公开(公告)号：US12220239B2

公开(公告)日：2025-02-11

申请号：US18072035

申请日：2022-11-30

Applicant: NORTHWESTERN UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： John A. Rogers ,  Hui Fang ,  Jianing Zhao ,  Enming Song ,  Yoon Kyeung Lee

IPC: A61B5/283 ,  A61B5/03 ,  A61B5/361 ,  A61N1/05 ,  G01N27/414 ,  H01L21/02

Abstract: Provided is a long-term implantable electronic device comprising a first thermally oxidized laver from a first substrate, wherein the first thermally oxidized laver forms a first encapsulation laver; an electronic component supported by the first encapsulation laver, wherein the electronic component and the first encapsulation laver have an exposed surface relative to the first encapsulation laver; a barrier laver that covers the first encapsulation laver and the electronic component exposed surface; a second thermally oxidized layer from a second substrate, wherein the second thermally oxidized layer forms a second encapsulation laver, and the second encapsulation laver is in contact with the barrier layer. Each of the first and second encapsulation layers, the barrier layer, and the electronic component are flexible or bendable, so that the long-term implantable electronic device is configured to conformally contact with a curved biological surface.

公开(公告)号：US12144579B2

公开(公告)日：2024-11-19

申请号：US17043161

申请日：2019-03-29

Applicant: NORTHWESTERN UNIVERSITY

Inventor： John A. Rogers ,  Shuai Xu ,  Yajing Li ,  Philipp Gutruf ,  Surabhi R. Madhvapathy ,  Siddharth Krishnan

IPC: A61B5/00 ,  A61B5/01

Abstract: Provided are wireless electronic devices for thermally interfacing with a biological tissue. The device may have a flexible substrate; a thermal actuator supported by said flexible substrate configured to provide a thermal input to said biological tissue; a temperature sensor supported by said flexible substrate configured to measure a temperature to determine thermal conductivity of said biological tissue; and a wireless electronic system in electronic communication with said thermal actuator and said temperature sensor, wherein said wireless electronic system is configured to provide two-way communication with an external controller. Also provided are related methods of using the electronic devices, including for cosmetic, beauty, or medical applications.

公开(公告)号：US12082916B2

公开(公告)日：2024-09-10

申请号：US17798193

申请日：2021-03-01

Applicant: Vanderbilt University ,  Northwestern University

Inventor： Mark D. Does ,  John A. Rogers

IPC: A61B5/05 ,  A61B5/055

CPC classification number: A61B5/05 ,  A61B5/055 ,  A61B2505/05

Abstract: An implantable bioresorbable radio frequency (RF) coil for high-resolution and high-specificity post-surgical evaluating or monitoring with magnetic resonance imaging (MRI) is disclosed. The coil includes a bioresorbable conductor configured to be resorbed within a patient while the coil is implanted in the patient. In one embodiment, the target application of this coil is the evaluation or monitoring (via MRI) of peripheral nerve regeneration following surgical repair.

公开(公告)号：US11826121B2

公开(公告)日：2023-11-28

申请号：US17372962

申请日：2021-07-12

Applicant: NORTHWESTERN UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： John A. Rogers ,  Seungyong Han ,  Sang Min Won ,  Jeonghyun Kim

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/01 ,  A61B5/026 ,  A61B5/0533 ,  A61B5/08 ,  A61B5/145

CPC classification number: A61B5/0024 ,  A61B5/002 ,  A61B5/02055 ,  A61B5/6804 ,  A61B5/7275 ,  A61B5/746 ,  A61B5/0059 ,  A61B5/015 ,  A61B5/026 ,  A61B5/0533 ,  A61B5/0816 ,  A61B5/14542 ,  A61B5/4266 ,  A61B5/447 ,  A61B5/4818 ,  A61B2503/40 ,  A61B2560/0214 ,  A61B2562/0247

Abstract: Provided herein are medical devices comprising a plurality of biologically interactive devices configured for interacting with a large area biological surface. The biologically interactive devices each may comprise a sensor for measuring a physiological parameter. A wireless controller is configured to wirelessly operate the plurality of biologically interactive devices. A wireless transmitter is configured for wirelessly communicating an output from said plurality of biologically interactive devices to a remote receiver. The medical devices are particularly suited for measuring one or both of pressure and temperature, with compatibility for incorporating additional sensors of interest.

公开(公告)号：US20230301595A1

公开(公告)日：2023-09-28

申请号：US18021418

申请日：2021-08-18

Applicant: NORTHWESTERN UNIVERSITY ,  THE GEORGE WASHINGTON UNIVERSITY

Inventor： John A. Rogers ,  Roozbeh Ghaffari ,  Igor Efimov ,  Mengdi Han

IPC: A61B5/00 ,  A61B5/367 ,  A61B5/287 ,  A61B5/263 ,  A61B5/0205 ,  A61B18/14

CPC classification number: A61B5/6853 ,  A61B5/367 ,  A61B5/287 ,  A61B5/263 ,  A61B5/02055 ,  A61B5/6885 ,  A61B5/4839 ,  A61B18/1492 ,  A61B2562/125 ,  A61B2562/164 ,  A61B2562/066

Abstract: An electronic system for multimodal diagnostic measurements and therapeutic interventions includes a plurality of element network layers vertically stacked one with another on a flexible substrate, each element network layer being bi-axially stretchable and comprising a plurality of elements configured in an addressable, interconnected array formed in a multilayered structure and operably performing a distinct function. The electronic system is a multimodal, multiplexed soft electronic system in a multilayered configuration that supports capabilities ranging from high-density spatiotemporal mapping of temperature, pressure and electrophysiological parameters, to options in programmable high-density actuation of thermal inputs and/or electrical stimulation, drug elution, radio frequency ablation, and/or irreversible electroporation ablation.

公开(公告)号：US11517238B2

公开(公告)日：2022-12-06

申请号：US16162613

申请日：2018-10-17

Applicant: Northwestern University ,  The Board of Trustees of the University of Illinois

Inventor： John A. Rogers ,  Hui Fang ,  Jianing Zhao ,  Enming Song ,  Yoon Kyeung Lee

IPC: A61B5/283 ,  H01L21/02 ,  A61N1/05 ,  A61B5/03 ,  A61B5/361 ,  G01N27/414

Abstract: Provided are methods of making a long-term implantable electronic device, and related implantable devices, including by providing a substrate having a first encapsulation layer that covers at least a portion of the substrate, the first encapsulation layer having a receiving surface; providing one or more electronic devices on the first encapsulation layer receiving surface; and removing at least a portion of the substrate from the first encapsulation layer; thereby making the long-term implantable electronic device. Further desirable properties, including device lifetime increases during use in environments that are challenging for sensitive electronic device components, are achieved through the use of additional layers such as longevity-extending layers and/or ion-barrier layers in combination with an encapsulation layer.

公开(公告)号：US09825229B2

公开(公告)日：2017-11-21

申请号：US14772312

申请日：2014-04-03

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  NORTHWESTERN UNIVERSITY ,  UNIVERSITY OF MIAMI

Inventor： John A. Rogers ,  William L. Wilson ,  Sung Hun Jin ,  Simon N. Dunham ,  Xu Xie ,  Ahmad Islam ,  Frank Du ,  Yonggang Huang ,  Jizhou Song

IPC: H01L51/00 ,  H01L21/02 ,  C01B31/02

CPC classification number: H01L51/0048 ,  B82Y30/00 ,  C01B31/026 ,  C01B32/17 ,  C01B2202/22 ,  C01B2202/34 ,  G01N21/62 ,  H01L21/02606 ,  H01L51/0004 ,  H01L51/0025 ,  H01M4/1393

Abstract: The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein the precursor layer comprises a mixture of first carbon nanotubes and second carbon nanotubes; selectively heating the first carbon nanotubes; and separating the first carbon nanotubes from the second carbon nanotubes, thereby generating a purified layer of carbon nanotubes. Devices benefiting from enhanced electrical properties enabled by the purified layer of carbon nanotubes are also described.

公开(公告)号：US20250114517A1

公开(公告)日：2025-04-10

申请号：US18567428

申请日：2022-06-10

Applicant: NORTHWESTERN UNIVERSITY ,  WASHINGTON UNIVERSITY

Inventor： John A. Rogers ,  Abraham Vazquez-Guardado ,  Joanna L. Ciatti ,  Yamin Zhang ,  Jin Wang ,  Robert W. Gereau

IPC: A61M5/142 ,  A61M5/14 ,  A61M5/158 ,  A61M5/172 ,  A61M5/20 ,  A61M5/31 ,  A61M39/22 ,  A61M39/24 ,  G16H15/00

Abstract: An implantable device for monitoring a physiological status and administering drugs therefor includes at least one drug reservoir for containing at least one drug solution; a delivering member coupled to the at least one drug reservoir for operably delivering the at least one drug solution from the at least one drug reservoir to the living subject; a sensor member for measuring physiological parameters of a living subject so as to monitor a physiological status of the living subject; a wireless communication system for wireless data transmission; a power management system for wireless power harvesting; and a controller coupled to the power management system, the wireless communication system, the sensor member and the delivering member for wireless data transmission and power harvesting; obtaining the physiological status of the living subject, and controlling operations of the delivering member based on the physiological status of the living subject.

公开(公告)号：US20250072820A1

公开(公告)日：2025-03-06

申请号：US18725885

申请日：2023-01-09

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Lorenzo Gallon ,  John A. Rogers ,  Surabhi Rao Madhvapathy ,  Zheng Jenny Zhang

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/0265 ,  A61B5/20

Abstract: The invention provides an implantable device and method of monitoring wirelessly and continuously thermal conductivity and blood flow on the surface of a target region of a subject. The implantable device comprises a probe operably attached to the target region; and an electronic module coupled with the probe for wireless, real-time, and continuous measurements of physiological information of the target region.

公开(公告)号：US20250032311A1

公开(公告)日：2025-01-30

申请号：US18716989

申请日：2022-12-09

Applicant: NORTHWESTERN UNIVERSITY ,  WASHINGTON UNIVERSITY

Inventor： John A. Rogers ,  Jonathan T. Reeder ,  Matthew MacEwan ,  Wilson Z. Ray

IPC: A61F7/12 ,  A61F7/00

Abstract: A device for reversibly blocking activities of a target region of a subject includes a microfluidic system configured to route a fluid around the target region to change a local temperature of the target region; and an electronic system coupled with the microfluidic system for providing a real-time feedback.