公开(公告)号：US20180000936A1

公开(公告)日：2018-01-04

申请号：US15708089

申请日：2017-09-18

Applicant: NANO3D BIOSCIENCES INC

Inventor： Glauco R. SOUZA

IPC: A61K41/00 ,  A61L27/18 ,  G01N33/543 ,  A61L27/38 ,  A61N2/00 ,  C12N5/00 ,  G01N33/58 ,  A61L27/50 ,  B03C1/30 ,  B03C1/01 ,  B03C1/034

CPC classification number: A61K41/0052 ,  A61L27/18 ,  A61L27/38 ,  A61L27/50 ,  A61L2400/12 ,  A61L2430/20 ,  A61L2430/30 ,  A61N2/00 ,  B03C1/01 ,  B03C1/034 ,  B03C1/30 ,  B03C2201/26 ,  C12N5/0062 ,  C12N5/0068 ,  C12N2529/00 ,  G01N33/54346 ,  G01N33/587

Abstract: Methods of making and using a magnetic ECM are disclosed. The ECM comprises positively and negatively charged nanoparticles, wherein one of said nanoparticles contains a magnetically responsive element. When the magnetic ECM is seeded with cells, the cells will be magnetized and can be levitated for 3-D cell culture.

公开(公告)号：US20150104844A1

公开(公告)日：2015-04-16

申请号：US14536388

申请日：2014-11-07

Applicant: NANO3D BIOSCIENCES INC.

Inventor： Glauco R. SOUZA

IPC: C12N5/00

CPC classification number: C12N5/0062 ,  B03C1/015 ,  B03C1/30 ,  B03C2201/26 ,  B82Y25/00 ,  C12N5/00 ,  C12N2513/00 ,  C12N2529/00 ,  C12N2531/00 ,  C12N2533/10 ,  C12N2533/32 ,  G01N33/54326 ,  G01N33/544 ,  G01R33/1269 ,  H01F1/0045 ,  H01F1/0063 ,  H01F1/083 ,  H01F1/113 ,  H01F1/445 ,  Y10S977/773 ,  Y10S977/89 ,  Y10S977/904 ,  Y10S977/923

Abstract: A material comprising positively and negatively charged nanoparticles, wherein one of said nanoparticles contained a magnetically responsive element, are combined with a support molecule, which is a long natural or synthetic molecule or polymer to make a magnetic nanoparticle assembly. When the magnetic nanoparticle assembly is combined with cells, it will magnetize those cells. The magnetized cells can then be washed to remove the magnetic nanoparticle assembly and the magnetized cells manipulated in a magnetic field.

Abstract translation: 包含正电荷和带负电荷的纳米颗粒的材料，其中所述纳米颗粒中的一个包含磁响应元件，与作为磁性纳米颗粒组件的长天然或合成分子或聚合物的载体分子组合。 当磁性纳米颗粒组件与细胞结合时，它将磁化这些细胞。 然后可以洗涤磁化的细胞以除去磁性纳米颗粒组件，并且磁化的细胞在磁场中操作。