Drug treatment of overactive bladder

    公开(公告)号:US09943512B2

    公开(公告)日:2018-04-17

    申请号:US15207718

    申请日:2016-07-12

    Abstract: Provided are methods of treating an overactive bladder in a patient which include: administering a Myosin II ATPase inhibitor compound; or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3b] quinolin-4-one) compound of Formula 1 or administering an X group and Y group substituted (3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3b] quinolin-4-one) compound of Formula II; or administering pharmaceutically-acceptable salts, racemic mixtures, enantiomers, or prodrugs of said compounds, useful in their active form as inhibitors of Myosin II ATPase related to over-active bladder. Optionally the compounds are administered intervesicularly into the bladder. Also provided are pharmaceutical compositions comprising said compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder related to inhibition of Myosin II ATPase. These pharmaceutical compositions also may contain one or more other compounds useful in their active form, as methods of treating a patient suffering from an over-active bladder.

    STRESS COMPENSATED OSCILLATOR CIRCUITRY AND INTEGRATED CIRCUIT USING THE SAME

    公开(公告)号:US20170331429A1

    公开(公告)日:2017-11-16

    申请号:US15227262

    申请日:2016-08-03

    Inventor: Mario MOTZ

    Abstract: A stress compensated oscillator circuitry comprises a sensor arrangement for providing a sensor output signal SSensor, wherein the sensor output signal SSensor is based on an instantaneous stress or strain component a in the semiconductor substrate, a processing arrangement for processing the sensor output signal SSensor and providing a control signal SControl depending on the instantaneous stress or strain component σ in the semiconductor substrate, and an oscillator arrangement for providing an oscillator output signal Sosc having an oscillator frequency fosc based on the control signal SControl, wherein the control signal SControl controls the oscillator output signal Sosc, and wherein the control signal SControl reduces the influence of the instantaneous stress or strain component σ in the semiconductor substrate onto the oscillator output signal Sosc, so that the oscillator circuitry provides a stress compensated oscillator output signal.

    TEMPERATURE COMPENSATION FOR AN OSCILLATOR CRYSTAL

    公开(公告)号:US20170134028A1

    公开(公告)日:2017-05-11

    申请号:US15415307

    申请日:2017-01-25

    Abstract: An electronic device is equipped with an oscillator interface to be coupled to an oscillator crystal of an oscillator element. The electronic device includes an oscillator circuit which is coupled to the oscillator interface and generates an oscillator signal. The electronic device is further provided with a temperature measurement interface to be coupled to a temperature sensor of the oscillator element so as to receive the temperature signal. For accomplishing temperature compensation, the electronic device is provided with a measurement controller coupled to the measurement: interface and configured to measure a first value of the temperature signal at a first point of time and a. second value of the temperature signal at a second point of time. Afrequency drift estimator is provided so as to estimate a frequency drift of the oscillator signal on the basis of the first value of the temperature signal and a second value of the temperature signal. By means of a compensation logic, a frequency compensation signal for the oscillator circuit is generated on the basis of the estimated frequency drift.

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