公开(公告)号：US20240018607A1

公开(公告)日：2024-01-18

申请号：US18252869

申请日：2021-11-12

Applicant: LogicInk Corporation

Inventor： Carlos Edel OLGUIN ALVAREZ ,  Hendrik DIETZ ,  Steven WROBEL

IPC: C12Q1/6897 ,  C12Q1/44

CPC classification number: C12Q1/6897 ,  C12Q1/44

Abstract: Systems comprising a translation module, an amplification module comprising one or more sensing modalities, and a detection module configured to accept the amplifier output and methods of using the same are provided. The systems or methods can be capable of detecting trace amounts of nucleic acid molecules with high sensitivity and specificity in a device-free system with naked-eye readable output. The systems can comprise three layers incorporated into a lateral flow assay and/or a paper strip assay, in such systems, the first layer can comprise the translation module, the second layer can comprise the amplification module, and the third layer can comprise the detection module.

公开(公告)号：US20210333214A1

公开(公告)日：2021-10-28

申请号：US17219527

申请日：2021-03-31

Applicant: LogicInk Corporation

Inventor： Carlos Edel OLGUIN ALVAREZ ,  Steven WROBEL ,  Hendrik DIETZ

IPC: G01N21/78 ,  G01N27/414 ,  G01N21/27

Abstract: Systems and indicators for determining the presence or absence of specific environmental, exposure, or biological conditions are provided. Indicators include a plurality of sensors, each sensor independently having a biological or chemical sensing modality to detect one or more analytes of interest. Analytes of interest include nucleic acids (e.g., DNA, RNA, etc.), proteins, peptides, and other amino acid chains and may come from a subject or the microbiome of a subject. The signals from the plurality of sensors may be processed to provide a readily understandable readout concerning a health condition or predisposition of a subject, such as cancer and exposure to coronavirus. The signals from the plurality of sensors may be colorimetric (e.g. a color change in response to the presence or absence of an analyte), and a plurality of colorimetric signals may be combined to provide a readily understandable colorimetric output. Indicators may be wearable.

公开(公告)号：US20250146947A1

公开(公告)日：2025-05-08

申请号：US18740134

申请日：2024-06-11

Applicant: LogicInk Corporation

Inventor： Carlos Edel OLGUIN ALVAREZ ,  Steven WROBEL ,  Hendrik DIETZ

IPC: G01N21/78 ,  G01N21/27 ,  G01N21/77 ,  G01N27/414

Abstract: Systems and indicators for determining the presence or absence of specific environmental, exposure, or biological conditions are provided. Indicators include a plurality of sensors, each sensor independently having a biological or chemical sensing modality to detect one or more analytes of interest. Analytes of interest include nucleic acids (e.g., DNA, RNA, etc.), proteins, peptides, and other amino acid chains and may come from a subject or the microbiome of a subject. The signals from the plurality of sensors may be processed to provide a readily understandable readout concerning a health condition or predisposition of a subject, such as cancer and exposure to coronavirus. The signals from the plurality of sensors may be colorimetric (e.g. a color change in response to the presence or absence of an analyte), and a plurality of colorimetric signals may be combined to provide a readily understandable colorimetric output. Indicators may be wearable.

公开(公告)号：US20230212702A1

公开(公告)日：2023-07-06

申请号：US18000615

申请日：2021-06-04

Applicant: LogicInk Corporation

Inventor： Hendrik DIETZ ,  Carlos Edel OLGUIN ALVAREZ

IPC: C12Q1/70 ,  C12Q1/6818

CPC classification number: C12Q1/701 ,  C12Q1/6818

Abstract: Systems and methods for determining the presence or absence of an analyte including a nucleic acid (e.g., DNA and RNA), a small molecule (e.g., proteins and amino acid chains), and one or more electrolytes (e.g., Na+ and K+). The system or method may detect multiple analytes (e.g., a first DNA and a second DNA) and/or multiple types of analytes (e.g., an RNA and an antibody protein). The signal readout provided by the system or method may be readily understood and may be correlated with a health condition (e.g., hydration or exposure to an infectious agent). The system may be wearable and may analyze one or more biofluids.