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    DRUG TREATMENT OF OVERACTIVE BLADDER
    1.
    发明申请
    DRUG TREATMENT OF OVERACTIVE BLADDER 有权
    过敏刀片的药物治疗

    公开(公告)号：US20160375003A1

    公开(公告)日：2016-12-29

    申请号：US15207718

    申请日：2016-07-12

    Applicant: Michael E. DiSanto

    Inventor： Michael E. DiSanto

    IPC: A61K31/4745 ,  A61K45/06

    CPC classification number: A61K31/4745 ,  A45C5/03 ,  A45C5/14 ,  A45C9/00 ,  A61K45/06 ,  H03L1/026 ,  H04B1/16

    Abstract: Provided are methods of treating an overactive bladder in a patient which include: administering a Myosin II ATPase inhibitor compound; or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3b] quinolin-4-one) compound of Formula 1 or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3b] quinolin-4-one) compound of Formula II; or administering pharmaceutically-acceptable salts, racemic mixtures, enantiomers, or prodrugs of said compounds, useful in their active form as inhibitors of Myosin II ATPase related to over-active bladder. Optionally the compounds are administered intervesicularly into the bladder. Also provided are pharmaceutical compositions comprising said compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder related to inhibition of Myosin II ATPase. These pharmaceutical compositions also may contain one or more other compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder.

    Abstract translation: 提供治疗患者膀胱过度活动的方法，其包括：施用肌球蛋白II ATP酶抑制剂化合物; 或施用式1的X基和Y基取代的（3a-羟基-1-苯基-1,2,3,3a-四氢-4H-吡咯并[2,3-b]喹啉-4-酮）化合物或施用X 基团和Y基取代的（3a-羟基-1-苯基-1,2,3,3a-四氢-4H-吡咯并[2,3-b]喹啉-4-酮）化合物; 或施用所述化合物的药学上可接受的盐，外消旋混合物，对映异构体或前药，其活性形式可用作与过活动性膀胱相关的肌球蛋白II ATP酶的抑制剂。 任选地，化合物被间质地施用到膀胱中。 还提供了包含可用于其活性形式的所述化合物的药物组合物作为治疗患有与抑制肌球蛋白II ATP酶相关的过度膀胱的患者的方法。 这些药物组合物还可以含有一种或多种其它有效形式的其它化合物作为治疗患有过度​​活动性膀胱的患者的方法。

    DRUG TREATMENT OF OVERACTIVE BLADDER
    3.
    发明申请
    DRUG TREATMENT OF OVERACTIVE BLADDER 有权
    过敏刀片的药物治疗

    公开(公告)号：US20140200238A1

    公开(公告)日：2014-07-17

    申请号：US14118448

    申请日：2012-05-17

    Applicant: Michael E. DiSanto

    Inventor： Michael E. DiSanto

    IPC: A61K31/4745 ,  A61K45/06

    CPC classification number: A61K31/4745 ,  A45C5/03 ,  A45C5/14 ,  A45C9/00 ,  A61K45/06 ,  H03L1/026 ,  H04B1/16

    Abstract: Provided are methods of treating an overactive bladder in a patient which include: administering a Myosin II ATPase inhibitor compound; or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrollo[2, 3b] quinolin-4-one) compound of Formula 1 or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrollo[2,3b] quinolin-4-one) compound of Formula II; or administering pharmaceutically-acceptable salts, racemic mixtures, enantiomers, or prodrugs of said compounds, useful in their active form as inhibitors of Myosin H ATPase related to over-active bladder. Optionally the compounds are administered intervesicularly into the bladder. Also provided are pharmaceutical compositions comprising said compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder related to inhibition of Myosin II ATPase. These pharmaceutical compositions also may contain one or more other compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder.

    Abstract translation: 提供治疗患者膀胱过度活动的方法，其包括：施用肌球蛋白II ATP酶抑制剂化合物; 或给予式1的X基和Y基取代的（3a-羟基-1-苯基-1,2,3,3a-四氢-4H-吡咯并[2,3,3喹啉-4-酮）化合物或施用X 基团和Y基取代的（3a-羟基-1-苯基-1,2,3,3a-四氢-4H-吡咯并[2,3b]喹啉-4-酮）化合物; 或施用所述化合物的药学上可接受的盐，外消旋混合物，对映异构体或前药，其活性形式可用作与过活动性膀胱相关的肌球蛋白H ATP酶的抑制剂。 任选地，化合物被间质地施用到膀胱中。 还提供了包含可用于其活性形式的所述化合物的药物组合物作为治疗患有与抑制肌球蛋白II ATP酶相关的过度膀胱的患者的方法。 这些药物组合物还可以含有一种或多种其它有效形式的其它化合物作为治疗患有过度​​活动性膀胱的患者的方法。

    Drug treatment of overactive bladder
    4.
    发明授权
    Drug treatment of overactive bladder 有权

    公开(公告)号：US09943512B2

    公开(公告)日：2018-04-17

    申请号：US15207718

    申请日：2016-07-12

    Applicant: Michael E. DiSanto

    Inventor： Michael E. DiSanto

    IPC: A61K45/06 ,  A45C9/00 ,  A45C5/14 ,  A61K31/4745 ,  H03L1/02 ,  H04B1/16 ,  A45C5/03

    CPC classification number: A61K31/4745 ,  A45C5/03 ,  A45C5/14 ,  A45C9/00 ,  A61K45/06 ,  H03L1/026 ,  H04B1/16

    Abstract: Provided are methods of treating an overactive bladder in a patient which include: administering a Myosin II ATPase inhibitor compound; or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3b] quinolin-4-one) compound of Formula 1 or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3b] quinolin-4-one) compound of Formula II; or administering pharmaceutically-acceptable salts, racemic mixtures, enantiomers, or prodrugs of said compounds, useful in their active form as inhibitors of Myosin II ATPase related to over-active bladder. Optionally the compounds are administered intervesicularly into the bladder. Also provided are pharmaceutical compositions comprising said compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder related to inhibition of Myosin II ATPase. These pharmaceutical compositions also may contain one or more other compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder.

    Drug treatment of overactive bladder
    5.
    发明授权
    Drug treatment of overactive bladder 有权
    药物治疗膀胱过动症

    公开(公告)号：US09492441B2

    公开(公告)日：2016-11-15

    申请号：US14118448

    申请日：2012-05-17

    Applicant: Michael E. DiSanto

    Inventor： Michael E. DiSanto

    IPC: A61K45/06 ,  A61K31/4745 ,  H04B1/16 ,  H03L1/02

    CPC classification number: A61K31/4745 ,  A45C5/03 ,  A45C5/14 ,  A45C9/00 ,  A61K45/06 ,  H03L1/026 ,  H04B1/16

    Abstract: Provided are methods of treating an overactive bladder in a patient which include: administering a Myosin II ATPase inhibitor compound; or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3b]quinolin-4-one) compound of Formula 1 or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3b]quinolin-4-one) compound of Formula II; or administering pharmaceutically-acceptable salts, racemic mixtures, enantiomers, or prodrugs of said compounds, useful in their active form as inhibitors of Myosin H ATPase related to over-active bladder. Optionally the compounds are administered intervesicularly into the bladder. Also provided are pharmaceutical compositions comprising said compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder related to inhibition of Myosin II ATPase. These pharmaceutical compositions also may contain one or more other compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder.

    Abstract translation: 提供治疗患者膀胱过度活动的方法，其包括：施用肌球蛋白II ATP酶抑制剂化合物; 或施用式1的X基和Y基取代的（3a-羟基-1-苯基-1,2,3,3a-四氢-4H-吡咯并[2,3-b]喹啉-4-酮）化合物或施用X 基团和Y基取代的（3a-羟基-1-苯基-1,2,3,3a-四氢-4H-吡咯并[2,3-b]喹啉-4-酮）化合物; 或施用所述化合物的药学上可接受的盐，外消旋混合物，对映异构体或前药，其活性形式可用作与过活动性膀胱相关的肌球蛋白H ATP酶的抑制剂。 任选地，化合物被间质地施用到膀胱中。 还提供了包含可用于其活性形式的所述化合物的药物组合物作为治疗患有与抑制肌球蛋白II ATP酶相关的过度膀胱的患者的方法。 这些药物组合物还可以含有一种或多种其它有效形式的其它化合物作为治疗患有过度​​活动性膀胱的患者的方法。

    Drug treatment of overactive bladder
    7.
    发明授权
    Drug treatment of overactive bladder 有权

    公开(公告)号：US09827238B2

    公开(公告)日：2017-11-28

    申请号：US15209205

    申请日：2016-07-13

    Applicant: Michael E. DiSanto

    Inventor： Michael E. DiSanto

    IPC: A61K45/06 ,  A45C5/14 ,  A45C9/00 ,  A61K31/4745 ,  H03L1/02 ,  H04B1/16 ,  A45C5/03

    CPC classification number: A61K31/4745 ,  A45C5/03 ,  A45C5/14 ,  A45C9/00 ,  A61K45/06 ,  H03L1/026 ,  H04B1/16

    Abstract: Provided are methods of treating an overactive bladder in a patient which include: administering a Myosin II ATPase inhibitor compound; or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrollo[2,3b] quinolin-4-one) compound of Formula 1 or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrollo[2,3b] quinolin-4-one) compound of Formula II; or administering pharmaceutically-acceptable salts, racemic mixtures, enantiomers, or prodrugs of said compounds, useful in their active form as inhibitors of Myosin II ATPase related to over-active bladder. Optionally the compounds are administered intervesicularly into the bladder. Also provided are pharmaceutical compositions comprising said compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder related to inhibition of Myosin II ATPase. These pharmaceutical compositions also may contain one or more other compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder.

    DRUG TREATMENT OF OVERACTIVE BLADDER
    8.
    发明申请
    DRUG TREATMENT OF OVERACTIVE BLADDER 有权
    过敏刀片的药物治疗

    公开(公告)号：US20170020861A1

    公开(公告)日：2017-01-26

    申请号：US15209205

    申请日：2016-07-13

    Applicant: Michael E. DiSanto

    Inventor： Michael E. DiSanto

    IPC: A61K31/4745 ,  A61K45/06

    CPC classification number: A61K31/4745 ,  A45C5/03 ,  A45C5/14 ,  A45C9/00 ,  A61K45/06 ,  H03L1/026 ,  H04B1/16

    Abstract: Provided are methods of treating an overactive bladder in a patient which include: administering a Myosin II ATPase inhibitor compound; or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrollo[2,3b] quinolin-4-one) compound of Formula 1 or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrollo[2,3b] quinolin-4-one) compound of Formula II; or administering pharmaceutically-acceptable salts, racemic mixtures, enantiomers, or prodrugs of said compounds, useful in their active form as inhibitors of Myosin II ATPase related to over-active bladder. Optionally the compounds are administered intervesicularly into the bladder. Also provided are pharmaceutical compositions comprising said compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder related to inhibition of Myosin II ATPase. These pharmaceutical compositions also may contain one or more other compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder.

    Abstract translation: 提供治疗患者膀胱过度活动的方法，其包括：施用肌球蛋白II ATP酶抑制剂化合物; 或施用式1的X基和Y基取代的（3a-羟基-1-苯基-1,2,3,3a-四氢-4H-吡咯并[2,3b]喹啉-4-酮）化合物或施用X 基团和Y基取代的（3a-羟基-1-苯基-1,2,3,3a-四氢-4H-吡咯并[2,3b]喹啉-4-酮）化合物; 或施用所述化合物的药学上可接受的盐，外消旋混合物，对映异构体或前药，其活性形式可用作与过活动性膀胱相关的肌球蛋白II ATP酶的抑制剂。 任选地，化合物被间质地施用到膀胱中。 还提供了包含可用于其活性形式的所述化合物的药物组合物作为治疗患有与抑制肌球蛋白II ATP酶相关的过度膀胱的患者的方法。 这些药物组合物还可以含有一种或多种其它有效形式的其它化合物作为治疗患有过度​​活动性膀胱的患者的方法。

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