公开(公告)号：US10883923B2

公开(公告)日：2021-01-05

申请号：US15996011

申请日：2018-06-01

Applicant: M.I.S. Electronics Inc.

Inventor： Mohammad E Khosroshahi

IPC: G01N21/17 ,  G01N33/49 ,  G01N21/64 ,  G01N33/543 ,  G01N29/46 ,  G01L1/24 ,  G01N33/553 ,  G01N29/24

Abstract: This invention relates a biomarker detection system, for detecting cancer biomarkers using optical heterodyning. The system includes a tunable laser configured to produce a plurality of laser beams of at least two frequencies, a pair of optical fibers coated with gold nanoparticles and functionalized with an antibody is configured to undergo a change of fiber surface of each optical fiber by adsorbing molecules of an analyte on a surface of the antibody, modify a reflection of the plurality of laser beams inside a fiber core of the each optical fiber when the each optical fiber is bent, and create an audible beat frequency; and perform spectral analysis. A frequency spectrum analyzer configured to provide a composition information of the adsorbed molecules based on a spectral analysis of the beat frequency.

公开(公告)号：US20230168239A1

公开(公告)日：2023-06-01

申请号：US17536017

申请日：2021-11-27

Applicant: M.I.S. Electronics Inc.

Inventor： Mohammad E Khosroshahi ,  Yesha Patel

IPC: G01N33/49 ,  G01N21/65 ,  G01N21/64 ,  G01N21/31

CPC classification number: G01N33/49 ,  G01N21/658 ,  G01N21/6486 ,  G01N21/31 ,  G01N2201/08 ,  G01N2201/061

Abstract: An optical multimodal detection system for targeted detection of cancer biomarkers in blood serum. The system comprises of a nano-biosensor, a chamber for receiving the nano-biosensor, a localized surface plasmon resonance (LSPR) based detector, a plasmon enhanced fluorescence (PEF) based detector and a surface-enhanced Raman scattering (SERS) based detector. The nano-biosensor comprises of a glass substrate provided with an active site for receiving a sample of blood serum, and is dimensioned to define a flow channel for introducing the sample of blood serum into the nano-biosensor. The nano-biosensor is provided with a layer of amino-silane compound coating over the glass substrate and a plurality of gold nano-urchins (GNU) bound to the layer of silicone compound. The plurality of gold-nano-urchins are functionalized with a hydrazide linker molecule for allowing uniform-oriented conjugation of a Fc region of antibodies to a surface of gold nano-urchins thereby allowing Fab regions of antibodies for binding with cancer biomarkers.

公开(公告)号：US11828747B2

公开(公告)日：2023-11-28

申请号：US17536017

申请日：2021-11-27

Applicant: M.I.S. Electronics Inc.

Inventor： Mohammad E Khosroshahi ,  Yesha Patel

IPC: G01N33/49 ,  G01N21/65 ,  G01N21/31 ,  G01N21/64

CPC classification number: G01N33/49 ,  G01N21/31 ,  G01N21/6486 ,  G01N21/658 ,  G01N2201/061 ,  G01N2201/08

Abstract: An optical multimodal detection system for targeted detection of cancer biomarkers in blood serum. The system comprises of a nano-biosensor, a chamber for receiving the nano-biosensor, a localized surface plasmon resonance (LSPR) based detector, a plasmon enhanced fluorescence (PEF) based detector and a surface-enhanced Raman scattering (SERS) based detector. The nano-biosensor comprises of a glass substrate provided with an active site for receiving a sample of blood serum, and is dimensioned to define a flow channel for introducing the sample of blood serum into the nano-biosensor. The nano-biosensor is provided with a layer of amino-silane compound coating over the glass substrate and a plurality of gold nano-urchins (GNU) bound to the layer of silicone compound. The plurality of gold-nano-urchins are functionalized with a hydrazide linker molecule for allowing uniform-oriented conjugation of a Fc region of antibodies to a surface of gold nano-urchins thereby allowing Fab regions of antibodies for binding with cancer biomarkers.

公开(公告)号：US20220117905A1

公开(公告)日：2022-04-21

申请号：US17233469

申请日：2021-04-17

Applicant: M.I.S. Electronics Inc.

Inventor： Mohammad E Khosroshahi ,  Vaughn Woll-Morison ,  Tiam Mohmedi

IPC: A61K9/51 ,  C12N1/14 ,  A61K49/00

Abstract: A method for fabricating a nanostructure comprises adding a fungal mycelium (114) in a growth vessel (110). The growth vessel (110) comprising a growth medium (118). In the next step, the nanostructure is added in the growth vessel (110) which is then absorbed by the fungal mycelium (114) and finally distributed throughout the fungal mycelium (114). Further, a delivery vehicle for payload (206) is also disclosed which comprises the fabricated nanostructure.