公开(公告)号：US20160017399A1

公开(公告)日：2016-01-21

申请号：US14333552

申请日：2014-07-17

Applicant: LifeScan Scotland Limited

Inventor： Marco CARDOSI ,  Rebecca PHILLIPS ,  Gavin MACFIE

IPC: C12Q1/00 ,  G01N27/327

CPC classification number: C12Q1/006 ,  C12Q1/004 ,  G01N27/327

Abstract: An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample includes an electrically insulating base layer, an electrically conductive layer disposed on the electrically insulating base layer and including at least one electrode, an enzymatic reagent layer disposed on the at least one electrode, a patterned spacer layer, and a top layer. Moreover, the enzymatic reagent layer includes at least one naphthoquinone-based mediator. The naphthoquinone-based mediator can, for example, be at least one of 1,2-naphthalenedione-4-(3-mercapto-1-propane sulfonic acid) and 1,2-naphthalenedione-4-(3-mercaptopropionic acid); and FAD-GDH enzyme.

Abstract translation: 用于测定体液样品中的分析物（例如葡萄糖）的基于电化学的分析测试条包括电绝缘基底层，设置在电绝缘基底层上的导电层，并且包括至少一个电极，酶 设置在至少一个电极上的试剂层，图案化间隔层和顶层。 此外，酶试剂层包括至少一种基于萘醌的介体。 基于萘醌的介体可以是例如1,2-萘二酮-4-（3-巯基-1-丙烷磺酸）和1,2-萘二酮-4-（3-巯基丙酸）中的至少一种; 和FAD-GDH酶。