： Marco CARDOSI ,  Rebecca PHILLIPS ,  Gavin MACFIE

IPC: C12Q1/00 ,  G01N27/327

CPC classification number: C12Q1/006 ,  C12Q1/004 ,  G01N27/327

Abstract: An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample includes an electrically insulating base layer, an electrically conductive layer disposed on the electrically insulating base layer and including at least one electrode, an enzymatic reagent layer disposed on the at least one electrode, a patterned spacer layer, and a top layer. Moreover, the enzymatic reagent layer includes at least one naphthoquinone-based mediator. The naphthoquinone-based mediator can, for example, be at least one of 1,2-naphthalenedione-4-(3-mercapto-1-propane sulfonic acid) and 1,2-naphthalenedione-4-(3-mercaptopropionic acid); and FAD-GDH enzyme.

Abstract translation: 用于测定体液样品中的分析物（例如葡萄糖）的基于电化学的分析测试条包括电绝缘基底层，设置在电绝缘基底层上的导电层，并且包括至少一个电极，酶 设置在至少一个电极上的试剂层，图案化间隔层和顶层。 此外，酶试剂层包括至少一种基于萘醌的介体。 基于萘醌的介体可以是例如1,2-萘二酮-4-（3-巯基-1-丙烷磺酸）和1,2-萘二酮-4-（3-巯基丙酸）中的至少一种; 和FAD-GDH酶。

公开(公告)号：US20150362453A1

公开(公告)日：2015-12-17

申请号：US14764427

申请日：2014-01-30

Applicant: LIFESCAN SCOTLAND LIMITED

Inventor： Gavin MACFIE ,  Alexander COOPER ,  Christopher LEACH ,  Stephen MACKINTOSH

IPC: G01N27/327

CPC classification number: G01N27/3272 ,  C12Q1/001 ,  G01N27/3271

Abstract: An electrochemical-based analytical test strip (EBATS) for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes an electrically insulating base layer (110), a patterned electrically conductive layer (120) disposed on the electrically insulating base layer, an enzymatic reagent layer (140) disposed on the patterned electrically conductor layer, a patterned spacer layer (150), a top layer (170) having an underside surface, and a soluble acidic material coating (160) on the underside surface of the top layer. The patterned spacer layer and top layer define a sample-receiving chamber (180) within the EBATS and the soluble acidic material coating is disposed on the underside surface of the top layer within the sample-receiving chamber. In addition, the soluble acidic material coating is operably dissolvable in the bodily fluid sample such that a pH of the bodily fluid sample in the sample-receiving chamber is reduced during use of the EBATS.

Abstract translation: 用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的基于电化学的分析测试条（EBATS）包括电绝缘基底层（110），图案化导电层 （120），设置在图案化导电体层上的酶试剂层（140），图案化间隔层（150），具有下表面的顶层（170）和可溶性酸性物质 在顶层的下表面上涂覆（160）。 图案化间隔层和顶层限定EBATS内的样品接收室（180），并且可溶性酸性材料涂层设置在样品接收室内的顶层的下表面上。 此外，可溶性酸性材料涂层可操作地溶解在体液样品中，使得在使用EBATS期间样品接收室中的体液样品的pH降低。