公开(公告)号：US20160033451A1

公开(公告)日：2016-02-04

申请号：US14872128

申请日：2015-09-30

Applicant: NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY

Inventor： JOHN S. SUEHLE ,  JOHN J. KASIANOWICZ ,  ARVIND BALIJEPALLI ,  JOSEPH W. ROBERTSON ,  JESSICA BENJAMINI

IPC: G01N27/447

CPC classification number: G01N33/48721

Abstract: A single molecule filter includes: a membrane including: a first surface; a second surface; and a membrane aperture disposed in the membrane and traversing the membrane from the first surface to the second surface, the membrane aperture provided to communicate a single molecule across the membrane; and a nanotube disposed on the membrane and including: a first end disposed on the first surface of the membrane; a second end disposed distal to the first surface; and a tubular aperture extending along the nanotube from the first end to the second end, the tubular aperture provided to communicate the single molecule from the second end of the nanotube to the membrane aperture.

Abstract translation: 单分子过滤器包括：膜，包括：第一表面; 第二表面 以及膜孔，其设置在所述膜中并且从所述第一表面穿过所述膜到所述第二表面，所述膜孔设置成使单个分子跨过所述膜连通; 以及布置在膜上的纳米管，包括：设置在膜的第一表面上的第一端; 设置在所述第一表面的远侧的第二端; 以及从所述第一端到所述第二端沿所述纳米管延伸的管状孔，所述管状孔用于将所述单分子从所述纳米管的第二端连通到所述膜孔。

公开(公告)号：US20140064324A1

公开(公告)日：2014-03-06

申请号：US14073126

申请日：2013-11-06

Applicant: National Institute of Standards and Technology

Inventor： JOHN J. KASIANOWICZ ,  Joseph E. Reiner ,  Arvind K. Balijepalli ,  Joseph W. Robertson ,  Daniel L. Burden ,  Lisa Burden

IPC: G01N25/00

CPC classification number: G01N25/00 ,  G01K7/16 ,  G01K2211/00

Abstract: Systems and methods for controlling the temperature of small volumes such as yoctoliter volumes, are described. The systems include one or more plasmonic nanostructures attached at or near a nanopore. Upon excitation of the plasmonic nanostructures, such as for example by exposure to laser light, the nanoparticles are rapidly heated thereby causing a change in the ionic conductance along the nanopore. The temperature change is determined from the ionic conductance. These temperature changes can be used to control rapid thermodynamic changes in molecular analytes as they interact with the nanopore.

Abstract translation: 描述了用于控制小容积（诸如yoctoliter体积）的温度的系统和方法。 该系统包括在纳米孔附近附近的一个或多个等离子体激元纳米结构。 在激发等离子体激元纳米结构时，例如通过暴露于激光，纳米颗粒被快速加热，从而导致沿纳米孔的离子电导的变化。 温度变化由离子电导确定。 这些温度变化可用于控制分子分析物与纳米孔相互作用时的快速热力学变化。