公开(公告)号：US20180011072A1

公开(公告)日：2018-01-11

申请号：US15615802

申请日：2017-06-06

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Michael S. Strano ,  Daniel A. Heller ,  George W. Pratt ,  Jingqing Zhang

IPC: G01N33/22 ,  B82Y30/00 ,  G01N21/64

CPC classification number: G01N33/227 ,  B82Y30/00 ,  G01N21/6428 ,  G01N21/643 ,  G01N21/6489 ,  G01N2201/061 ,  G01N2201/068

Abstract: Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described.

公开(公告)号：US10338051B2

公开(公告)日：2019-07-02

申请号：US15615802

申请日：2017-06-06

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Michael S. Strano ,  Daniel A. Heller ,  George W. Pratt ,  Jingqing Zhang

IPC: G01N33/22 ,  B82Y30/00 ,  G01N21/64

Abstract: Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described.

公开(公告)号：US20160178597A1

公开(公告)日：2016-06-23

申请号：US13914236

申请日：2013-06-10

Applicant: Massachusetts Institute of Technology

Inventor： Michael S. Strano ,  Daniel A. Heller ,  George W. Pratt ,  Jingqing Zhang

IPC: G01N33/22 ,  G01N21/64

CPC classification number: G01N33/227 ,  B82Y30/00 ,  G01N21/6428 ,  G01N21/643 ,  G01N21/6489 ,  G01N2201/061 ,  G01N2201/068

Abstract: Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described.

Abstract translation: 通常描述与包含光致发光纳米结构的光学纳米传感器有关的系统和方法。

公开(公告)号：US20140220346A1

公开(公告)日：2014-08-07

申请号：US14097212

申请日：2013-12-04

Applicant: Memorial Sloan-Kettering Cancer Center ,  Massachusetts Institute of Technology

Inventor： Daniel A. Heller ,  Jasmine Wallas ,  Yair Levi ,  George W. Pratt ,  Daniel G. Anderson ,  Robert Langer

IPC: A61K47/48 ,  A61K49/00

CPC classification number: A61K49/0073 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0054 ,  A61K51/065 ,  A61K51/1213 ,  Y10T428/2982

Abstract: In certain embodiments, a nano-sized vehicle (e.g., a nanogel comprising nanoparticles) is provided herein for drug delivery with tunable biodistribution, low toxicity, and degradability, and with demonstrated targeting to bone. The composition is useful, for example, in the treatment of bone disease, particularly bone metastases from cancers such as breast, prostate, or lung cancer.

Abstract translation: 在某些实施方案中，本文提供了纳米级载体（例如，包含纳米颗粒的纳米凝胶）用于具有可调节的生物分布，低毒性和降解性的药物递送，并且已经证实靶向骨。 该组合物可用于例如治疗骨疾病，特别是来自癌症如乳腺癌，前列腺癌或肺癌的骨转移瘤。